SMC3 Antibody

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosome movement.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, C. elegans.

We have publications tested in 2 applications: Chemotaxis, IF/IHC.

Showing Publications 1 - 9 of 9.

Publications using NB100-207	Applications	Species
Tao, H, Lambert, J P Et al. IRX3/5 regulate mitotic chromatid segregation and limb bud shape. Development 2020-10-05 [PMID: 32907847] (Chemotaxis, Human)	Chemotaxis	Human
Bowman R, Balukof N, Ford T, Smolikove S. A Novel Role for a-importins and Akirin in Establishment of Meiotic Sister Chromatid Cohesion in Caenorhabditis elegans Genetics 2018-12-18 [PMID: 30563860] (IF/IHC, C. elegans)	IF/IHC	C. elegans
Deardorff MA, Bando M, Nakato R et al. HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature 2012-09-01 [PMID: 22885700]
Shiomi Y, Hayashi A, Ishii T et al. Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation. Mol Cell Biol. 2012-06-01 [PMID: 22493068]
Leman AR, Noguchi C, Lee CY et al. Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion. J Cell Sci 2010-03-01 [PMID: 20124417]
Terret ME, Sherwood R, Rahman S et al. Cohesin acetylation speeds the replication fork. Nature 2009-11-01 [PMID: 19907496]
Adelfalk C, Janschek J, Revenkova E et al. Cohesin SMC1beta protects telomeres in meiocytes. J Cell Biol 2009-10-01 [PMID: 19841137]
Rankin S, Ayad NG, Kirschner MW et al. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell 2005-04-01 [PMID: 15837422]
Revenkova E, Eijpe M, Heyting C et al. Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination. Nat Cell Biol 2004-06-01 [PMID: 15146193]

Array NB100-207

• SMC3 Antibodies
• SMC3 Lysate
• SMC3 Proteins