Recombinant Human/Mouse/Rat BMP-2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration (1, 2). Human BMP‑2 is synthesized as a 396 amino acid (aa) preproprotein that contains a 23 aa signal sequence, a 259 aa prosegment, and a 114 aa mature region (3). Proteolytic removal of the propeptide enables mature BMP-2 to form active disulfide linked homodimers and heterodimers with BMP-7 (2). Mature monomeric BMP-2 is an 18 kDa glycosylated peptide with seven conserved cysteines that form a cystine knot structure (4). Mature human BMP-2 shares 100% aa sequence identity with mouse and rat BMP-2. It shares 85% aa sequence identity with human BMP-4 and less than 51% with other BMPs. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMPR‑IA, or BMPR‑IB) and a type II receptor (BMP RII or Activin RIIB) (2, 5). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair (6, 7). It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells, and vascular smooth muscle cells (2, 8‑10). BMP-2/BMP-7 heterodimers are significantly more potent than BMP-2 homodimers at inducing bone formation in vivo (11). BMP-2 also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells, and is required for cardiac contractility (12‑15).

We have publications tested in 16 confirmed species: Human, Mouse, Rat, Bovine, Canine, Chicken, Equine, Hamster, N/A, Phallusia mammillata, Porcine, Rabbit, Rats, Transgenic Mouse, Xenopus, Zebrafish.

We have publications tested in 8 applications: Binding Assay, Bioassay, Cell Culture, ELISA (Capture), ELISA Capture, In Vivo, Organoid Culture, Surface Plasmon Resonance.

Showing Publications 1 - 10 of 183. Show All 183 Publications. Collapse Publications.

Publications using 355-BM/CF	Applications	Species
S Das, A Mondal, C Dey, S Chakrabort, R Bhowmik, S Karmakar, A Sengupta ER stress induces upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival The Journal of Biological Chemistry, 2023-02-16;0(0):103031. 2023-02-16 [PMID: 36805334] (Bioassay, Rat)	Bioassay	Rat
Y Hachinohe, M Taira, M Hoshi, D Yoshida, W Hatakeyama, T Sawada, H Kondo Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation International Journal of Molecular Sciences, 2023-01-06;24(2):. 2023-01-06 [PMID: 36674618] (In Vivo, Rat)	In Vivo	Rat
Y Hachinohe, M Taira, M Hoshi, W Hatakeyama, T Sawada, H Kondo Bone Formation on Murine Cranial Bone by Injectable Cross-Linked Hyaluronic Acid Containing Nano-Hydroxyapatite and Bone Morphogenetic Protein Polymers, 2022-12-08;14(24):. 2022-12-08 [PMID: 36559734] (In Vivo, Mouse)	In Vivo	Mouse
Z Shonibare, M Monavarian, K O'Connell, D Altomare, A Shelton, S Mehta, R Jaskula-Sz, R Phaeton, MD Starr, R Whitaker, A Berchuck, AB Nixon, RC Arend, NY Lee, CR Miller, N Hempel, K Mythreye Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer Oncogene, 2022-07-26;40(4):111066. 2022-07-26 [PMID: 35905726] (Bioassay, Human)	Bioassay	Human
R Chowdhury, A Roure, Y le Pétillo, H Mayeur, V Daric, S Darras Highly distinct genetic programs for peripheral nervous system formation in chordates Bmc Biology, 2022-06-27;20(1):152. 2022-06-27 [PMID: 35761237] (Bioassay, Phallusia mammillata)	Bioassay	Phallusia mammillata
M Vora, A Mondal, D Jia, P Gaddipati, M Akel, J Gilleran, J Roberge, C Rongo, J Langenfeld Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans Cell & bioscience, 2022-05-31;12(1):76. 2022-05-31 [PMID: 35641992] (Bioassay, Human)	Bioassay	Human
