Name: Recombinant Human VEGFR2/KDR Fc Chimera Protein, CF
Brand: Novus Biologicals
SKU: 357-KD/CF
Price: 434 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Bioactivity
Format	Carrier-Free

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS.
Purity	>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions	Reconstitute at 100 μg/mL in sterile PBS.

Publications using 357-KD/CF	Applications	Species
M Chuai, G Serrano Ná, M Serra, L Mahadevan, CJ Weijer Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo Science Advances, 2023-01-04;9(1):eabn5429. 2023-01-04 [PMID: 36598979] (Bioassay, Chick)	Bioassay	Chick
AV Yagolovich, AA Artykov, AA Isakova, YV Vorontsova, DA Dolgikh, MP Kirpichnik, ME Gasparian Optimized Heterologous Expression and Efficient Purification of a New TRAIL-Based Antitumor Fusion Protein SRH-DR5-B with Dual VEGFR2 and DR5 Receptor Specificity International Journal of Molecular Sciences, 2022-05-24;23(11):. 2022-05-24 [PMID: 35682540] (ELISA Capture, Human)	ELISA Capture	Human
L Lu, H Chen, L Wang, L Zhao, Y Cheng, A Wang, F Wang, X Zhang A Dual Receptor Targeting- and BBB Penetrating- Peptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma Int J Nanomedicine, 2020-11-12;15(0):8875-8892. 2020-11-12 [PMID: 33209022] (SPR, Human)	SPR	Human
K Fujiwara, S Sasawatari, S Nakai, K Imaeda, S Nagai, Y Matsuno, K Hatanaka, Y Hatanaka, S Takenaka, N Okada Predicting the Efficacy and Safety of TACTICs (Tumor Angiogenesis-Specific CAR-T Cells Impacting Cancers) Therapy for Soft Tissue Sarcoma Patients Cancers, 2020-09-23;12(10):. 2020-09-23 [PMID: 32977646] (Bioassay, Human)	Bioassay	Human
SB Mamer, A Wittenkell, PI Imoukhuede VEGF-A splice variants bind VEGFRs with differential affinities Sci Rep, 2020-09-02;10(1):14413. 2020-09-02 [PMID: 32879419] (Bioassay, Surface Plasmon Resonance, Human, N/A)	Bioassay, Surface Plasmon Resonance	Human, N/A
H Seo, H Masuda, K Asagoshi, T Uchiki, S Kawata, G Sasaki, T Yabuki, S Miyai, N Takahashi, SI Hashimoto, A Sawada, A Takaiwa, C Koyama, K Tamai, K Kurosawa, KY Lin, K Ohta, Y Nakazaki Streamlined human antibody generation and optimization by exploiting designed immunoglobulin loci in a B cell line Cell. Mol. Immunol., 2020-05-26;0(0):. 2020-05-26 [PMID: 32457406] (Mouse)		Mouse
F Njau, N Shushakova, H Schenk, VC Wulfmeyer, R Bollin, J Menne, H Haller Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice PLoS ONE, 2020-01-14;15(1):e0218494. 2020-01-14 [PMID: 31935212] (Bioassay, Human)	Bioassay	Human
Ö Uslu, J Herold, S M Kanse VEGF-A-Cleavage by FSAP and Inhibition of Neo-Vascularization Cells, 2019-11-06;8(11):. 2019-11-06 [PMID: 31698750] (Bioassay, Human)	Bioassay	Human
JA Buczek-Tho, CB Rich, MA Nugent Hypoxia Induced Heparan Sulfate Primes the Extracellular Matrix for Endothelial Cell Recruitment by Facilitating VEGF-Fibronectin Interactions Int J Mol Sci, 2019-10-12;20(20):. 2019-10-12 [PMID: 31614727] (Bioassay, Human)	Bioassay	Human
Y Zhang, L Yong, Y Luo, X Ding, D Xu, X Gao, S Yan, Q Wang, J Luo, D Pu, J Zou Enhancement of HIFU ablation by sonosensitizer-loading liquid fluorocarbon nanoparticles with pre-targeting in a mouse model Sci Rep, 2019-05-06;9(1):6982. 2019-05-06 [PMID: 31061456] (Bioassay, Human)	Bioassay	Human
CP Miller, C Tsuchida, Y Zheng, J Himmelfarb, S Akilesh A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis Neoplasia, 2018-05-07;20(6):610-620. 2018-05-07 [PMID: 29747161] (Bioassay, Human)	Bioassay	Human
Y Li, JA Hickson, DJ Ambrosi, DL Haasch, KD Foster-Duk, LJ Eaton, EL Digiammari, SC Panchal, F Jiang, SR Mudd, C Zhang, SS Akella, W Gao, SL Ralston, L Naumovski, J Gu, SE Morgan-Lap ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models Mol. Cancer Ther., 2018-03-28;0(0):. 2018-03-28 [PMID: 29592882] (ELISA (Standard))	ELISA (Standard)
