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SUMO1 Antibody (SUMO1/1188) [DyLight 550]

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Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, CyTOF-ready, ICC/IF
Clone
SUMO1/1188
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 550

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-47697AF350
Alexa Fluor 405
NBP2-47697AF405
Alexa Fluor 488
NBP2-47697AF488
Alexa Fluor 532
NBP2-47697AF532
Alexa Fluor 594
NBP2-47697AF594
Alexa Fluor 647
NBP2-47697AF647
Alexa Fluor 700
NBP2-47697AF700
Alexa Fluor 750
NBP2-47697AF750
Allophycocyanin
NBP2-47697APC
Biotin
NBP2-47697B
DyLight 350
NBP2-47697UV
DyLight 405
NBP2-47697V
DyLight 488
NBP2-47697G
DyLight 594
NBP2-47697DL594
DyLight 650
NBP2-47697C
DyLight 680
NBP2-47697FR
DyLight 755
NBP2-47697IR
FITC
NBP2-47697F
HRP
NBP2-47697H
Janelia Fluor 549
NBP2-47697JF549
Janelia Fluor 646
NBP2-47697JF646
PE
NBP2-47697PE
PerCP
NBP2-47697PCP
Unconjugated
NBP2-44460-0.1mg
mFluor Violet 450 SE
NBP2-47697MFV450
mFluor Violet 500 SE
NBP2-47697MFV500
mFluor Violet 610 SE
NBP2-47697MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-44460-0.1mg
Azide and BSA Free
NBP2-47697-0.1mg
IHC-Prediluted
NBP2-48449
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SUMO1 Antibody (SUMO1/1188) [DyLight 550] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Recombinant human SUMO1 protein (Uniprot: P63165)
Localization
Predominantly nuclear with some cytoplasmic
Specificity
This monoclonal antibody is specific to SUMO-1 and shows no cross-reaction with either SUMO-2 or SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1 protein localizes to the nuclear membrane.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SUMO1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Predicted to show a broad species reactivity.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for SUMO1 Antibody (SUMO1/1188) [DyLight 550]

  • DAP1
  • GAP modifying protein 1
  • GAP-modifying protein 1
  • GMP1SMT3CSMT3H3OFC10UBL1PIC1
  • PIC1
  • SENP2
  • Sentrin
  • small ubiquitin-related modifier 1
  • SMT3 homolog 3
  • SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
  • SMT3 suppressor of mif two 3 homolog 1 (yeast)
  • SMT3
  • SMT3C
  • SMT3H3
  • SUMO1
  • SUMO-1
  • Ubiquitin-homology domain protein PIC1
  • ubiquitin-like 1 (sentrin)
  • Ubiquitin-like protein SMT3C
  • Ubiquitin-like protein UBL1
  • UBL1

Background

Sumo 1 is a ubiquitin-like protein which binds to a wide range of target proteins. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. SUMO 1 is also known to form a complex with RanGAP1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SUMO1 Antibody
(SUMO1/1188) [DyLight ...
NBP2-47697R
SUMO1 Antibody (SUMO1/1188) [DyLight 550]
Species: Hu, Rt
Applications: WB, Flow, ICC/IF, IHC, CyTOF-ready, ICC/IF

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Bioinformatics

Gene Symbol SUMO1