PD-1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Programmed Death-1 (PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses (1). Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or down-regulate T cell activation (CTLA-4 and PD-1) (2). PD-1 is expressed on activated T cells, B cells, myeloid cells, and on a subset of thymocytes. In vitro, ligation of PD-1 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10, and IFN-gamma . In addition, PD-1 ligation also inhibits BCR mediated signaling. PD-1 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases (2, 3).

Two B7 family proteins, PD-L1 (also called B7-H1) and PD-L2 (also known as B7-DC), have been identified as PD-1 ligands. Unlike other B7 family proteins, both
PD‑L1 and PD-L2 are expressed in a wide variety of normal tissues including heart, placenta, and activated spleens (4). The wide expression of PD-L1 and PD-L2 and the inhibitor effects on PD-1 ligation indicate that PD-1 might be involved in the regulation of peripheral tolerance and may help prevent autoimmune diseases (2).

The human PD-1 gene encodes a 288 amino acid (aa) protein with a putative 20 aa signal peptide, a 148 aa extracellular region with one immunoglobulin-like V-type domain, a 24 aa transmembrane domain, and a 95 aa cytoplasmic region. The cytoplasmic tail contains two tyrosine residues that form the immuno-receptor
tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) that are important in mediating PD-1 signaling. Mouse and human PD-1 share approximately 60% aa sequence identity (4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Human, Mouse, Feline, Primate, Primate - Cercocebus atys (Sooty Mangabey), Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 10 applications: Bioassay, ELISA Development, Flow Cytometry, Functional Assay, ICC, IHC, IHC-P, Immunohistochemistry, Neutralization, Western Blot.

Showing Publications 1 - 10 of 65. Show All 65 Publications. Collapse Publications.

Publications using AF1086	Applications	Species
Krenács, L;Krenács, D;Borbényi, Z;Tóth, E;Nagy, A;Piukovics, K;Bagdi, E; Comparison of Follicular Helper T-Cell Markers with the Expression of the Follicular Homing Marker CXCR5 in Peripheral T-Cell Lymphomas-A Reappraisal of Follicular Helper T-Cell Lymphomas International journal of molecular sciences 2023-12-28 [PMID: 38203606] (Immunohistochemistry, Human)	Immunohistochemistry	Human
H�nze, J;Schulte-Herbr�ggen, J;Hofmann, R;Hegele, A; Modulation of immune checkpoint regulators in interferon ? induced urothelial carcinoma and activated T-lymphocyte cells by cytostatics Genes and immunity 2023-05-03 [PMID: 37138100] (Western Blot, Human)	Western Blot	Human
Qing Guo, Shuai Shen, Gefei Guan, Chen Zhu, Cunyi Zou, Jingyuan Cao et al. Cancer cell intrinsic TIM-3 induces glioblastoma progression iScience 11/18/2022 [PMID: 36325060]
J Wu, R Zhu, Z Wang, X Chen, T Xu, Y Liu, M Song, J Jiang, Q Ma, Z Chen, Y Liu, X Wang, M Zhang, M Huang, N Ji Exosomes in malignant pleural effusion from lung cancer patients impaired the cytotoxicity of double-negative T cells Translational Oncology, 2022-10-14;27(0):101564. 2022-10-14 [PMID: 36252282] (Bioassay, Human)	Bioassay	Human
