SENP6 Products

Description

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM]

Bioinformatics

Entrez	215351 Mouse 26054 Human 300860 Rat
Uniprot	NP_001093879.1 Human NP_056386 Human Q9GZR1 Human
Product By Gene ID	26054
Alternate Names	EC 3.4.22.- KIAA0797FLJ11887 Sentrin/SUMO-specific protease SENP6 sentrin-specific protease 6 SSP1KIAA0389 SUMO1/sentrin specific peptidase 6,2810017C20Rik SUMO1/sentrin specific protease 6 SUMO-1-specific protease 1 SUSP1FLJ11355