ABCE1 Antibody - BSA Free

ABCE1 (ATP-binding cassette sub-family E member 1), also named RLI or HP68, belongs to ABC transporter superfamily/ABCE family and is composed of two nucleotide binding domains and an N-terminal Fe-S binding domain. ABCE1 heterodimerizes with RNASEL leading to its inhibition and has the ability to associates with HIV-1 Vif, HIV-1, HIV-2 and SIV Gag proteins. Evolutionarily highly conserved, ABCE1 localize to cytoplasm/mitochondrion as well as to virus formation clusters at plasma membrane and its highest expression has been observed in brain, kidney, prostate etc. where it gets activated by HIV-1 or EMCV (encephalomyocarditis virus). Originally identified as an RNase L inhibitor, ABCE1 has now been implicated in more fundamental processes of translation and ribosome biogenesis, and can regulate functions including viral infection/assembly of immature HIV-1 capsids, tumor cell proliferation, anti-apoptosis and is also a candidate for tumor-suppressor protein.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Monkey.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 6 of 6.

Publications using NB400-116	Applications	Species
Wu Z, Wang Y, Lim J et al. Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy Cell Metab. 2018-05-18 [PMID: 29861391] (WB, Human)	WB	Human
Toompuu M, Karblane K, Pata P et al. ABCE1 is essential for S phase progression in human cells. Cell Cycle. 2016-03-17 [PMID: 26985706] (ICC/IF, Human)	ICC/IF	Human
Desmet E, Anguish L, Parker J Virus-mediated compartmentalization of the host translational machinery. MBio 2014-09-16 [PMID: 25227463] (WB, ICC/IF, Monkey)	WB, ICC/IF	Monkey
Evgeniya V Smirnova, Therese S Collingwood, Catherine Bisbal, Oxana M Tsygankova, Marina Bogush, Judy L Meinkoth, Earl E Henderson, Roland S Annan, Alexander Y Tsygankov TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion. Virology 2008-03-19 [PMID: 18006034]
Chen, ZQ et al. The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors. J Biol Chem;281(11):7452-7. 2006-03-17 [PMID: 16421098]

Array NB400-116

• ABCE1 Antibodies
• ABCE1 Lysates
• ABCE1 Protein