AG Goubet, L Lordello, C Alves Cost, I Peguillet, M Gazzano, MD Mbogning-F, C Thelemaque, C Lebacle, C Thibault, F Audenet, G Pignot, G Gravis, C Helissey, L Campedel, M Roupret, E Xylinas, I Ouzaid, A Dubuisson, M Mazzenga, C Flament, P Ly, V Marty, N Signolle, A Sauvat, T Sbarrato, M Filahi, C Davin, G Haddad, J Bou Khalil, C Bleriot, FX Danlos, G Dunsmore, K Mulder, A Silvin, T Raoult, B Archambaud, S Belhechmi, I Gomperts B, N Cayet, M Moya-Nilge, A Mallet, R Daillere, E Rouleau, C Radulescu, Y Allory, J Fieschi, M Rouanne, F Ginhoux, G Le Teuff, L Derosa, A Marabelle, J VAN Dorp, N VAN Dijk, MS van der He, B Besse, F Andre, M Merad, G Kroemer, JY Scoazec, L Zitvogel, Y Loriot Escherichia coli-specific CXCL13-producing TFH are associated with clinical efficacy of neoadjuvant PD-1 blockade against muscle-invasive bladder cancer Cancer Discovery, 2022-10-05;0(0):. 2022-10-05 [PMID: 35929803] (IHC, Human)	IHC	Human
S Shankar, J Stolp, SC Juvet, J Beckett, PS Macklin, F Issa, J Hester, KJ Wood Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis Nature Communications, 2022-06-03;13(1):3121. 2022-06-03 [PMID: 35660734] (Neutralization, Human)	Neutralization	Human
Fanyi Gan, Chuanfen Zhang, Liang Xia, Senyi Deng Tumor-endogenous PD-1 promotes cell proliferation and predicts poor survival in non-small cell lung cancer Translational Cancer Research 1/1/2022 [PMID: 35261880]
Corinna U. Keber, Marcus Derigs, Carolin Schultz, Moritz Wegner, Susanne Lingelbach, Viktoria Wischmann et al. Cellular and soluble immune checkpoint signaling forms PD-L1 and PD-1 in renal tumor tissue and in blood Cancer Immunology, Immunotherapy 10/1/2022 [PMID: 35184226]
D Rafei-Sham, S Lehr, M Behrens, F Meiss Additive Intralesional Interleukin-2 Improves Progression-Free Survival in a Distinct Subgroup of Melanoma Patients with Prior Progression under Immunotherapy Cancers, 2022-01-21;14(3):. 2022-01-21 [PMID: 35158808] (IHC, Human)	IHC	Human
Anna von Schoenfeld, Peter Bronsert, Michael Poc, Andrew Fuller, Andrew Filby, Stefan Kraft et al. Multiple Immunostainings with Different Epitope Retrievals—The FOLGAS Protocol International Journal of Molecular Sciences 12/25/2021 [PMID: 35008649]
Bo Cheng, Kaikai Ding, Pengxiang Chen, Jianxiong Ji, Tao Luo, Xiaofan Guo et al. Anti‐PD‐L1/TGF‐ beta R fusion protein (SHR‐1701) overcomes disrupted lymphocyte recovery‐induced resistance to PD‐1/PD‐L1 inhibitors in lung cancer Cancer Communications 1/3/2022 [PMID: 34981670]
C Takasu, S Yamashita, Y Morine, K Yoshikawa, T Tokunaga, M Nishi, H Kashihara, T Yoshimoto, M Shimada The role of the immunoescape in colorectal cancer liver metastasis PLoS ONE, 2021-11-19;16(11):e0259940. 2021-11-19 [PMID: 34797860] (IHC, Human)	IHC	Human
Sarkar S, Spencer DA, Barnette P et al. CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques Frontiers in Immunology 2021-10-20 [PMID: 34745131]
Sarkar S, Spencer DA, Barnette P et al. CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques Frontiers in Immunology 10/20/2021 [PMID: 34745131]
Mariana G. Weber, Chara J. Walters-Laird, Amir Kol, Clarissa Santos Rocha, Lauren A. Hirao, Abigail Mende et al. Gut germinal center regeneration and enhanced antiviral immunity by mesenchymal stem/stromal cells in SIV infection JCI Insight 6/22/2021 [PMID: 34014838]
C Glorieux, X Xia, YQ He, Y Hu, K Cremer, A Robert, J Liu, F Wang, J Ling, PJ Chiao, P Huang Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling Redox Biology, 2020-11-03;38(0):101780. 2020-11-03 [PMID: 33171331] (Western Blot, Mouse)	Western Blot	Mouse
