SENP6 Antibody (4B7)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 6 of 6.

Publications using H00026054-M01	Applications	Species
Colnaghi L, Conz A, Russo L et al. Neuronal Localization of SENP Proteins with Super Resolution Microscopy Brain Sci 2020-10-25 [PMID: 33113832]
Lin X, Sun R, Zhang F et al. The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/sentrin Specific Peptidase 6 to Facilitate Latency Establishment. J Virol 2017-06-14 [PMID: 28615201]
Tosti E, Katakowski JA, Schaetzlein S. Exploiting evolutionarily conserved genetic interactions with budding and fission yeast MutS to identify orthologous relationships in MMR-deficient cancer cells. Genome Medicine. 2014-09-17 [PMID: 25302077]
Liu X, Chen W, Wang Q et al. Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6. PLoS Pathog. 2013-06-27 [PMID: 23825957]
Dou H, Huang C, Singh M et al. Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex. Mol Cell. 2010-08-13 [PMID: 20705237]
Han Y, Huang C, Sun X et al. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem 285(17):12906-15. 2010-04-23 [PMID: 20181954]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	Flow	Human	04/25/2014	View Summary Application Flow Cytometry Sample Tested Human Cell lines Species Human Lot 1182-4b7

Array H00026054-M01

• SENP6 Antibodies
• SENP6 Lysate