SATB2 Antibody - BSA Free

Human special AT-rich sequence-binding protein-2 (SATB2) is a nuclear matrix/scaffold-associated region DNA-binding protein. Like its homolog SATB1, SATB2 selectively binds double-stranded, special AT-rich DNA sequences, but is expressed primarily in a subset of postmitotic, differentiating neurons in the neocortex. Mice deficient in SATB exhibit craniofacial abnormalities and defects in osteoblast differentiation and function. SATB2 also interacts with and enhances the activity of Runx2 and ATF4, two transcription factors that regulate osteoblast differentiation, indicating that SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Recent experiments have shown that SATB2 interacts with histone deacetylase 1 and metastasis-associated protein 2, two proteins that are involved in chromatin remodeling, suggesting that SATB2 may also be involved in mediating epigenetic influences during cortical development. At least two isoforms of SATB2 are known to exist. This SATB2 antibody will not cross-react with SATB1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Chemotaxis.

Showing Publication 1 - 1 of 1.

Publication using NBP1-76912	Applications	Species
Guo Q, Wang Y, Wang Q et al. In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes Pediatric research 2022-08-26 [PMID: 36028553] (Chemotaxis, Mouse)	Chemotaxis	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Ranveer Singh	ChIP	Human	06/25/2014	View Summary Application Chromatin Immunoprecipitation Sample Tested Cross-linked chromatin from HEK 293T cells Species Human

Array NBP1-76912

• SATB2 Antibodies
• SATB2 Proteins