C Takasu, M Nishi, K Yoshikawa, T Tokunaga, H Kashihara, T Yoshimoto, M Shimada Impact of sidedness of colorectal cancer on tumor immunity PLoS ONE, 2020-10-12;15(10):e0240408. 2020-10-12 [PMID: 33045001] (IHC, Human)	IHC	Human
R Deng, C Zuo, Y Li, B Xue, Z Xun, Y Guo, X Wang, Y Xu, R Tian, S Chen, Q Liu, J Chen, J Wang, X Huang, H Li, M Guo, X Wang, M Yang, Z Wu, J Wang, J Ma, J Hu, G Li, S Tang, Z Tu, H Ji, H Zhu The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/&beta-catenin signaling pathway Cell. Mol. Immunol., 2020-09-22;0(0):. 2020-09-22 [PMID: 32963356] (Neutralization, Human)	Neutralization	Human
Borbala Gesser, Mads K Rasmussen, Lars Iversen <p>Dimethyl Fumarate Targets MSK1, RSK1, 2 and IKK alpha / beta Kinases and Regulates NF-kappa B /p65 Activation in Psoriasis: A Demonstration of the Effect on Peripheral Blood Mononuclear Cells, Drawn from Two Patients with Severe Psoriasis Before and After Treatment with Dimethyl Fumarate</p> Psoriasis: Targets and Therapy 3/31/2020 [PMID: 32309199]
Octavian Bucur, Feifei Fu, Mike Calderon, Geetha H. Mylvaganam, Ngoc L. Ly, Jimmy Day et al. Nanoscale imaging of clinical specimens using conventional and rapid-expansion pathology Nature Protocols 5/1/2020 [PMID: 32238952]
JE Eckel-Pass, TH Ho, DJ Serie, JC Cheville, R Houston Th, BA Costello, H Dong, ED Kwon, BC Leibovich, AS Parker Concordance of PD-1 and PD-L1 (B7-H1) in paired primary and metastatic clear cell renal cell carcinoma Cancer Med, 2019-12-12;0(0):. 2019-12-12 [PMID: 31829518] (IHC-P, Human)	IHC-P	Human
Gan Wang, Le Wang, Jianlong Zhou, Xiaoxin Xu The Possible Role of PD-1 Protein in Ganoderma lucidum-Mediated Immunomodulation and Cancer Treatment Integr Cancer Ther 10/10/2019 [PMID: 31595795]
Paramita Baruah, Jessica Bullenkamp, Philip O. G. Wilson, Michael Lee, Juan Carlos Kaski, Ingrid E. Dumitriu TLR9 Mediated Tumor-Stroma Interactions in Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinoma Up-Regulate PD-L1 and PD-L2 Frontiers in Immunology 7/16/2019 [PMID: 31379843]
S Yang, J Wei, YH Cui, G Park, P Shah, Y Deng, AE Aplin, Z Lu, S Hwang, C He, YY He m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade Nat Commun, 2019-06-25;10(1):2782. 2019-06-25 [PMID: 31239444] (ICC, IHC, Human)	ICC, IHC	Human
N Taechangam, SS Iyer, NJ Walker, B Arzi, DL Borjesson Mechanisms utilized by feline adipose-derived mesenchymal stem cells to inhibit T lymphocyte proliferation Stem Cell Res Ther, 2019-06-25;10(1):188. 2019-06-25 [PMID: 31238978] (Flow Cytometry, Feline)	Flow Cytometry	Feline
S Li, JM Folkvord, KJ Kovacs, RK Wagstaff, G Mwakalundw, AK Rendahl, EG Rakasz, E Connick, PJ Skinner Low levels of SIV-specific CD8+ T cells in germinal centers characterizes acute SIV infection PLoS Pathog., 2019-03-21;15(3):e1007311. 2019-03-21 [PMID: 30897187] (IHC, Primate - Macaca mulatta (Rhesus Macaque))	IHC	Primate - Macaca mulatta (Rhesus Macaque)
B Li, TN Song, FR Wang, C Yin, Z Li, JP Lin, YQ Meng, HM Feng, T Jing Tumor-derived exosomal HMGB1 promotes esophageal squamous cell carcinoma progression through inducing PD1+ TAM expansion Oncogenesis, 2019-02-22;8(3):17. 2019-02-22 [PMID: 30796203] (Bioassay, Human)	Bioassay	Human
Satoru Senoo, Takashi Ninomiya, Go Makimoto, Kazuya Nishii, Hirohisa Kano, Hiromi Watanabe et al. Rapid and Long-term Response of Pulmonary Pleomorphic Carcinoma to Nivolumab Internal Medicine 4/1/2019 [PMID: 30568113]