AP Leinroth, AJ Mirando, D Rouse, Y Kobayahsi, PR Tata, HE Rueckert, Y Liao, JT Long, JV Chakkalaka, MJ Hilton Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations Cell Reports, 2022-05-10;39(6):110785. 2022-05-10 [PMID: 35545045] (Bioassay, Mouse)	Bioassay	Mouse
F Kawecki, J Jann, M Fortin, FA Auger, N Faucheux, J Fradette Preclinical Evaluation of BMP-9-Treated Human Bone-like Substitutes for Alveolar Ridge Preservation following Tooth Extraction International Journal of Molecular Sciences, 2022-03-18;23(6):. 2022-03-18 [PMID: 35328724] (Cell Culture, Human)	Cell Culture	Human
S Nagel, C Pommerenke, C Meyer, RAF MacLeod The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia International Journal of Molecular Sciences, 2022-03-16;23(6):. 2022-03-16 [PMID: 35328612] (Cell Culture, Human)	Cell Culture	Human
I López-Anto, C Contreras-, L Luque-Mart, A Carpintero, P González-M, I Palmero Dynamic regulation of myofibroblast phenotype in cellular senescence Aging Cell, 2022-03-09;0(0):e13580. 2022-03-09 [PMID: 35266275] (Bioassay, Human)	Bioassay	Human
M Moncayo-Do, GA Rico-Llano, DA Garzón-Alv, J Becerra, R Visser, MR Fontanilla The Effect of Pore Directionality of Collagen Scaffolds on Cell Differentiation and In Vivo Osteogenesis Polymers, 2021-09-20;13(18):. 2021-09-20 [PMID: 34578088] (In Vivo, Rats)	In Vivo	Rats
M Zheng, S Erhardt, D Ai, J Wang Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development International Journal of Molecular Sciences, 2021-09-11;22(18):. 2021-09-11 [PMID: 34576009] (Bioassay, Mouse)	Bioassay	Mouse
PR Gajjala, RK Kasam, D Soundarara, D Sinner, SK Huang, AG Jegga, SK Madala Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis JCI Insight, 2021-10-22;0(0):. 2021-10-22 [PMID: 34520400] (Bioassay, Human)	Bioassay	Human
PS Briquez, HM Tsai, EA Watkins, JA Hubbell Engineered bridge protein with dual affinity for bone morphogenetic protein-2 and collagen enhances bone regeneration for spinal fusion Science Advances, 2021-06-11;7(24):. 2021-06-11 [PMID: 34117071] (ELISA Capture, Human)	ELISA Capture	Human
VC Cheung, CY Peng, M Marini?, NJ Sakabe, I Aneas, VJ Lynch, C Ober, MA Nobrega, JA Kessler Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua Cell Reports, 2021-05-18;35(7):109138. 2021-05-18 [PMID: 34010658] (Bioassay, Human)	Bioassay	Human
C Zhou, D Chen, J Ren, D Huang, R Li, H Luo, C Guan, Y Cao, W Wang FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex Journal of Cellular and Molecular Medicine, 2021-02-13;0(0):. 2021-02-13 [PMID: 33580754] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
K Hiraoka, H Inada, K Yanai, N Osumi Bone Morphogenetic Proteins Inhibit Ciliogenesis of Ependymal Cells in Vitro Tohoku J Exp Med, 2020-11-01;252(3):199-208. 2020-11-01 [PMID: 33087680] (Bioassay, Mouse)	Bioassay	Mouse
BE Schwartz, V Rajagopal, C Smith, E Cohick, G Whissell, M Gamboa, R Pai, A Sigova, I Grossman, D Bumcrot, K Sasidharan, S Romeo, A Sehgal, P Pingitore Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings Cells, 2020-10-07;9(10):. 2020-10-07 [PMID: 33036387] (Bioassay, Human)	Bioassay	Human
L Leiendecke, PS Jung, I Krecioch, T Neumann, A Schleiffer, K Mechtler, T Wiesner, AC Obenauf LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma EMBO Mol Med, 2020-10-07;0(0):e12525. 2020-10-07 [PMID: 33026191] (Bioassay, Human)	Bioassay	Human
