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Reg1A Antibody (431202) [Alexa Fluor® 488]

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AGS human gastric adenocarcinoma cell line was stained with Rat Anti-Human Reg1A Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # IC4937G, filled histogram) or isotype control antibody (Catalog # IC0041G, ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
431202
Clonality
Monoclonal
Host
Rat
Conjugate
Alexa Fluor 488

Order Details

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Reg1A Antibody (431202) [Alexa Fluor® 488] Summary

Immunogen
E. coli-derived recombinant human Reg1A
Gln23-Asn166
Accession # P05451
Specificity
Detects human Reg1A in Western blots. Shows 5% cross-reactivity with recombinant human (rh) Reg1B and no cross-reactivity with rhReg3A, recombinant mouse Reg1, or recombinant rat Reg1.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
REG1A
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Reg1A Antibody (431202) [Alexa Fluor® 488]

  • ICRF
  • Islet cells regeneration factor
  • Islet of Langerhans regenerating protein
  • lithostathine-1-alpha
  • P19
  • pancreatic stone protein, secretory
  • Pancreatic thread protein
  • protein-X
  • PSP
  • PSPS
  • PSPS1
  • PTP
  • REG
  • Reg1A
  • REG-1-alpha
  • Regenerating islet-derived protein 1-alpha
  • Regenerating protein I alpha

Background

Human Reg1A, also known as Reg1 alpha , PTP, PSP and Lithostathine, is a 16-22 kDa, variably glycosylated member of the Reg (Regenerating) family, C-type lectin superfamily of molecules. It is further classified as a type I subfamily member based on gene organization and expression pattern. These are four Reg subfamilies spread across multiple species, with three (or four) additional human Reg family genes assigned to three of the subfamilies. Reg1A is secreted, and circulates as either a monomer, dimer, or tetramer. Once secreted, Reg1A may undergo proteolysis with removal of the N-terminal 11 amino acids (aa). This renders it insoluble with subsequent fibril formation. Reg1A is typically inducible, and human cells reported to express Reg1A include pancreatic islet beta -cells, neurons, intestinal Paneth cells, stomach Chief cells, cardiomyocytes, salivary duct epithelium and antral endocrine cells of the stomach. Reg1A has proliferative effects on multiple cell types, and likely serves as an anti-inflammatory agent. This is presumably mediated by binding to its receptor, EXTL3. Mature human Reg1A (aa 23-166) shares 75%, 69% and 88% aa sequence identity with mouse RegI,rat Reg, and human Reg1B, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol REG1A
Uniprot