M Sampedro-N, A Serrano-So, M Adrados, JM Cameselle-, C Blanco-Car, JM Cabezas-Ag, R Martínez-H, E Martín-Pér, JL Muñoz de N, JÁ Díaz, R García-Cen, J Caneiro-Gó, I Abdulkader, R González-A, M Marazuela Analysis of expression of the PD-1/PD-L1 immune checkpoint system and its prognostic impact in gastroenteropancreatic neuroendocrine tumors Sci Rep, 2018-12-13;8(1):17812. 2018-12-13 [PMID: 30546030] (IHC-P, Human)	IHC-P	Human
William J.J. Finlay, James E. Coleman, Jonathan S. Edwards, Kevin S. Johnson Anti-PD1 ‘SHR-1210ʹ aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement mAbs 1/2/2019 [PMID: 30541416]
MASAAKI NISHI, KOZO YOSHIKAWA, JUN HIGASHIJIMA, TAKUYA TOKUNAGA, HIDEYA KASHIHARA, CHIE TAKASU et al. The Impact of Indoleamine 2,3-dioxygenase (IDO) Expression on Stage III Gastric Cancer Anticancer Research 6/1/2018 [PMID: 29848687]
TUMENJIN ENKHBAT, MASAAKI NISHI, CHIE TAKASU, KOZO YOSHIKAWA, HIGASHIJIMA JUN, TAKUYA TOKUNAGA et al. Programmed Cell Death Ligand 1 Expression Is an Independent Prognostic Factor in Colorectal Cancer Anticancer Research 6/1/2018 [PMID: 29848685]
F Wang, B Li, Y Wei, Y Zhao, L Wang, P Zhang, J Yang, W He, H Chen, Z Jiao, Y Li Tumor-derived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression Oncogenesis, 2018-05-25;7(5):41. 2018-05-25 [PMID: 29799520] (Functional Assay, IHC, Human)	Functional Assay, IHC	Human
S Du, N McCall, K Park, Q Guan, P Fontina, A Ertel, T Zhan, AP Dicker, B Lu Blockade of Tumor-Expressed PD-1 promotes lung cancer growth Oncoimmunology, 2018-01-29;7(4):e1408747. 2018-01-29 [PMID: 29632720] (IHC-P, Human)	IHC-P	Human
W Fan, AJ Demers, Y Wan, Q Li Altered Ratio of T Follicular Helper Cells to T Follicular Regulatory Cells Correlates with Autoreactive Antibody Response in Simian Immunodeficiency Virus-Infected Rhesus Macaques J. Immunol., 2018-04-02;0(0):. 2018-04-02 [PMID: 29610141] (Flow Cytometry, Primate)	Flow Cytometry	Primate
MA Rahman, KM McKinnon, TS Karpova, DA Ball, DJ Venzon, W Fan, G Kang, Q Li, M Robert-Gur Associations of Simian Immunodeficiency Virus (SIV)-Specific Follicular CD8+T Cells with Other Follicular T Cells Suggest Complex Contributions to SIV Viremia Control J. Immunol., 2018-03-05;0(0):. 2018-03-05 [PMID: 29507105] (IHC, Primate)	IHC	Primate
D Amodio, N Cotugno, G Macchiarul, S Rocca, Y Dimopoulos, MR Castrucci, R De Vito, FM Tucci, AB McDermott, S Narpala, P Rossi, RA Koup, P Palma, C Petrovas Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination J. Immunol., 2017-12-13;0(0):. 2017-12-13 [PMID: 29237774] (IHC, Human)	IHC	Human
Marie-Nicole Theodoraki, Saigopalakrishna S. Yerneni, Thomas K. Hoffmann, William E. Gooding, Theresa L. Whiteside Clinical Significance of PD-L1+ Exosomes in Plasma of Head and Neck Cancer Patients Clinical Cancer Research 2/15/2018 [PMID: 29233903]
Zijun Y. Xu-Monette, Jianfeng Zhou, Ken H. Young PD-1 expression and clinical PD-1 blockade in B-cell lymphomas Blood 1/4/2018 [PMID: 29118007]
Antonio Riva, Vishal Patel, Ayako Kurioka, Hannah C Jeffery, Gavin Wright, Sarah Tarff et al. Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease Gut 5/1/2018 [PMID: 29097439]
Jinfeng Cao, Niels J. Brouwer, Kate E. Richards, Marina Marinkovic, Sjoerd van Duinen, Daan Hurkmans et al. PD-L1/PD-1 expression and tumor-infiltrating lymphocytes in conjunctival melanoma Oncotarget 8/15/2017 [PMID: 28903377]
Y Liu, Y Cheng, Y Xu, Z Wang, X Du, C Li, J Peng, L Gao, X Liang, C Ma Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers Oncogene, 2017-07-10;0(0):. 2017-07-10 [PMID: 28692048] (Functional Assay, Neutralization, Human)	Functional Assay, Neutralization	Human
