We found the difference of Species info between Novus and Abnova pages regarding the same antibody H00001491-M01. Because our customer would like use this antibody with samples from mouse and rat, we wonder if this antibody is suitable?

Name: Cystathionase Antibody (4E1-1B7)
Brand: Novus Biologicals
SKU: H00001491-M01
Price: 519 USD

Question

We found the difference of Species info between Novus and Abnova pages regarding the same antibody H00001491-M01.  Because our customer would like use this antibody with samples from mouse and rat, we wonder if this antibody is suitable?

Accepted Answer

Actually, H00001491-M01 has been successfully tested with Mouse and Rat samples by our customers as is evident from published papers. Following research papers may be referred for additional details: Bucci M, Papapetropoulos A, Vellecco V et al. cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation PLoS One 2012 [PMID: 23285278] (IHC, ICC/IF, WB, Mouse) Wallace JL, Dicay M, McKnight W et al. Hydrogen sulfide enhances ulcer healing in rats. FASEB J;21(14):4070-6. 2007 Dec. [PMID: 17634391] (rat)

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, Rt, Po, GpSpecies Glossary
Applications	WB, ELISA, ICC/IF, IHC
Clone	4E1-1B7
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Description	Quality control test: Antibody Reactive Against Recombinant Protein.
Immunogen	CTH (AAH15807, 1 a.a. ~ 405 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGRSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
Localization	Cytoplasmic
Specificity	CTH - cystathionase (cystathionine gamma-lyase)
Isotype	IgG1 Kappa
Clonality	Monoclonal
Host	Mouse
Gene	CTH
Purity	IgG purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer	In 1x PBS, pH 7.4
Preservative	No Preservative
Purity	IgG purified

