Name: TMEPAI Antibody (2A12)
Brand: Novus Biologicals
SKU: H00056937-M01
Price: 519 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, RtSpecies Glossary
Applications	WB, ELISA, ICC/IF, IHC
Clone	2A12
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Immunogen	TMEPAI (AAH15918, 181 a.a. ~ 280 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. NRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL
Localization	Cell Membrane
Specificity	TMEPAI - transmembrane, prostate androgen induced RNA
Isotype	IgG2a Kappa
Clonality	Monoclonal
Host	Mouse
Gene	PMEPA1
Purity	IgG purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer	In 1x PBS, pH 7.4
Preservative	No Preservative
Purity	IgG purified

Publications using H00056937-M01	Applications	Species
Sharad S, Sztupinszki Z, Chen Y et al. Analysis of PMEPA1 Isoforms (a and b) as Selective Inhibitors of Androgen and TGF-? Signaling Reveals Distinct Biological and Prognostic Features in Prostate Cancer. Cancers (Basel). 2019-12-12 [PMID: 31842254]
Singha P, Pandeswara S, Geng H et al. Increased Smad3 and reduced Smad2 levels mediate the functional switch of TGF-? from growth suppressor to growth and metastasis promoter through TMEPAI/PMEPA1 in triple negative breast cancer. Genes Cancer. 2019-06-27 [PMID: 31798766]
Oh S, Shin S, Song H et al. Relationship between ETS Transcription Factor ETV1 and TGF-?-regulated SMAD Proteins in Prostate Cancer. Sci Rep. 2019-06-03 [PMID: 31160676]
Kumar P, Sharad S, Petrovics G et al. Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1. Oncotarget 2016-04-19 [PMID: 26988912] (WB)	WB
Li H, Mohamed AA, Sharad S et al. Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN. Oncotarget 2015-06-20 [PMID: 25883222] (WB)	WB
Singha PK, Pandeswara S, Geng H et al. TGF-b induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer. Genes Cancer. 2014-09-01 [PMID: 25352949]
O Hainmhire E, Quartuccio SM, Cheng W et al. Mutation or Loss of p53 Differentially Modifies TGFb Action in Ovarian Cancer PLoS One. 2014-02-20 [PMID: 24586866]
Hu Y, He K, Wang D et al. TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways. Carcinogenesis. 2013-04-24 [PMID: 23615405]
Costea DE, Hills A, Osman AH et al. Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma. Cancer Res. 2013-04-18 [PMID: 23598279]
Singha PK, Yeh IT, Venkatachalam MA et al. Transforming Growth Factor-{beta} (TGF-{beta})-Inducible Gene TMEPAI Converts TGF-{beta} from a Tumor Suppressor to a Tumor Promoter in Breast Cancer. Cancer Res. 2010-07-07 [PMID: 20610632]
Watanabe Y, Itoh S, Goto T et al. TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol Cell 37(1):123-34. 2010-01-15 [PMID: 20129061]
Li H, Xu LL, Masuda K et al. A feedback loop between the rogen receptor a NEDD4 binding protein, PMEPA1 in prostate cancer cells. J Biol Chem;283(43):28988-95. 2008-10-24 [PMID: 18703514]
Hirokawa YS, Takagi A, Uchida K et al. High level expression of STAG1/PMEPA1 in an rogen-independent prostate cancer PC3 subclone. Cell Mol Biol Lett. 2007-02-17 [PMID: 17318295]
Show All 13 Publications. Collapse Publications.

TMEPAI Antibody (2A12)

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Bioinformatics

Gene Symbol	PMEPA1
Entrez	56937(Human)
OMIM	606564(Human)
Uniprot	AAH15918(Human)