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RNase L Antibody (2E9) [DyLight 755]

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Product Details

Summary
Reactivity Hu, Ha, Pm, Mu(-), Rt(-)Species Glossary
Applications WB, ELISA, IHC, KO
Clone
2E9
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 755

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RNase L Antibody (2E9) [DyLight 755] Summary

Immunogen
Purified full-length recombinant human RNaseL produced in insect cells. [UniProt# Q05823]
Localization
Cytoplasmic and Mitochondrial.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
RNASEL
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockout Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

This antibody does not react with mouse or rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for RNase L Antibody (2E9) [DyLight 755]

  • 2-5A-dependent ribonuclease
  • 2-5A-dependent RNase
  • 2'-5'-oligoisoadenylate synthetase-dependent
  • EC 3.1.26.-
  • HPC1
  • interferon-induced 2-5A-dependent RNase
  • MGC104972
  • MGC133329
  • PRCA1
  • prostate cancer 1
  • Ribonuclease 4
  • ribonuclease L (2'-5'-oligoisoadenylate synthetase-dependent)
  • Ribonuclease L
  • RNase L
  • RNS4DKFZp781D08126

Background

RNase L is a virally induced endoribonuclease that is also the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation through total RNA degradation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L is thought to function in counteracting prostate cancer, via apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol RNASEL