SHIP2/INPPL1 Antibody (3E6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

INPPL1 is a phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways with wide reaching effects It plays a central role in regulation of PI3K-dependent insulin signaling and confers resistance to dietary obesity. It is part of a signaling pathway that regulates actin cytoskeleton remodeling. It regulates cell adhesion and cell spreading and acts as a regulator of neuritogenesis. It acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). and mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. It is involved in the EGF signaling pathway.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 10 of 10.

Publications using H00003636-M01	Applications	Species
Antoine M, Vandenbroere I, Ghosh S et al. IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells Cell. Signal. 2020-06-11 [PMID: 32535200] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Ramos AR, Ghosh S, Suhel T et al. Phosphoinositide 5-phosphatases SKIP and SHIP2 in ruffles, the endoplasmic reticulum and the nucleus: An update Adv Biol Regul 2019-10-07 [PMID: 31628071] (ICC/IF, Human)	ICC/IF	Human
Ramos AR, Ghosh S, Dedobbeleer M et al. Lipid phosphatases SKIP and SHIP2 regulate fibronectin-dependent cell migration in glioblastoma FEBS J. 2019-01-29 [PMID: 30695232] (ICC/IF, Human)	ICC/IF	Human
Ramos AR, Ghosh S, Erneux C. The impact of PI 5-phosphatases on phosphoinositides in cell function and human disease. J. Lipid Res. 2018-09-07 [PMID: 30194087] (ICC/IF, Human)	ICC/IF	Human
Chan Wah Hak L, Khan S, Di Meglio I et al. FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis. Nat Cell Biol 2018-07-30 [PMID: 30061681] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Edimo WE, Ramos AR, Ghosh S et al. The SHIP2 interactor Myo1c is required for cell migration in 1321 N1 glioblastoma cells. Biochem. Biophys. Res. Commun. 2016-05-28 [PMID: 27246739] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Edimo WE, Ghosh S, Derua R et al. SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma. J. Cell. Sci. 2016-01-29 [PMID: 26826186] (WB, Human)	WB	Human
Deneubourg L, Elong Edimo W, Moreau C et al. Phosphorylated SHIP2 on Y1135 localizes at focal adhesions and at the mitotic spindle in cancer cell lines. Cell. Signal. 2014-03-03 [PMID: 24561238] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Elong Edimo W, Vanderwinden JM, Erneux C. SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts Adv Biol Regul 2012-09-13 [PMID: 23040614] (ICC/IF, Human)	ICC/IF	Human
McNulty S, Powell K, Erneux C, Kalman D. The Host Phosphoinositide 5-Phosphatase SHIP2 Regulates Dissemination of Vaccinia Virus. J Virol;85(14):7402-7410. 2011-07-01 [PMID: 21543482]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Cedric Asensio	WB	Rat	11/01/2017	View Summary Application Western Blot Sample Tested PC12 cell lysate Species Rat Lot GA061-3E6 Comments Comments Used Ab in PBS-T Milk @1:200. Using Goat-Anti-Mouse-HRP as secondary.

Array H00003636-M01

• SHIP2/INPPL1 Antibodies
• SHIP2/INPPL1 Proteins