Species: Hu, Ha, Pm, Mu(-), Rt(-)
Applications: WB, ELISA, IHC, KO
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Ca
Applications: WB
Host: Rabbit Monoclonal
Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: AC
Description
RNase L is a virally induced endoribonuclease that is also the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation through total RNA degradation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L is thought to function in counteracting prostate cancer, via apoptosis.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
6041 |
| Alternate Names |
- 2-5A-dependent ribonuclease
- 2-5A-dependent RNase
- 2'-5'-oligoisoadenylate synthetase-dependent
- EC 3.1.26.-
- HPC1
- interferon-induced 2-5A-dependent RNase
- MGC104972
- MGC133329
- PRCA1
- prostate cancer 1
- Ribonuclease 4
- ribonuclease L (2'-5'-oligoisoadenylate synthetase-dependent)
- Ribonuclease L
- RNase L
- RNS4DKFZp781D08126
|
