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Serpin A3/alpha 1-Antichymotrypsin Antibody (213907)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
213907
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price
Carrier Free
MAB1295-SP
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Serpin A3/alpha 1-Antichymotrypsin Antibody (213907) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Serpin A3
aa 26-423
Accession # P01011
Specificity
Detects recombinant human (rh)Serpin A3 in direct ELISAs and Western blots. In these formats, this antibody shows 5 - 25% cross-reactivity with rhSerpins A1 and A5 but no cross-reactivity with rhSerpins C1, D1, or F2.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
SERPINA3
Purity Statement
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB1295 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin A3/alpha 1-Antichymotrypsin Antibody (213907)

  • AACTMGC88254
  • ACTGIG25
  • alpha 1-Antichymotrypsin
  • alpha-1-antichymotrypsin
  • antitrypsin), member 3
  • Cell growth-inhibiting gene 24/25 protein
  • growth-inhibiting protein 24
  • growth-inhibiting protein 25
  • member 3
  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
  • serine (or cysteine) proteinase inhibitor, clade A, member 3
  • Serpin A3
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

Background

Serpin A3, also called alpha 1-Antichymotrypsin, is a major constituent of the plaques associated with Alzheimer’s disease. Deficiency in Serpin A3 activity is associated with chronic obstructive pulmonary disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Serpin A3/alpha 1-Antichymotrypsin Antibody (MAB1295)(5)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Flow Cytometry, ICC, Western Blot.


Filter By Application
Flow Cytometry
(1)
ICC
(1)
Western Blot
(1)
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Human
(3)
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Showing Publications 1 - 5 of 5.
Publications using MAB1295 Applications Species
I Lopez-Fabu, M Garcia-Mac, C Buondelmon, O Burmistrov, N Bonora, P Alonso-Bat, B Morant-Fer, C Vicente-Gu, D Jimenez-Bl, R Quintana-C, E Fernandez, J Llop, P Ramos-Cabr, A Sharaireh, M Guevara-Fe, L Fitzpatric, CD Thompton, TR McKay, S Storch, DL Medina, SE Mole, PO Fedichev, A Almeida, JP Bolaños Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis Nature Communications, 2022-01-27;13(1):536. 2022-01-27 [PMID: 35087090] (ICC, Human) ICC Human
R Masvekar, P Kosa, C Barbour, JL Milstein, B Bielekova Drug library screen identifies inhibitors of toxic astrogliosis Multiple sclerosis and related disorders, 2022-01-04;58(0):103499. 2022-01-04 [PMID: 35030368] (Flow Cytometry, Human) Flow Cytometry Human
Ruturaj Masvekar, Jonathan Phillips, Mika Komori, Tianxia Wu, Bibiana Bielekova Cerebrospinal Fluid Biomarkers of Myeloid and Glial Cell Activation Are Correlated With Multiple Sclerosis Lesional Inflammatory Activity Frontiers in Neuroscience 3/30/2021 [PMID: 33859547]
LM FitzPatric, KE Hawkins, JMKM Delhove, E Fernandez, C Soldati, LF Bullen, A Nohturfft, SN Waddington, DL Medina, JP Bolaños, TR McKay NF-?B Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program Stem Cell Reports, 2018-04-19;0(0):. 4/19/2018 [PMID: 29681545]
Telford G, Brown AP, Kind A, English JS, Pritchard DI Maggot chymotrypsin I from Lucilia sericata is resistant to endogenous wound protease inhibitors. Br. J. Dermatol., 2010-11-29;164(1):192-6. 2010-11-29 [PMID: 21175562] (Western Blot, Human) Western Blot Human

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Bioinformatics

Gene Symbol SERPINA3
Uniprot