FLIP Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

FLIP (Flice-like Inhibitory Protein), also known as I-FLICE, CASPER, and FLAME-1, is an apoptosis inhibitory protein with architecture similar to that of Caspases-8 and -10. Both of the FLIP isoforms, Long (L) and Short (S), contain two death effector domains (DED). FLIP(L) has a C-terminal Caspase-like protease domain which lacks both a catalytic active site and residues that form a substrate-binding pocket. FLIP(S) and FLIP(L) interact with the adaptor molecule FADD, and potently inhibit apoptosis initiated by Fas Ligand/TNF signaling pathways.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Porcine.

We have publications tested in 4 applications: Flow Cytometry, ICC, IHC, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using AF821	Applications	Species
J Huangfu, C Hao, Z Wei, IM Wormstone, H Yan, X Fan Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells Cell Death & Disease, 2021-04-09;12(4):386. 2021-04-09 [PMID: 33837174] (Western Blot, Mouse)	Western Blot	Mouse
R Bulvik, M Biton, N Berkman, R Breuer, SB Wallach-Da Forefront: MiR-34a-Knockout Mice with Wild Type Hematopoietic Cells, Retain Persistent Fibrosis Following Lung Injury Int J Mol Sci, 2020-03-23;21(6):. 2020-03-23 [PMID: 32210149] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
WR English, H Ireland-Ze, AH Baker, TD Littlewood, MR Bennett, G Murphy Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells PLoS ONE, 2018-04-04;13(4):e0195116. 2018-04-04 [PMID: 29617412] (Western Blot, Human)	Western Blot	Human
M Ejarque, V Ceperuelo-, C Serena, G Pachón, Y Núñez-Álva, M Terrón-Pui, E Calvo, C Núñez-Roa, W Oliva-Oliv, FJ Tinahones, MA Peinado, J Vendrell, S Fernández- Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis Cell Death Dis, 2017-05-18;8(5):e2802. 5/18/2017 [PMID: 28518147]
French R, Hayward O, Jones S, Yang W, Clarkson R Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL. Mol Cancer, 2015-12-15;14(0):209. 12/15/2015 [PMID: 26667821]
Angela M. Valverde, Soledad Miranda, Marta García-Ramírez, Águeda González-Rodriguez, Cristina Hernández, Rafael Simó Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy Mol. Vis 1/7/2013 [PMID: 23335850]
Jantschitsch C, Majewski S, Maeda A, Schwarz T, Schwarz A Infrared radiation confers resistance to UV-induced apoptosis via reduction of DNA damage and upregulation of antiapoptotic proteins. J. Invest. Dermatol., 2008-11-27;129(5):1271-9. 2008-11-27 [PMID: 19037232] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Stefanescu R, Bassett D, Modarresi R, Santiago F, Fakruddin M, Laurence J Synergistic interactions between interferon-gamma and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma-associated apoptosis. Blood, 2008-03-13;112(2):340-9. 2008-03-13 [PMID: 18339897] (Western Blot, Human)	Western Blot	Human
Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets. Diabetes, 2006-10-01;55(10):2713-22. 2006-10-01 [PMID: 17003335] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Bai L, Maedler K, Donath M, Tuch BE Expression of Fas but not Fas ligand on fetal pig beta cells. Xenotransplantation, 2004-09-01;11(5):426-35. 2004-09-01 [PMID: 15303979] (ICC, Porcine)	ICC	Porcine
Sade H, Krishna S, Sarin A The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J. Biol. Chem., 2003-10-28;279(4):2937-44. 2003-10-28 [PMID: 14583609] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
Show All 11 Publications. Collapse Publications.

Array AF821

• FLIP Antibodies
• FLIP ELISA Kits
• FLIP Lysates
• FLIP Proteins
• FLIP Proteins and Enzyme