Publications using H00001491-M01	Applications	Species
R Bok, DD Guerra, RA Lorca, SA Wennersten, PS Harris, AK Rauniyar, SP Stabler, KN MacLean, JR Roede, LD Brown, KJ Hurt Cystathionine &gamma-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis Redox Biology, 2020-12-08;40(0):101827. 2020-12-08 [PMID: 33485059]
Jin Z, Zhang Q, Wondimu E et al. H2S stimulated bioenergetics in chicken erythrocytes and the underlying mechanism Am. J. Physiol. Regul. Integr. Comp. Physiol. 2020-05-20 [PMID: 32432916]
Novera W, Lee ZW, Nin DS et al. Cysteine deprivation targets ovarian clear cell carcinoma via oxidative stress and iron-sulfur cluster biogenesis deficit Antioxid. Redox Signal. 2020-04-25 [PMID: 32336105]
Noriyuki A, Tatsuro M, Masashi M et al. Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria. Int J Mol Sci. 2020-01-27 [PMID: 32012740]
Xu J, Gao D, Peng L et al. The gasotransmitter hydrogen sulfide inhibits transepithelial anion secretion of pregnant mouse endometrial epithelium. Nitric Oxide. 2019-06-05 [PMID: 31175932]
Gambari L, Amore E, Raggio R et al. Hydrogen sulfide-releasing silk fibroin scaffold for bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2019-04-13 [PMID: 31147018]
Yuan YQ, Wang YL, Yuan BS et al. Impaired CBS-H2S signaling axis contributes to MPTP-induced neurodegeneration in a mouse model of Parkinson's disease. Brain Behav Immun 2017-07-31 [PMID: 28774789]
Mitidieri E, Tramontano T, Gurgone D et al. Beta 3 adrenergic receptor activation relaxes human corpus cavernosum and penile artery through a hydrogen sulfide/cGMP-dependent mechanism. Pharmacol. Res. 2017-07-29 [PMID: 28760490]
Nubbaum BL, McCook O, Hartmann C et al. Left ventricular function during porcine-resuscitated septic shock with pre-existing atherosclerosis. Intensive Care Med Exp 2016-06-01 [PMID: 27271248]
Li JJ, Li Q, Du HP et al. Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter. Int. 2015-06-03 [PMID: 26047341]
Xu Y, Du HP, Li J et al. Statins upregulate cystathionine gamma-lyase transcription and H2S generation via activating Akt signaling in macrophage. Pharmacol Res. 2014-09-01 [PMID: 24951966] (Mouse)		Mouse
Ida T, Sawa T, Ihara H et al. Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. Proc Natl Acad Sci U S A. 2014-04-14 [PMID: 24733942]
Badiei A, Rivers-Auty J, Ang AD, Bhatia M. Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Appl Microbiol Biotechnol. 2013-07-10 [PMID: 23838794]
Mani S, Li H, Untereiner A et al. Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis. Circulation. 2013-05-23 [PMID: 23704252]
Cindrova-Davies T, Herrera EA, Niu Y et al. Reduced Cystathionine gamma-Lyase and Increased MicroRNA-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies: Hydrogen Sulfide as a Placental Vasodilator. Am J Pathol 2013-02-11 [PMID: 23410520] (WB, Human)	WB	Human
Bucci M, Papapetropoulos A, Vellecco V et al. cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation. PLoS One. 2012-12-28 [PMID: 23285278] (WB, IF/IHC, ICC/IF, Mouse)	WB, IF/IHC, ICC/IF	Mouse
Yang G, Zhao K, Ju Y et al. Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2. Antioxid Redox Signal. 2013-02-07 [PMID: 23176571]
Fu M, Zhang W, Yang G, Wang R. Is cystathionine gamma-lyase protein expressed in the heart? Biochem Biophys Res Commun. 2012-11-30 [PMID: 23122812] (WB)	WB
Wu B, Teng H, Yang G et al. Hydrogen Sulfide Inhibits the Translational Expression of Hypoxia-inducible Factor-1alpha. Br J Pharmacol. 2012-07-18 [PMID: 22831549]
Dufton N, Natividad J, Verdu EF, Wallace JL. Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe. Sci Rep. 2012-07-09 [PMID: 22787557]
Holwerda KM, Bos EM, Rajakumar A et al. Hydrogen sulfide producing enzymes in pregnancy and preeclampsia. Placenta. 2012-03-03 [PMID: 22391326]
Yang G, Li H, Tang G et al. Increased neointimal formation in cystathionine gamma-lyase deficient mice: Role of hydrogen sulfide in alpha5b1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells. J Mol Cell Cardiol. 2011-12-19 [PMID: 22200376]
Li X, Mao XB, Hei RY et al. Protective Role of Hydrogen Sulfide against Noise-Induced Cochlear Damage: A Chronic Intracochlear Infusion Model. PLoS One. 2011-10-26 [PMID: 22046339]
Yang G, Pei Y, Cao Q, Wang R. MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells. J Cell Physiol. 2011-10-27 [PMID: 22034194]
Yang G, Pei Y, Teng H et al. Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells. J Biol Chem. 2011-06-09 [PMID: 21659522]
Kasparek MS, Linden DR, Farrugia G, Sarr MG. Hydrogen sulfide modulates contractile function in rat jejunum. J Surg Res. 2012-06-15 [PMID: 21571312] (ICC/IF, Rat)	ICC/IF	Rat
Martin GR, McKnight GW, Dicay MS et al. Hydrogen sulphide synthesis in the rat mouse gastrointestinal tract. Dig Liver Dis. 2009-06-29 [PMID: 19570733]
Wallace JL, Vong L, McKnight W et al. Endogenous and Exogenous Hydrogen Sulfide Promotes Resolution of Colitis in Rats. Gastroenterology. 2009-04-15 [PMID: 19375422]
Feng X, Chen Y, Zhao J et al. Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator. Biochem Biophys Res Commun. 2009-01-21 [PMID: 19166813]
Fua Z, Liua X, Geng B et al. Hydrogen sulfide protects rat lung from ischemia-reperfusion injury. Life Sci;82(23-24):1196-1202. 2008-06-06 [PMID: 18482739]
Wallace JL, Dicay M, McKnight W et al. Hydrogen sulfide enhances ulcer healing in rats. FASEB J;21(14):4070-6. 2007-12-01 [PMID: 17634391]
Schicho R, Krueger D, Zeller F et al. Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig human colon. Gastroenterology;131(5):1542-52. 2006-11-01 [PMID: 17101327]
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Cystathionase Antibody (4E1-1B7)

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Gene Symbol	CTH
Entrez	1491(Human)
OMIM	219500(Human)
Uniprot	AAH15807(Human)