IER3 Antibody - BSA Free

IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-alpha. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappaB/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 2 applications: IF/IHC, Immunohistochemistry.

Showing Publications 1 - 2 of 2.

Publications using NBP1-76802	Applications	Species
Jordan KR, Sikora MJ, Slansky JE et al. The Capacity of the Ovarian Cancer Tumor Microenvironment to Integrate Inflammation Signaling Conveys a Shorter Disease-free Interval Clinical Cancer Research 2020-12-01 [PMID: 32928797] (Immunohistochemistry)	Immunohistochemistry
Akilov OE, Wu MX, Ustyugova IV et al. Resistance of Sezary cells to TNF-alpha-induced apoptosis is mediated in part by a loss of TNFR1 and a high level of the IER3 expression Exp Dermatol 2012-04-01 [PMID: 22417305] (IF/IHC, Rat)	IF/IHC	Rat

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC		07/05/2012	View Summary Application Immunohistochemistry

Array NBP1-76802

• IER3 Antibodies
• IER3 Proteins