Sirtuin 1/SIRT1 Assay Kit (Fluorometric)

This product is produced by and distributed for Abnova, a company based in Taiwan.

There are seven human sirtuins which have been designated SIRT1-SIRT7. SIRT1, which is located in the nucleus, is the human sirtuin with the greatest homology to yeast Silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. These results have significant implications regarding an important role of SIRT1 in modulating the sensitivity of cells in p53-dependent apoptotic response and the possible effect in cancer therapy. Since the growth suppressive function of p53 is strongly enhanced by DNA damaging reagents, it is expected that inhibitors of SIRT1 may be effective anticancer drugs.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Kits are guaranteed for 6 months from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using KA1366	Applications	Species
Chen C, Ju R, Zhu L et al. Carboxyamidotriazole alleviates muscle atrophy in tumor-bearing mice by inhibiting NF-kB and activating SIRT1. Naunyn Schmiedebergs Arch Pharmacol 2017-04-01 [PMID: 28124088]

Array KA1366

• Sirtuin 1/SIRT1 Antibodies
• Sirtuin 1/SIRT1 ELISA Kits
• Sirtuin 1/SIRT1 Kit
• Sirtuin 1/SIRT1 Lysate
• Sirtuin 1/SIRT1 Proteins
• Sirtuin 1/SIRT1 Proteins and Enzyme