TERF2IP Antibody (78B356.1)

Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares 3 conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 2 of 2.

Publications using NB100-56526	Applications	Species
Nijjar Tarlochan, Bassett Ekaterina, Garbe James et al. Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells. Oncogene. 2005-05-05 [PMID: 15735711] (Human)		Human
Kim SH, Beausejour C, Davalos AR et al. TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem. 2004-10-15 [PMID: 15292264]

Array NB100-56526

• TERF2IP Antibodies
• TERF2IP ELISA Kits
• TERF2IP Lysate
• TERF2IP Proteins