T Mang, K Kleinschmi, F Ploeger, A Schoeneman, S Lindemann, A Gigout BMPR1A is necessary for chondrogenesis and osteogenesis while BMPR1B prevents hypertrophic differentiation J. Cell. Sci., 2020-08-21;0(0):. 2020-08-21 [PMID: 32764110] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
SK Meurer, O Tezcan, T Lammers, R Weiskirche Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells Cell. Signal., 2020-08-03;74(0):109731. 2020-08-03 [PMID: 32758668] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
L Meng, X Teng, Y Liu, C Yang, S Wang, W Yuan, J Meng, H Chi, L Duan, X Liu Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts J Am Heart Assoc, 2020-07-31;9(15):e016586. 2020-07-31 [PMID: 32750294] (Bioassay, Rat)	Bioassay	Rat
AS Ibrahim, K Hussein, F Wang, M Wan, N Saad, M Essa, I Kim, A Shakoor, LA Owen, MM DeAngelis, M Al-Shabraw Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration J Clin Med, 2020-07-19;9(7):. 2020-07-19 [PMID: 32707711] (Bioassay, Human)	Bioassay	Human
A VanCleave, M Palmer, F Fang, H Torres, T Rodezno, Q Li, K Fuglsby, C Evans, Y Afeworki, A Ross, P Rao, P Leiferman, S Zheng, P Houghton, J Tao Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Oncotarget, 2020-07-07;11(27):2597-2610. 2020-07-07 [PMID: 32676162] (Bioassay, Human)	Bioassay	Human
S Qin, W Wang, Z Liu, X Hua, S Fu, F Dong, A Li, Z Liu, P Wang, L Dai, P Liang, J Zhang, W Cao, X Xiong, H Chen, J Xu Fibrochondrogenic differentiation potential of tendon-derived stem/progenitor cells from human patellar tendon J Orthop Translat, 2019-11-01;22(0):101-108. 2019-11-01 [PMID: 32440505] (Cell Culture, Human)	Cell Culture	Human
A Dudakovic, RM Samsonraj, CR Paradise, C Galeano-Ga, MO Mol, D Galeano-Ga, P Zan, ML Galvan, M Hevesi, O Pichurin, R Thaler, DL Begun, P Kloen, M Karperien, AN Larson, JJ Westendorf, SM Cool, AJ van Wijnen Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2 J. Biol. Chem., 2020-04-24;0(0):. 2020-04-24 [PMID: 32332097] (Bioassay, Mouse)	Bioassay	Mouse
A Krouwels, JD Iljas, AHM Kragten, WJA Dhert, FC Öner, MA Tryfonidou, LB Creemers Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration Int J Mol Sci, 2020-04-14;21(8):. 2020-04-14 [PMID: 32295299] (Bioassay, Human)	Bioassay	Human
S Stich, M Jagielski, A Fleischman, C Meier, P Bussmann, B Kohl, J Schmidt, JP Krüger, M Endres, M Cabraja, K Reimann, D Laue, W Ertel, M Sittinger Degeneration of Lumbar Intervertebral Discs: Characterization of Anulus Fibrosus Tissue and Cells of Different Degeneration Grades Int J Mol Sci, 2020-03-21;21(6):. 2020-03-21 [PMID: 32245213] (Bioassay, Human)	Bioassay	Human
DA Mázala, JS Novak, MW Hogarth, M Nearing, P Adusumalli, CB Tully, NF Habib, H Gordish-Dr, YW Chen, JK Jaiswal, TA Partridge TGF-&beta-driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model JCI Insight, 2020-03-26;5(6):. 2020-03-26 [PMID: 32213706] (Cell Culture, Mouse)	Cell Culture	Mouse
R Castro-Viñ, C Sanjurjo-R, M Piñeiro-Ra, T Hermida-Gó, S Rodríguez-, N Oreiro, J de Toro, I Fuentes, FJ Blanco, S Díaz-Prado Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts Sci Rep, 2020-03-06;10(1):4272. 2020-03-06 [PMID: 32144293] (Cell Culture, Human)	Cell Culture	Human
