Recombinant Mouse BMP-7 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP-1), is a widely expressed TGF-beta superfamily member with important functions during embryogenesis, in the adult, and in disease (1, 2). Mouse BMP-7 is synthesized with a 29 amino acid (aa) signal sequence, a 262 aa propeptide, and a 139 aa growth factor domain (3). The growth factor domain of mouse BMP-7 shares 98% and 100% aa sequence identity with human and rat BMP-7, respectively. The BMP-7 propeptide is cleaved intracellularly but remains in association with the growth factor domain. BMP-7 is subsequently secreted as a tetramer that consists of two propeptides and two disulfide-linked growth factor domains (4, 5). Mature BMP-7 can also form disulfide-linked heterodimers with BMP-2 or BMP-4, complexes that show increased potency and range of activity compared to BMP-7 homodimers (6-8). The presence of the propeptides in the BMP-7 tetramer does not diminish the bioactivity of the growth factor domains (5). Secreted BMP-7 is immobilized in the extracellular matrix as a result of interactions between the propeptide and matrix Fibrillin (4). BMP-7 exerts its biological effects through the type 2 receptors Activin RIIA, Activin RIIB, and BMPR-II and the type 1 receptors Activin RIA, BMPR-IA, and BMPR-IB (2, 5). BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (9, 10), inhibits the branching of prostate epithelium (11), and antagonizes epithelial-mesenchymal transition (EMT) (12-14). In pathological conditions, BMP-7 inhibits tumor growth and metastasis (13), ameliorates fibrotic damage in nephritis (12), and promotes neuroregeneration following brain ischemia (15).

We have publications tested in 4 confirmed species: Human, Mouse, Rat, N/A.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 10 of 21. Show All 21 Publications. Collapse Publications.

