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Serpin A3/alpha 1-Antichymotrypsin Antibody

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Immunohistochemistry-Paraffin: Serpin A3/alpha 1-Antichymotrypsin Antibody [NB120-9374] - Formalin fixed paraffin embedded human tonsil stained with alpha-1-Antichymotrypsin antibody (NB120-9374).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Serpin A3/alpha 1-Antichymotrypsin Antibody Summary

Immunogen
alpha-1-antichymotrypsin isolated from human serum.
Localization
Cytoplasmic
Specificity
The is specific against human alpha-1-antichymotrypsin. This stains monocytes and macrophages in human tissues and does not stain any other cell type.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SERPINA3
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:25-1:70
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:25-1:70
Application Notes
IHC-P: recommended incubation time of 30 min at RT.

Reactivity Notes

Cross-reacts with Human. Expected to cross-react with all Mammals due to sequence identity. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
PBS (pH 7.4), 0.2% BSA, Tween-20
Preservative
0.05% Sodium Azide
Purity
Affinity purified

Alternate Names for Serpin A3/alpha 1-Antichymotrypsin Antibody

  • AACTMGC88254
  • ACTGIG25
  • alpha 1-Antichymotrypsin
  • alpha-1-antichymotrypsin
  • antitrypsin), member 3
  • Cell growth-inhibiting gene 24/25 protein
  • growth-inhibiting protein 24
  • growth-inhibiting protein 25
  • member 3
  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
  • serine (or cysteine) proteinase inhibitor, clade A, member 3
  • Serpin A3
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

Background

The protein is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variation in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SERPINA3
Entrez