ELV Silveira, KA Rogers, S Gumber, P Amancha, P Xiao, SM Woollard, SN Byrareddy, MM Teixeira, F Villinger Immune Cell Dynamics in Rhesus Macaques Infected with a Brazilian Strain of Zika Virus J. Immunol., 2017-06-30;0(0):. 2017-06-30 [PMID: 28667164] (IHC, Primate - Macaca mulatta (Rhesus Macaque))	IHC	Primate - Macaca mulatta (Rhesus Macaque)
P Martinez-M, K Tran, J Guenaga, G Lindgren, M Àdori, Y Feng, GE Phad, N Vázquez Be, S Bale, J Ingale, V Dubrovskay, S O'Dell, L Pramanik, M Spångberg, M Corcoran, K Loré, JR Mascola, RT Wyatt, GB Karlsson H Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach Immunity, 2017-05-16;46(5):804-817.e7. 2017-05-16 [PMID: 28514687] (IHC, Primate)	IHC	Primate
Joseph M Obeid PD-L1, PD-L2 and PD-1 expression in metastatic melanoma: Correlation with tumor-infiltrating immune cells and clinical outcome Oncoimmunology, 2016-09-20;5(11):e1235107. 2016-09-20 [PMID: 27999753] (IHC-P, Human)	IHC-P	Human
PT Nghiem, S Bhatia, EJ Lipson, RR Kudchadkar, NJ Miller, L Annamalai, S Berry, EK Chartash, A Daud, SP Fling, PA Friedlande, HM Kluger, HE Kohrt, L Lundgren, K Margolin, A Mitchell, T Olencki, DM Pardoll, SA Reddy, EM Shantha, WH Sharfman, E Sharon, She PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma N Engl J Med, 2016-04-19;0(0):. 2016-04-19 [PMID: 27093365] (IHC-P, Human)	IHC-P	Human
Madison Black, Ivraym B. Barsoum, Peter Truesdell, Tiziana Cotechini, Shannyn K. Macdonald-Goodfellow, Margaret Petroff et al. Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis Oncotarget 3/1/2016 [PMID: 26859684]
Vargas-Inchaustegui D, Demers A, Shaw J, Kang G, Ball D, Tuero I, Musich T, Mohanram V, Demberg T, Karpova T, Li Q, Robert-Guroff M Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques. J Immunol, 2016-01-15;196(4):1700-10. 2016-01-15 [PMID: 26773147] (IHC, Primate - Macaca mulatta (Rhesus Macaque))	IHC	Primate - Macaca mulatta (Rhesus Macaque)
Zhang Z, Cheng L, Zhao J, Li G, Zhang L, Chen W, Nie W, Reszka-Blanco N, Wang F, Su L Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion. J Clin Invest, 2015-08-24;125(9):3692-703. 2015-08-24 [PMID: 26301812] (IHC-P, Mouse)	IHC-P	Mouse
Shohei Eto, Kozo Yoshikawa, Masaaki Nishi, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao et al. Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection Gastric Cancer 4/1/2016 [PMID: 26210691]
Yan G. Ni, Xiling Yuan, John A. Newitt, Jon E. Peterson, Carol R. Gleason, Jonathan Haulenbeek et al. Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay The AAPS Journal 7/1/2015 [PMID: 25924887]
Fukazawa Y, Lum R, Okoye AA et al. A B cell follicle sanctuary permits persistent productive SIV infection in elite controllers. Nat Med 2/1/2015 [PMID: 25599132]
Melendreras S, Martinez-Camblor P, Menendez A, Bravo-Mendoza C, Gonzalez-Vidal A, Coto E, Diaz-Corte C, Ruiz-Ortega M, Lopez-Larrea C, Suarez-Alvarez B Soluble co-signaling molecules predict long-term graft outcome in kidney-transplanted patients. PLoS ONE, 2014-12-05;9(12):e113396. 2014-12-05 [PMID: 25478957] (ELISA Development, Human)	ELISA Development	Human
Hong J, Amancha P, Rogers K, Courtney C, Havenar-Daughton C, Crotty S, Ansari A, Villinger F Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection. J Immunol, 2014-06-06;193(2):797-806. 2014-06-06 [PMID: 24907346] (IHC, Primate - Macaca mulatta (Rhesus Macaque))	IHC	Primate - Macaca mulatta (Rhesus Macaque)