TJ Broekelman, NK Bodmer, RP Mecham Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1 J. Biol. Chem., 2020-01-27;0(0):. 2020-01-27 [PMID: 31988245] (Surface Plasmon Resonance, N/A)	Surface Plasmon Resonance	N/A
HJ Zhao, HM Chang, C Klausen, H Zhu, Y Li, PCK Leung Bone morphogenetic protein 2 induces the activation of WNT/beta-catenin signaling and human trophoblast invasion through up-regulating BAMBI Cell. Signal., 2019-11-28;0(0):109489. 2019-11-28 [PMID: 31786181] (Cell Culture, Human)	Cell Culture	Human
D Seo, SM Jung, JS Park, J Lee, J Ha, M Kim, SH Park The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway EBioMedicine, 2019-11-01;49(0):55-71. 2019-11-01 [PMID: 31685442] (Cell Culture, Human)	Cell Culture	Human
M Omi, V Kaartinen, Y Mishina Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD signaling pathway J. Biol. Chem., 2019-10-16;0(0):. 2019-10-16 [PMID: 31619522] (Bioassay, Mouse)	Bioassay	Mouse
LR Dutton, CL O' Neill, RJ Medina, DP Brazil No evidence of Gremlin1-mediated activation of VEGFR2 signalling in endothelial cells J. Biol. Chem., 2019-10-11;0(0):. 2019-10-11 [PMID: 31604823] (Cell Culture, Human)	Cell Culture	Human
J Ren, M Smid, J Iaria, DCF Salvatori, H van Dam, HJ Zhu, JWM Martens, P Ten Dijke Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression Breast Cancer Res., 2019-09-18;21(1):109. 2019-09-18 [PMID: 31533776] (Bioassay, Human)	Bioassay	Human
Li, Y Jiang, H Lin, H Shen, J Sohn, PG Alexander, RS Tuan Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production J Orthop Translat, 2019-07-05;18(0):142-153. 2019-07-05 [PMID: 31508317] (In Vivo, Mouse)	In Vivo	Mouse
K Krüger, S Schmid, F Paulsen, A Ignatius, P Klinger, T Hotfiel, B Swoboda, K Gelse Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair Int J Mol Sci, 2019-09-01;20(17):. 2019-09-01 [PMID: 31480518] (Bioassay, Human)	Bioassay	Human
S Moghadasi, A Koontz, G Tseropoulo, L Kerosuo, P Mehrotra, VK Bajpai, SR Selvam, P Lei, ME Bronner, ST Andreadis Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo Sci Rep, 2019-07-05;9(1):9750. 2019-07-05 [PMID: 31278326] (Bioassay, Human)	Bioassay	Human
J Li, A Ayoub, Y Xiu, X Yin, JO Sanders, A Mesfin, L Xing, Z Yao, BF Boyce TGFbeta-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis Nat Commun, 2019-06-26;10(1):2795. 2019-06-26 [PMID: 31243287] (Bioassay, Mouse)	Bioassay	Mouse
M Rosina, F Langone, G Giuliani, A Cerquone P, A Reggio, A Calderone, C Fuoco, L Castagnoli, C Gargioli, G Cesareni Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response Sci Rep, 2019-04-01;9(1):5447. 2019-04-01 [PMID: 30931986] (Bioassay, Mouse)	Bioassay	Mouse
X Zhang, X Lin, T Liu, L Deng, Y Huang, Y Liu Osteogenic Enhancement Between Icariin and Bone Morphogenetic Protein 2: A Potential Osteogenic Compound for Bone Tissue Engineering Front Pharmacol, 2019-03-12;10(0):201. 2019-03-12 [PMID: 30914948] (Bioassay, Human)	Bioassay	Human
HJ Kim, HJ Kim, Y Choi, MK Bae, DS Hwang, SH Shin, JY Lee Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis Int J Mol Sci, 2019-03-22;20(6):. 2019-03-22 [PMID: 30909508] (Bioassay, Mouse)	Bioassay	Mouse
S Supakul, K Yao, H Ochi, T Shimada, K Hashimoto, S Sunamura, Y Mabuchi, M Tanaka, C Akazawa, T Nakamura, A Okawa, S Takeda, S Sato Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing Int J Mol Sci, 2019-03-02;20(5):. 2019-03-02 [PMID: 30832329] (Bioassay, Mouse)	Bioassay	Mouse
