TDP-43/TARDBP Antibody - BSA Free

TARDBP (tar-DNA binding protein of 43) is a nucleic acids binding protein that regulates the process of transcription and splicing. Localized mainly in the nucleus, TARDBP is ubiquitously expressed with higher expression levels in pancreas, placenta, lung, genital tract and spleen, and has been suggested to implicate in microRNA biogenesis, cellular apoptosis as well as proliferation. TARDBP controls CFTR splicing and promotes CFTR exon 9 skipping by associating with UG repeated motifs in polymorphic region near 3'-splice site of this exon leading to aberrant splicing linked to pathological features typical of cystic fibrosis. TARDBP can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Moreover, it stabilizes the low molecular weight neurofilament mRNA through a direct interaction with the 3' UTR. TARDBP was originally identified as a major protein component of the ubiquitin immuno-positive inclusions which are the pathologic substrate of common forms of ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), and later, it was found that TARDBP gene mutations are inherited in an autosomal dominant manner in familial/sporadic ALS. TARDBP has also been involved in other neurodegenerative such as Alzheimer's and Parkinson's disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Zebrafish.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using NB110-55376	Applications	Species
Tejwani L, Jung Y, Kokubu H et al. Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration Journal of Clinical Investigation 2023-08-15 [PMID: 37384409]
Kobayashi M, Chandrasekhar A, Cheng C et al. Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22. Dis Model Mech. 2017-03-01 [PMID: 28250049]
Goossens J, Vanmechelen E, Trojanowski JQ et al. TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies Acta Neuropathol Commun 2015-04-09 [PMID: 25853864] Details: This publication is a systematic review of existing antibodies for TDP-43/TARDBP.
Li Q, Yokoshi M, Okada H, Kawahara Y. The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity Nat Commun. 2015-01-29 [PMID: 25630387]
Fang YS, Tsai KJ, Chang YJ et al. Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients. Nat Commun. 2014-09-13 [PMID: 25215604]
Udan-Johns M, Bengoechea R, Bell S et al. Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones. Hum Mol Genet. 2013-09-04 [PMID: 23962724] (WB, Human)	WB	Human
Schmid B, Hruscha A, Hogl S et al. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth Proc Natl Acad Sci U S A 2013-03-26 [PMID: 23457265] (WB, Zebrafish)	WB	Zebrafish
Kawahara Y, Mieda-Sato A. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proc Natl Acad Sci U S A;109(9):3347-52. 2012-02-28 [PMID: 22323604]
Mitne-Neto M, Machado-Costa M, Marchetto MCN et al. Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem-cells of ALS8 patients. Hum Mol Genet;20(18):3642-52. 2011-09-15 [PMID: 21685205] (ICC/IF, Human)	ICC/IF	Human
Shiina Y, Arima K, Tabunoki H et al. TDP-43 dimerizes in human cells in culture. Cell Mol Neurobiol 2010-05-01 [PMID: 20043239] (WB, Human)	WB	Human
Wegorzewska I, Bell S, Cairns NJ et al. TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A;106(44):18809-14. 2009-11-03 [PMID: 19833869] (IF/IHC, Human)	IF/IHC	Human
Geser F et al. Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis. Arch Neurol. 65(5):636-41. 2008-05-01 [PMID: 18474740] (IF/IHC, Human)	IF/IHC	Human
Tejwani L, Kokubu H, Lee PJ et al. Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration bioRxiv 2020-01-01 (WB)	WB
Yasuhara T, Xing Y, Bauer N et al. Condensates induced by transcription inhibition localize active chromatin to nucleoli Molecular Cell 2022-06-01 [PMID: 35662392]
Show All 14 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	WB	Mouse	01/09/2015	View Summary Application Western Blot Sample Tested mouse brain lysates Species Mouse Lot A-3

Array NB110-55376

• TDP-43/TARDBP Antibodies
• TDP-43/TARDBP ELISA Kits
• TDP-43/TARDBP Lysate
• TDP-43/TARDBP Proteins
• TDP-43/TARDBP Proteins and Enzyme