Orthogonal Strategies: Immunohistochemistry-Paraffin: SRGN Antibody [NBP1-80886] - Analysis in human bone marrow and skeletal muscle tissues using NBP1-80886 antibody. Corresponding SRGN RNA-seq data are ...read more
Orthogonal Strategies: Western Blot: SRGN Antibody [NBP1-80886] - Analysis in human cell lines A-549 and Caco-2. Corresponding RNA-seq data are presented for the same cell lines. Loading control: Anti-GAPDH.
Immunohistochemistry-Paraffin: SRGN Antibody [NBP1-80886] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
Immunohistochemistry-Paraffin: SRGN Antibody [NBP1-80886] - Staining of human tonsil shows moderate cytoplasmic positivity in germinal center cells.
Immunohistochemistry-Paraffin: SRGN Antibody [NBP1-80886] - Staining of human gastrointestinal shows moderate cytoplasmic positivity in lymphoid cells.
Immunohistochemistry-Paraffin: SRGN Antibody [NBP1-80886] - Staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells.
This antibody was developed against Recombinant Protein corresponding to amino acids: MQKLLKCSRLVLALALILVLESSVQGYPTRRARYQWVRCNPDSNSANCLEEKGPMFELLPGESNKIPRLRTDLFPKTRIQDLNRIFPLSEDYSGSGFGSGSGSGSGSGSGFLTEMEQDYQLVDE
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SRGN
Purity
Immunogen affinity purified
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for SRGN Antibody
FLJ12930
Hematopoetic proteoglycan core protein
MGC9289
P.PG
Platelet proteoglycan core protein
platelet proteoglycan protein core
PPG
PRG1p.PG
PRGhematopoetic proteoglycan core peptide
proteoglycan 1, secretory granule
proteoglycan protein core for mast cell secretory granule
secretory granule proteoglycan 1
secretory granule proteoglycan core peptide
Secretory granule proteoglycan core protein
serglycin proteoglycan
Serglycin
SRGN
Background
SRGN encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. [provided by RefSeq]
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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