RNA Polymerase II/POLR2A Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

POLR2A (DNA-directed RNA Polymerase II subunit RPB1; also subunit A) is a 200‑220 kDa member of the RNA polymerase beta -chain family of proteins. It is ubiquitously expressed and represents the largest subunit of RNA polymerase II, the catalytic mechanism for the synthesis of mRNA. Human POLR2A is 1970 amino acids (aa) in length. It contains an N-terminus with six RNA polymerase domains (aa 15‑1079), and a C-terminus (CTD) with 52 seven aa repeats (‑YSPTSPS‑) that serve as a platform for polymerase subunit interaction. When these sequences are hyperphosphorylated, this subunit is called RNA pol IIo; when hypophosphorylated, the subunit becomes RNA pol IIa. Isoforms exist that show a 60 aa substitution for aa 1‑95, a 24 aa substitution for aa 1‑445, and an Arg substitution for aa 1498‑1536. Full-length human and mouse POLR2A sequences differ by only one amino acid (Thr1856Ala).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA Control.

Showing Publication 1 - 1 of 1.

Publication using AF6160	Applications	Species
Gronke, K;Nguyen, M;Santamaria, N;Schumacher, J;Yang, Y;Sonnert, N;Leopold, S;Martin, AL;Hallet, R;Richter, K;Schubert, DA;Daniel, GM;Dylus, D;Forkel, M;Vieira, SM;Schwinge, D;Schramm, C;Lassen, KG;Piali, L;Palm, NW;Bieniossek, C;Kriegel, MA; Human Th17- and IgG3-associated autoimmunity induced by a translocating gut pathobiont bioRxiv : the preprint server for biology 2023-07-01 [PMID: 37425769] (ELISA Control, Human)	ELISA Control	Human

Array AF6160

• RNA Polymerase II/POLR2A Antibodies
• RNA Polymerase II/POLR2A Proteins