SB Mamer, S Chen, JC Weddell, A Palasz, A Wittenkell, M Kumar, PI Imoukhuede Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics Sci Rep, 2017-11-27;7(1):16439. 2017-11-27 [PMID: 29180757] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Malara N, Trunzo V, Musolino G, Aprigliano S, Rotta G, Macrina L, Limongi T, Gratteri S, Di Fabrizio E, Renzulli A, Fini M, Mollace V Soluble CD54 induces human endothelial cells ex vivo expansion useful for cardiovascular regeneration and tissue engineering application. Int J Cardiol Heart Vasc, 2015-01-09;6(0):48-53. 2015-01-09 [PMID: 28785626] (Bioassay, Human)	Bioassay	Human
ME LeBlanc, W Wang, X Chen, NB Caberoy, F Guo, C Shen, Y Ji, H Tian, H Wang, R Chen, W Li Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy J. Exp. Med, 2017-03-22;0(0):. 2017-03-22 [PMID: 28330905] (Bioassay)	Bioassay
J Wang, B Qin, X Chen, WR Wagner, FS Villanueva Ultrasound Molecular Imaging of Angiogenesis Using Vascular Endothelial Growth Factor-Conjugated Microbubbles Mol. Pharm., 2017-02-15;14(3):781-790. 2017-02-15 [PMID: 28165246] (Bioassay)	Bioassay
Kun Ding Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration MAbs, 2017-02-01;0(0):0. 2017-02-01 [PMID: 27929753] (Bioassay)	Bioassay
Naoki Okada Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research Mol Ther Oncolytics, 2016-11-16;3(0):16024. 2016-11-16 [PMID: 27909701] (Bioassay, Mouse)	Bioassay	Mouse
Marc G Achen Differential receptor binding and regulatory mechanisms for the lymphangiogenic growth factors VEGF-C and VEGF-D J. Biol. Chem., 2016-11-16;0(0):. 2016-11-16 [PMID: 27852824] (Bioassay)	Bioassay
Kyu-Yeon Han, Jin-Hong Chang, Hyun Lee, Dimitri T Azar Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis. Investigative Ophthalmology & Visual Science, 2016-06-01;0(0):1552-5783. 2016-06-01 [PMID: 27327585] (Enzyme Assay, Human)	Enzyme Assay	Human
Teran M, Nugent M Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity. J Biol Chem, 2015-05-15;290(26):16451-62. 2015-05-15 [PMID: 25979342] (Bioassay, Human)	Bioassay	Human
Fleetwood F, Klint S, Hanze M, Gunneriusson E, Frejd F, Stahl S, Lofblom J Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity. Sci Rep, 2014-12-17;4(0):7518. 2014-12-17 [PMID: 25515662] (Bioassay)	Bioassay
Maertens L, Erpicum C, Detry B, Blacher S, Lenoir B, Carnet O, Pequeux C, Cataldo D, Lecomte J, Paupert J, Noel A Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis. PLoS ONE, 2014-09-15;9(9):e106976. 2014-09-15 [PMID: 25222747] (Bioassay, Human)	Bioassay	Human
Qi , Jian Hua, Ebrahem , Quteba, Ali , Mariya, Cutler , Alecia, Bell , Brent, Prayson , Nicholas, Sears , Jonathan, Knauper , Vera, Murphy , Gillian, Anand-Apte , Bela Tissue inhibitor of metalloproteinases-3 peptides inhibit angiogenesis and choroidal neovascularization in mice. PLoS ONE, 2013-03-01;8(3):e55667. 2013-03-01 [PMID: 23469166] (ELISA, Human)	ELISA	Human
Harris , Nicole C, Davydova , Natalia, Roufail , Sally, Paquet-Fifield , Sophie, Paavonen , Karri, Karnezis , Tara, Zhang , You-Fang, Sato , Teruhiko, Rothacker , Julie, Nice , Edouard, Stacker , Steven A, Achen , Marc G The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology. J Biol Chem, 2013-02-12;288(12):8176-86. 2013-02-12 [PMID: 23404505] (Bioassay, Human)	Bioassay	Human
Vascular endothelial growth factor signals through platelet-derived growth factor receptor beta in meningiomas in vitro. Br. J. Cancer, 2012-10-09;107(10):1702-13. 2012-10-09 [PMID: 23047550] (Bioassay)	Bioassay
Lorenzon E, Colladel R, Andreuzzi E, Marastoni S, Todaro F, Schiappacassi M, Ligresti G, Colombatti A, Mongiat M MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway. Oncogene, 2011-10-24;31(26):3136-47. 2011-10-24 [PMID: 22020326] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Goyal A, Pal N, Concannon M, Paul M, Doran M, Poluzzi C, Sekiguchi K, Whitelock JM, Neill T, Iozzo RV Endorepellin, the angiostatic module of perlecan, interacts with both the alpha2beta1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism. J. Biol. Chem., 2011-05-19;286(29):25947-62. 2011-05-19 [PMID: 21596751] (Binding Assay, Human)	Binding Assay	Human
