GCLC Antibody (3H1)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using H00002729-M01	Applications	Species
Stewart A, Glaser E, Bailey WM, Gensel J Immunoglobulin G is Increased in the Injured Spinal Cord in a Sex and Age Dependent Manner Journal of neurotrauma 2022-04-04 [PMID: 35373588] (WB, Mouse)	WB	Mouse
Deka B, Sarma P, Manna P et al. Alliin Enriched Standardized Fraction of Allium Hookeri Regulates the Glucose Homeostasis Via Upregulating Hepatic Glutathione Pool SSRN Electronic Journal 2023-02-17 (WB, Rat)	WB	Rat
Stewart A, Glaser E, Mott CA et al. Advanced Age and Neurotrauma Diminish Glutathione and Impair Antioxidant Defense after Spinal Cord Injury Journal of neurotrauma 2022-04-04 [PMID: 35373589] (WB, Mouse)	WB	Mouse
Kim DH, Jang JH, Kwon OS et al. Nrf2-induced reductive stress favours self-renewal of breast cancer stem-like cells via the FoxO3a-Bmi-1 axis Antioxid. Redox Signal. 2019-11-01 [PMID: 31672029]
Takahashi S, Hisatsune A, Kurauchi Y et al. Polysulfide protects midbrain dopaminergic neurons from MPP+-induced degeneration via enhancement of glutathione biosynthesis. J Pharmacol Sci 2018-04-20 [PMID: 29709269]
Beatty A, Fink LS, Singh T et al. Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer Molecular Cancer Therapeutics 2018-01-01 [PMID: 29021292]
Insulin-like growth factor 1 specifically up-regulates expression of modifier subunit of glutamate-cysteine ligase and enhances glutathione synthesis in SH-SY5Y cells. Takahashi S, Hisatsune A, Kurauchi Y et al. Eur J Pharmacol [PMID: 26687633] (WB, Human)	WB	Human
Sanchez-Martin FJ, Fan Y, Carreira V et al. Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice Toxicol. Sci. 2015-03-29 [PMID: 25820237] (WB, Mouse)	WB	Mouse
Vene R, Cardinali B, Arena G et al. Glycogen Synthase Kinase 3 Regulates Cell Death and Survival Signaling in Tumor Cells under Redox Stress. Neoplasia. 2014-07-31 [PMID: 25246272]
Sugiyama K, Ebinuma H, Nakamoto N et al. Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus. PLoS One. 2014-04-09 [PMID: 24718268]
Fan X, Liu X, Hao S et al. The LEGSKO Mouse: A Mouse Model of Age-Related Nuclear Cataract Based on Genetic Suppression of Lens Glutathione Synthesis. PLoS One. 2012-11-30 [PMID: 23226398]
Li M, Gunter ME, Fukagawa NK. Differential activation of the inflammasome in THP-1 cells exposed to chrysotile asbestos and Libby 'six-mix' amphiboles and subsequent activation of BEAS-2B cells. Cytokine. 2012-09-24 [PMID: 23017228]
Kang H, Hong YB, Kim HJ et al. Bioactive food components prevent carcinogenic stress via Nrf2 activation in BRCA1 deficient breast epithelial cells Toxicology Letters 2012-03-12 [PMID: 22192953] (WB, Human)	WB	Human
Abel EL, Bubel JD, Simper MS et al. Protection against 2-chloroethyl ethyl sulfide (CEES) - Induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway. Toxicol Appl Pharmacol. 2011-06-23 [PMID: 21723306]
Hardwick RN, Fisher CD, Canet MJ et al. Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease. Drug Metab Dispos. 2010-08-30 [PMID: 20805291]
Yang H, Ko K, Xia M et al. Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice. Hepatology 2010-04-01 [PMID: 20146260] (WB, Mouse, Human)	WB	Mouse, Human
Yang Heping, Ramani Komal, Xia Meng et al. Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications. Hepatology (Baltimore, Md.) 2009-01-01 [PMID: 19399914] (WB, Mouse)	WB	Mouse
Show All 17 Publications. Collapse Publications.

Array H00002729-M01

• GCLC Antibodies
• GCLC Lysate
• GCLC Proteins