Publications using 5666-BP/CF	Applications	Species
M Moulis, SVM Runser, L Glorieux, N Dauguet, C Vanderaa, L Gatto, D Tyteca, P Henriet, FM Spagnoli, D Iber, CE Pierreux Identification and implication of tissue-enriched ligands in epithelial-endothelial crosstalk during pancreas development Scientific Reports, 2022-07-21;12(1):12498. 2022-07-21 [PMID: 35864120] (Bioassay, Mouse)	Bioassay	Mouse
T Yamamoto, Z Diao, M Murakami, F Shimokawa, T Matsui, M Funaba Factors affecting the induction of uncoupling protein 1 in C2C12 myogenic cells Cytokine, 2022-06-20;157(0):155936. 2022-06-20 [PMID: 35738051] (Bioassay, Mouse)	Bioassay	Mouse
N Habeeb, S Najafi, JC Perron Assessment of BMP responses in an in vitro model of acute ethanol toxicity MethodsX, 2022-02-06;9(0):101631. 2022-02-06 [PMID: 35242615] (N/A)		N/A
X Hu, H Wang, GG Tian, C Hou, B Xu, X Zhao, Y Zhao, Q Fang, X Li, L He, X Chen, S Li, J Wu Offspring production of haploid spermatid-like cells derived from mouse female germline stem cells with chromatin condensation Cell & bioscience, 2022-01-04;12(1):5. 2022-01-04 [PMID: 34983631] (Bioassay, Mouse)	Bioassay	Mouse
MA Cortez, F Masrorpour, C Ivan, J Zhang, A Younes, Y Lu, MR Estecio, HB Barsoumian, H Menon, MDS Caetano, R Ramapriyan, JE Schoenhals, X Wang, F Skoulidis, MD Wasley, G Calin, P Hwu, JW Welsh Bone morphogenetic protein 7 promotes resistance to immunotherapy Nat Commun, 2020-09-24;11(1):4840. 2020-09-24 [PMID: 32973129] (Bioassay, Mouse)	Bioassay	Mouse
RL Wu, G Sedlmeier, L Kyjacova, A Schmaus, J Philipp, W Thiele, BK Garvalov, JP Sleeman Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells Sci Rep, 2018-10-08;8(1):14913. 2018-10-08 [PMID: 30297743] (Bioassay, Mouse)	Bioassay	Mouse
VM Jovanovic, A Salti, H Tilleman, K Zega, MM Jukic, H Zou, RH Friedel, N Prakash, S Blaess, F Edenhofer, C Brodski BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells J. Neurosci., 2018-01-10;0(0):. 2018-01-10 [PMID: 29321139] (Bioassay, Human)	Bioassay	Human
Y Jin, X Cheng, J Lu, X Li Exogenous BMP-7 Facilitates the Recovery of Cardiac Function after Acute Myocardial Infarction through Counteracting TGF-?1 Signaling Pathway Tohoku J. Exp. Med., 2018-01-01;244(1):1-6. 2018-01-01 [PMID: 29279455] (In Vivo, Rat)	In Vivo	Rat
Y Chen, H Xu, G Lin Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse Cell Discov, 2017-12-19;3(0):17046. 2017-12-19 [PMID: 29263795] (Bioassay, Mouse)	Bioassay	Mouse
M Awazu, M Nagata, M Hida BMP7 dose-dependently stimulates proliferation and cadherin-11 expression via ERK and p38 in a murine metanephric mesenchymal cell line Physiol Rep, 2017-08-01;5(16):. 2017-08-01 [PMID: 28867673] (Bioassay, Mouse)	Bioassay	Mouse
Y Hou, T Kitaguchi, R Kriszt, YH Tseng, M Raghunath, M Suzuki Ca(2+)-associated triphasic pH changes in mitochondria during brown adipocyte activation Mol Metab, 2017-05-31;6(8):797-808. 2017-05-31 [PMID: 28752044] (Bioassay, Mouse)	Bioassay	Mouse
S Dharmaraja, DL Fisk, CM Sorenson, N Sheibani, TL Belecky-Ad Microglia activation is essential for BMP7-mediated retinal reactive gliosis J Neuroinflammation, 2017-04-05;14(1):76. 2017-04-05 [PMID: 28381236] (Bioassay, Mouse)	Bioassay	Mouse
MM Mata-Miran, GJ Vazquez-Za, M Rojas-Lope, V Sanchez-Mo, DG Perez-Ishi, RJ Delgado-Ma Morphological, molecular and FTIR spectroscopic analysis during the differentiation of kidney cells from pluripotent stem cells Biol. Res., 2017-04-04;50(1):14. 2017-04-04 [PMID: 28376862] (Bioassay, Mouse)	Bioassay	Mouse
Yorgan T, Peters S, Jeschke A, Benisch P, Jakob F, Amling M, Schinke T The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5. J Bone Miner Res, 2015-06-08;30(7):1175-83. 2015-06-08 [PMID: 25640331] (Bioassay, Mouse)	Bioassay	Mouse
Davies , Jamie A, Hohenstein , Peter, Chang , C-Hong, Berry , Rachel A self-avoidance mechanism in patterning of the urinary collecting duct tree. BMC Dev Biol, 2014-09-10;14(0):35. 2014-09-10 [PMID: 25205115] (Bioassay, Mouse)	Bioassay	Mouse
Kiso , Honoka, Takahashi , Katsu, Saito , Kazuyuki, Togo , Yumiko, Tsukamoto , Hiroko, Huang , Boyen, Sugai , Manabu, Shimizu , Akira, Tabata , Yasuhiko, Economides , Aris N, Slavkin , Harold C, Bessho , Kazuhisa Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations. PLoS ONE, 2014-05-09;9(5):e96938. 2014-05-09 [PMID: 24816837] (In Vivo, Mouse)	In Vivo	Mouse
Heinonen A, Rahman M, Dogbevia G, Jakobi H, Wolfl S, Sprengel R, Schwaninger M Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7. BMC Neurosci, 2014-03-11;15(0):38. 2014-03-11 [PMID: 24618040] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Mong J, Panman L, Alekseenko Z, Kee N, Stanton L, Ericson J, Perlmann T Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells. Stem Cells, 2014-03-01;32(3):609-22. 2014-03-01 [PMID: 24549637] (Bioassay, Mouse)	Bioassay	Mouse
Brown A, Muthukrishnan S, Guay J, Adams D, Schafer D, Fetting J, Oxburgh L Role for compartmentalization in nephron progenitor differentiation. Proc Natl Acad Sci U S A, 2013-03-04;110(12):4640-5. 2013-03-04 [PMID: 23487745] (Bioassay, Mouse)	Bioassay	Mouse
Chen , Jiekai, Liu , He, Liu , Jing, Qi , Jing, Wei , Bei, Yang , Jiaqi, Liang , Hanquan, Chen , You, Chen , Jing, Wu , Yaran, Guo , Lin, Zhu , Jieying, Zhao , Xiangjie, Peng , Tianran, Zhang , Yixin, Chen , Shen, Li , Xuejia, Li , Dongwei, Wang , Tao, Pei , Duanqing H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2012-12-02;45(1):34-42. 2012-12-02 [PMID: 23202127] (Bioassay, Mouse)	Bioassay	Mouse
Tramullas M, Lantero A, Diaz A, Morchon N, Merino D, Villar A, Buscher D, Merino R, Hurle JM, Izpisua-Belmonte JC, Hurle MA BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation. J. Neurosci., 2010-01-27;30(4):1502-11. 2010-01-27 [PMID: 20107078] (Bioassay, Mouse)	Bioassay	Mouse
Show All 21 Publications. Collapse Publications.

Array 5666-BP/CF

• BMP-7 Antibodies
• BMP-7 ELISA Kits
• BMP-7 Lysate
• BMP-7 Proteins
• BMP-7 Proteins and Enzymes
• BMP-7 ELISAs