Recombinant Human RNF34 His Protein

RNF34contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. Recombinant human RNF34 protein, fused to His-tag at N-terminus, was expressed in E.coli.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using NBP2-23440	Applications	Species
Francesca M Pramotton, Asra Abukar, Chantelle Hudson, James Dunbar, Andrew Potterton, Simone Tonnicchia, Andrea Taddei, Edoardo Mazza, Costanza Giampietro DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions. Mechanisms of ageing and development 2023-07-10 [PMID: 37301518]
Li, X;Jiang, Q;Song, G;Barkestani, MN;Wang, Q;Wang, S;Fan, M;Fang, C;Jiang, B;Johnson, J;Geirsson, A;Tellides, G;Pober, JS;Jane-Wit, D; A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells Nature communications 2023-05-24 [PMID: 37225719]
Szymanska K, Boldt K, Logan CV, Adams M Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1 Elife 2022-02-16 [PMID: 35170427]

Array NBP2-23440

• RNF34 Antibodies
• RNF34 Lysates
• RNF34 Proteins