Nishiguchi KM, Kataoka K, Kachi S Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate. PLoS ONE, 2010-10-20;5(10):e13493. 2010-10-20 [PMID: 20975989] (Bioassay, Porcine)	Bioassay	Porcine
Lorquet S, Berndt S, Blacher S, Gengoux E, Peulen O, Maquoi E, Noel A, Foidart JM, Munaut C, Pequeux C Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment. FASEB J., 2010-05-19;24(10):3782-95. 2010-05-19 [PMID: 20484670] (Bioassay, IHC, Human, Mouse)	Bioassay, IHC	Human, Mouse
Rennel ES, Varey AH, Churchill AJ, Wheatley ER, Stewart L, Mather S, Bates DO, Harper SJ VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo. Br. J. Cancer, 2009-08-25;101(7):1183-93. 2009-08-25 [PMID: 19707198] (Bioassay, Human)	Bioassay	Human
Ponticelli S, Marasco D, Tarallo V, Albuquerque RJ, Mitola S, Takeda A, Stassen JM, Presta M, Ambati J, Ruvo M, De Falco S Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1. J. Biol. Chem., 2008-10-15;283(49):34250-9. 2008-10-15 [PMID: 18922791] (Binding Assay, Human)	Binding Assay	Human
Pan Q, Chathery Y, Wu Y, Rathore N, Tong RK, Peale F, Bagri A, Tessier-Lavigne M, Koch AW, Watts RJ Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J. Biol. Chem., 2007-06-16;282(33):24049-56. 2007-06-16 [PMID: 17575273] (Binding Assay, Human)	Binding Assay	Human
Wirzenius M, Tammela T, Uutela M, He Y, Odorisio T, Zambruno G, Nagy JA, Dvorak HF, Yla-Herttuala S, Shibuya M, Alitalo K Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. J. Exp. Med., 2007-05-29;204(6):1431-40. 2007-05-29 [PMID: 17535974] (Bioassay, Porcine)	Bioassay	Porcine
Backer MV, Levashova Z, Patel V, Jehning BT, Claffey K, Blankenberg FG, Backer JM Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes. Nat. Med., 2007-03-11;13(4):504-9. 2007-03-11 [PMID: 17351626] (In Vivo, Mouse)	In Vivo	Mouse
Lake AC, Vassy R, Di Benedetto M, Lavigne D, Le Visage C, Perret GY, Letourneur D Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1. J. Biol. Chem., 2006-10-06;281(49):37844-52. 2006-10-06 [PMID: 17028197] (Bioassay, Human)	Bioassay	Human
Ren WP, Markel DC, Zhang R, Peng X, Wu B, Monica H, Wooley PH Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo. Biomaterials, 2006-06-30;27(30):5161-9. 2006-06-30 [PMID: 16814378] (In Vivo, Mouse)	In Vivo	Mouse
Getmanova EV, Chen Y, Bloom L, Gokemeijer J, Shamah S, Warikoo V, Wang J, Ling V, Sun L Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro. Chem. Biol., 2006-05-01;13(5):549-56. 2006-05-01 [PMID: 16720276] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Oliner J, Min H, Leal J, Yu D, Rao S, You E, Tang X, Kim H, Meyer S, Han SJ, Hawkins N, Rosenfeld R, Davy E, Graham K, Jacobsen F, Stevenson S, Ho J, Chen Q, Hartmann T, Michaels M, Kelley M, Li L, Sitney K, Martin F, Sun JR, Zhang N, Lu J, Estrada J, Kumar R, Coxon A, Kaufman S, Pretorius J, Scully S, Cattley R, Payton M, Coats S, Nguyen L, Desilva B, Ndifor A, Hayward I, Radinsky R, Boone T, Kendall R Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell, 2004-11-01;6(5):507-16. 2004-11-01 [PMID: 15542434] (Functional ELISA, Human)	Functional ELISA	Human
Seo KH, Lee HS, Jung B, Ko HM, Choi JH, Park SJ, Choi IH, Lee HK, Im SY Estrogen enhances angiogenesis through a pathway involving platelet-activating factor-mediated nuclear factor-kappaB activation. Cancer Res., 2004-09-15;64(18):6482-8. 2004-09-15 [PMID: 15374958] (Bioassay, Porcine)	Bioassay	Porcine
Show All 40 Publications. Collapse Publications.

Gene Symbol	KDR
Uniprot	AAC16450()

Recombinant Human VEGFR2/KDR Fc Chimera Protein, CF

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Catalog# & Formulation	Size	Price
Standard Formulation 357-KD-050