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Sirtuin 1/SIRT1 Antibody (834918) [DyLight 405]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications CyTOF-ready, Flow, ICC/IF
Clone
834918
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC7714U-100UG
Alexa Fluor 405
IC7714V-100UG
Alexa Fluor 488
IC7714G-100UG
Alexa Fluor 532
FAB7714X
Alexa Fluor 594
IC7714T-100UG
Alexa Fluor 647
IC7714R-100UG
Alexa Fluor 700
IC7714N-100UG
Alexa Fluor 750
IC7714S-100UG
Allophycocyanin
FAB7714A
Biotin
FAB7714B
CoraFluor 1
FAB7714CL1
DyLight 350
FAB7714D
DyLight 488
FAB7714K
DyLight 550
FAB7714L
DyLight 594
FAB7714M
DyLight 650
FAB7714W
DyLight 680
FAB7714Y
DyLight 755
FAB7714Z
FITC
FAB7714F
HRP
FAB7714H
Janelia Fluor 525
FAB7714JF525
Janelia Fluor 549
FAB7714I
Janelia Fluor 585
FAB7714JF585
Janelia Fluor 635
FAB7714JF635
Janelia Fluor 646
FAB7714J
Janelia Fluor 669
FAB7714JF669
PE
FAB7714P
PerCP
FAB7714C
Unconjugated
MAB7714
mFluor Violet 450 SE
FAB7714MFV450
mFluor Violet 500 SE
FAB7714MFV500
mFluor Violet 610 SE
FAB7714MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB7714
Carrier Free
MAB7714
Carrier Free
MAB7714-SP
Carrier Free
IC7714S-100UG
Carrier Free
IC7714R-100UG
Carrier Free
IC7714N-100UG
Carrier Free
IC7714G-100UG
Carrier Free
IC7714V-100UG
Carrier Free
IC7714U-100UG
Carrier Free
IC7714T-100UG
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Sirtuin 1/SIRT1 Antibody (834918) [DyLight 405] Summary

Immunogen
E. coli-derived recombinant human Sirtuin 1/SIRT1
Met1-Ser747
Accession # Q96EB6
Specificity
Detects human Sirtuin 1/SIRT1 in ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Sirtuin 2, 3, 5, or 6 is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SIRT1
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Immunocytochemistry
  • Intracellular Staining by Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Sirtuin 1/SIRT1 Antibody (834918) [DyLight 405]

  • EC 3.5.1
  • S. cerevisiae, homolog) 1
  • SIR2alpha
  • SIR2L1
  • SIR2-like protein 1
  • SIRT1
  • Sirtuin 1

Background

The S. cerevisiae silent information regulator 2 (Sir2) protein is an NAD+-dependent histone deacetylase (HDACs) that plays a critical role in transcriptional silencing, genome stability, and longevity (1-2). Part of the Sirtuin family (Sir2, Sir3, Sir3), yeast Sir2 is the founding member of Class III HDACs. A human homologue of Sir2 , SIRT1, regulates the activity of the p53 tumor suppressor and inhibits apoptosis (3-4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SIRT1