STAG2 Antibody

SA2 is a component of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which, sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. The subunit interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1L1 or SMC1L2) and SMC3, which are attached via their hinge domain, and RAD21 links them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 7 of 7.

Publications using NB100-300	Applications	Species
Zhang N, Panigrahi AK, Mao Q et al. Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion. J Biol Chem. 2011-12-02 [PMID: 21987589] (WB, Human)	WB	Human
Zhu Y, Wu Z, Cardoso MC et al. Processing of lagging-strand intermediates in vitro by herpes simplex virus type 1 DNA polymerase. J Virol 2010-08-01 [PMID: 20444887]
Kong X, Mohanty SK, Stephens J et al. Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells. Nucleic Acids Res 2009-05-01 [PMID: 19357094]
Kong X, Ball AR Jr, Sonoda E et al. Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells. Mol Biol Cell 2009-03-01 [PMID: 19116315]
Zhang N, Kuznetsov SG, Sharan SK et al. A hcuff model for the cohesin complex. J Cell Biol;183(6):1019-1031. 2008-01-01 [PMID: 19075111]
Yalcin S, Zhang X, Luciano JP et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem 2008-09-01 [PMID: 18424439]
Dai J, Sullivan BA, Higgins JM et al. Regulation of mitotic chromosome cohesion by Haspin and Aurora B. Dev Cell 2006-11-01 [PMID: 17084365]

Array NB100-300

• STAG2 Antibodies
• STAG2 Protein