Recombinant Human TIM-3 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2, is a 60 kDa member of the TIM family of immune regulating molecules. TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk region (1, 2). Mature human TIM-3 consists of a 181 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail (3). An alternatively spliced isoform is truncated within the mucin-like stalk. Within the ECD, human TIM-3 shares 58% aa sequence identity with mouse and rat TIM-3. TIM-3 is up‑regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8⁺, NK, Treg) (3-10). Its binding to Galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity (11). TIM-3 ligation attenuates CD8⁺ and Th1 cell responses (11-13) and promotes the activity of Treg and myeloid derived suppressor cells (8, 11, 13, 14). In addition, dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens (4). It also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA (7). TIM-3 interactions with Galectin-9 can alternatively trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity (10).

We have publications tested in 3 confirmed species: Human, Mouse, Bacteria.

We have publications tested in 4 applications: Binding Assay, Bioassay, Enzyme Assay, Enzyme Assay Substrate.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using 2365-TM	Applications	Species
CM Lake, K Voss, BM Bauman, K Pohida, T Jiang, G Dveksler, AL Snow TIM-3 drives temporal differences in restimulation-induced cell death sensitivity in effector CD8+ T cells in conjunction with CEACAM1 Cell Death & Disease, 2021-04-14;12(4):400. 2021-04-14 [PMID: 33854046] (Bioassay, Human)	Bioassay	Human
A Riva, E Palma, D Devshi, D Corrigall, H Adams, N Heaton, K Menon, M Preziosi, A Zamalloa, R Miquel, JM Ryan, G Wright, S Fairclough, A Evans, D Shawcross, R Schierwage, S Klein, FE Uschner, M Praktiknjo, K Katzarov, T Hadzhiolov, S Pavlova, M Simonova, J Trebicka, R Williams, S Chokshi Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity Frontiers in Physiology, 2021-03-10;12(0):632502. 2021-03-10 [PMID: 33776793] (Bioassay, Human)	Bioassay	Human
S de Kivit, AI Kostadinov, J Kerperien, ME Morgan, VA Muruzabal, GA Hofman, LMJ Knippels, AD Kraneveld, J Garssen, LEM Willemsen Dietary, nondigestible oligosaccharides and Bifidobacterium breve M-16V suppress allergic inflammation in intestine via targeting dendritic cell maturation J. Leukoc. Biol., 2017-05-11;0(0):. 2017-05-11 [PMID: 28495789] (Bioassay, Human)	Bioassay	Human
Wang S, Cao C, Piao H, Li Y, Tao Y, Zhang X, Zhang D, Sun C, Zhu R, Wang Y, Yuan M, Li D, Du M Tim-3 protects decidual stromal cells from toll-like receptor-mediated apoptosis and inflammatory reactions and promotes Th2 bias at the maternal-fetal interface. 2015-03-11;0(0):. 2015-03-11 [PMID: 25757669] (Bioassay, Human)	Bioassay	Human
Ayala-Lujan , Jorge Lu, Vijayakumar , Vidhya, Gong , Mei, Smith , Rachel, Santiago , Araceli, Ruiz-Perez , Fernando Broad spectrum activity of a lectin-like bacterial serine protease family on human leukocytes. PLoS ONE, 2014-09-24;9(9):e107920. 2014-09-24 [PMID: 25251283] (Enzyme Assay, Enzyme Assay Substrate, Bacteria, Human)	Enzyme Assay, Enzyme Assay Substrate	Bacteria, Human
Kojima R, Ohno T, Iikura M, Niki T, Hirashima M, Iwaya K, Tsuda H, Nonoyama S, Matsuda A, Saito H, Matsumoto K, Nakae S Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line. PLoS ONE, 2014-01-20;9(1):e86106. 2014-01-20 [PMID: 24465902] (Bioassay, Human)	Bioassay	Human
Leitner , Judith, Rieger , Armin, Pickl , Winfried, Zlabinger , Gerhard, Grabmeier-Pfistershammer , Katharin, Steinberger , Peter TIM-3 does not act as a receptor for galectin-9. PLoS Pathog, 2013-03-21;9(3):e1003253. 2013-03-21 [PMID: 23555261] (Bioassay, Mouse)	Bioassay	Mouse
Nebbia G, Peppa D, Schurich A, Khanna P, Singh H, Cheng Y, Rosenberg W, Dusheiko G, Gilson R, Chinaleong J, Kennedy P, Maini M Upregulation of the tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. PLoS ONE, 2012-10-24;7(10):e47648. 2012-10-24 [PMID: 23112829] (Bioassay, Human)	Bioassay	Human
Wu W, Shi Y, Li S, Zhang Y, Liu Y, Wu Y, Chen Z Blockade of Tim-3 signaling restores the virus-specific CD8+ T-cell response in patients with chronic hepatitis B. Eur. J. Immunol., 2012-05-01;42(5):1180-91. 2012-05-01 [PMID: 22539292] (Bioassay, Human)	Bioassay	Human
Ivie SE, Fennessey CM, Sheng J, Rubin DH, McClain MS Gene-trap mutagenesis identifies mammalian genes contributing to intoxication by Clostridium perfringens epsilon-toxin. PLoS ONE, 2011-03-11;6(3):e17787. 2011-03-11 [PMID: 21412435] (Binding Assay, Human)	Binding Assay	Human
Vega-Carrascal I, Reeves EP, Niki T, Arikawa T, McNally P, O'Neill SJ, Hirashima M, McElvaney NG Dysregulation of TIM-3-Galectin-9 Pathway in the Cystic Fibrosis Airways. J. Immunol., 2011-01-24;0(0):. 2011-01-24 [PMID: 21263071] (Bioassay, Enzyme Assay, Human)	Bioassay, Enzyme Assay	Human
Show All 11 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	Binding assay/Protein-protein interaction		08/10/2018	View Summary Application Binding assay/Protein-protein interaction Lot HKG1217021

Array 2365-TM

• TIM-3 Antibodies
• TIM-3 Antibody Pair
• TIM-3 Lysate
• TIM-3 Proteins
• TIM-3 Proteins and Enzymes
• TIM-3 ELISAs