TBC1D1 Antibody

Images

 
Immunochemical staining of TBC1D1 in human gallbladder formalin-fixed paraffin embedded sections with NBP3-21442 at 1:100 dilution
Immunochemical staining of TBC1D1 in human kidney formalin-fixed paraffin embedded sections with NBP3-21442 at 1:100 dilution
Immunohistochemistry-Paraffin: TBC1D1 Antibody [NBP3-21442] - Immunochemical staining of human TBC1D1 in human gallbladder with NBP3-21442 at 1:100 dilution, formalin-fixed paraffin embedded sections.
Immunohistochemistry-Paraffin: TBC1D1 Antibody [NBP3-21442] - Immunochemical staining of human TBC1D1 in human kidney with NBP3-21442 at 1:100 dilution, formalin-fixed paraffin embedded sections.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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TBC1D1 Antibody Summary

Description
This antibody can be stored at 2-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C.
Immunogen
Produced in rabbits immunized with E. coli-derived Human TBC1D1 fragment
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TBC1D1
Purity
Antigen and protein A Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1:50-1:200

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.0
Preservative
0.03% Proclin 300
Purity
Antigen and protein A Affinity-purified

Alternate Names for TBC1D1 Antibody

  • KIAA1108TBC
  • TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
  • TBC1 domain family member 1
  • TBC1

Background

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Research Areas for TBC1D1 Antibody (NBP3-21442)

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Blogs on TBC1D1.

Muscle-specific UBE2O ablation requires activated AMPK alpha 2 to protect against metabolic syndrome
By Jamshed Arslan, Pharm. D., PhD. Generating energy (ATP) from nutrients is a recipe for life. One of the sensors of cellular energy levels is the serine/threonine kinase AMPK. This enzyme facilitates lipid oxidati...  Read full blog post.

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Bioinformatics

Gene Symbol TBC1D1