Barbara Merelli, Daniela Massi, Laura Cattaneo, Mario Mandalà Targeting the PD1/PD-L1 axis in melanoma: Biological rationale, clinical challenges and opportunities Critical Reviews in Oncology/Hematology 1/1/2014 [PMID: 24029602]
Fatma Çetinözman, Patty M. Jansen, Maarten H. Vermeer, Rein Willemze Differential Expression of Programmed Death-1 (PD-1) in Sézary Syndrome and Mycosis Fungoides Archives of Dermatology 12/19/2012 [PMID: 23247480]
Huan Xu, Dayan Cao, Guoning Guo, Zhihua Ruan, Yuzhang Wu, Yongwen Chen The Intrahepatic Expression and Distribution of BTLA and its Ligand HVEM in patients with HBV-related acute-on-chronic liver failure Diagnostic Pathology 12/1/2012 [PMID: 23067542]
CD4 T follicular helper cell dynamics during SIV infection. J. Clin. Invest., 2012-08-27;122(9):3281-94. 2012-08-27 [PMID: 22922258] (IHC-P, Primate - Macaca mulatta (Rhesus Macaque))	IHC-P	Primate - Macaca mulatta (Rhesus Macaque)
Inti Zlobec, Eva Karamitopoulou, Luigi Terracciano, Salvatore Piscuoglio, Giandomenica Iezzi, Manuele Giuseppe Muraro et al. TIA-1 Cytotoxic Granule-Associated RNA Binding Protein Improves the Prognostic Performance of CD8 in Mismatch Repair-Proficient Colorectal Cancer PLoS ONE 12/10/2010 [PMID: 21179245]
P Minoo, I Zlobec, M Peterson, L Terracciano, A Lugli Characterization of rectal, proximal and distal colon cancers based on clinicopathological, molecular and protein profiles International Journal of Oncology 7/29/2010 [PMID: 20664940]
Elias A Said, Franck P Dupuy, Lydie Trautmann, Yuwei Zhang, Yu Shi, Mohamed El-Far et al. Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection Nature Medicine 4/1/2010 [PMID: 20208540]
Schatton T, Schutte U, Frank NY, Zhan Q, Hoerning A, Robles SC, Zhou J, Hodi FS, Spagnoli GC, Murphy GF, Frank MH Modulation of T-cell activation by malignant melanoma initiating cells. Cancer Res., 2010-01-12;70(2):697-708. 2010-01-12 [PMID: 20068175] (IHC, Human)	IHC	Human
Estes JD, Gordon SN, Zeng M, Chahroudi AM, Dunham RM, Staprans SI, Reilly CS, Silvestri G, Haase AT Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques. J. Immunol., 2008-05-15;180(10):6798-807. 2008-05-15 [PMID: 18453600] (IHC, Primate - Macaca mulatta (Rhesus Macaque), Primate - Cercocebus atys (Sooty Mangabey))	IHC	Primate - Macaca mulatta (Rhesus Macaque), Primate - Cercocebus atys (Sooty Mangabey)
Onlamoon N, Rogers K, Mayne AE, Pattanapanyasat K, Mori K, Villinger F, Ansari AA Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection. Immunology, 2008-02-05;124(2):277-93. 2008-02-05 [PMID: 18266718] (Neutralization, Primate - Macaca mulatta (Rhesus Macaque))	Neutralization	Primate - Macaca mulatta (Rhesus Macaque)
Wan B, Nie H, Liu A, Feng G, He D, Xu R, Zhang Q, Dong C, Zhang JZ Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J. Immunol., 2006-12-15;177(12):8844-50. 2006-12-15 [PMID: 17142787] (ELISA Development, Human)	ELISA Development	Human
Show All 65 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Christopher England	IF	Human	07/09/2016	View Summary Application Immunofluorescence Sample Tested Mouse salivary gland (one injected with human T cells and one with no human T cells) Species Human Lot ICA0714071

Array AF1086

• PD-1 Antibodies
• PD-1 Antibody Pair
• PD-1 Lysate
• PD-1 Proteins
• PD-1 Proteins and Enzymes
• PD-1 ELISAs