WKW Ho, L Freem, D Zhao, KJ Painter, TE Woolley, EA Gaffney, MJ McGrew, A Tzika, MC Milinkovit, P Schneider, A Drusko, F Matthäus, JD Glover, KL Wells, JA Johansson, MG Davey, HM Sang, M Clinton, DJ Headon Feather arrays are patterned by interacting signalling and cell density waves PLoS Biol., 2019-02-21;17(2):e3000132. 2019-02-21 [PMID: 30789897] (Bioassay, Chicken)	Bioassay	Chicken
L Yu, LA Dawson, M Yan, K Zimmel, YL Lin, CP Dolan, M Han, K Muneoka BMP9 stimulates joint regeneration at digit amputation wounds in mice Nat Commun, 2019-02-05;10(1):424. 2019-02-05 [PMID: 30723209] (In Vivo, Mouse)	In Vivo	Mouse
T Karakida, K Onuma, MM Saito, R Yamamoto, T Chiba, R Chiba, Y Hidaka, K Fujii-Abe, H Kawahara, Y Yamakoshi Potential for Drug Repositioning of Midazolam for Dentin Regeneration Int J Mol Sci, 2019-02-04;20(3):. 2019-02-04 [PMID: 30720745] (Bioassay, Porcine)	Bioassay	Porcine
S Hendrikx, S Coso, B Prat-Luri, L Wetterwald, A Sabine, CA Franco, S Nassiri, N Zangger, H Gerhardt, M Delorenzi, TV Petrova Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2 Cell Rep, 2019-01-29;26(5):1227-1241.e6. 2019-01-29 [PMID: 30699351] (Bioassay, Mouse)	Bioassay	Mouse
WN Addison, KC Hall, S Kokabu, T Matsubara, MM Fu, F Gori, R Baron Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation Mol. Cell. Biol., 2019-04-02;0(0):. 2019-04-02 [PMID: 30692273] (Bioassay, Human)	Bioassay	Human
M Subileau, G Merdzhanov, D Ciais, V Collin-Fau, JJ Feige, S Bailly, D Vittet Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation Stem Cell Reports, 2018-12-27;0(0):. 2018-12-27 [PMID: 30595547] (Bioassay, Mouse)	Bioassay	Mouse
B Wang, Y Guo, X Chen, C Zeng, Q Hu, W Yin, W Li, H Xie, B Zhang, X Huang, F Yu Nanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2 Int J Nanomedicine, 2018-11-12;13(0):7395-7408. 2018-11-12 [PMID: 30519022] (Bioassay, Human)	Bioassay	Human
K Oudina, J Paquet, A Moya, E Massouride, M Bensidhoum, N Larochette, M Deschepper, C Pinset, H Petite The paracrine effects of human induced pluripotent stem cells promote bone-like structures via the upregulation of BMP expression in a mouse ectopic model Sci Rep, 2018-11-20;8(1):17106. 2018-11-20 [PMID: 30459360] (Bioassay, Mouse)	Bioassay	Mouse
SY Lee, ED Abel, F Long Glucose metabolism induced by Bmp signaling is essential for murine skeletal development Nat Commun, 2018-11-16;9(1):4831. 2018-11-16 [PMID: 30446646] (Bioassay, Mouse)	Bioassay	Mouse
LS Pane, FG Fulcoli, A Cirino, A Altomonte, R Ferrentino, M Bilio, A Baldini Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer Dis Model Mech, 2018-08-30;11(9):. 2018-08-30 [PMID: 30166330] (Bioassay, Human)	Bioassay	Human
K Sasa, K Yoshimura, A Yamada, D Suzuki, Y Miyamoto, H Imai, K Nagayama, K Maki, M Yamamoto, R Kamijo Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation Sci Rep, 2018-07-12;8(1):10579. 2018-07-12 [PMID: 30002387] (Bioassay, Mouse)	Bioassay	Mouse
K Koefoed, J Skat-Rørda, P Andersen, CB Warzecha, M Pye, TA Andersen, KD Ajbro, E Bendsen, M Narimatsu, F Vilhardt, LB Pedersen, JL Wrana, RH Anderson, K Møllgård, ST Christense, LA Larsen The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development Sci Rep, 2018-06-22;8(1):9542. 2018-06-22 [PMID: 29934521] (Bioassay, Human)	Bioassay	Human
YH Chung, YH Huang, TH Chu, CL Chen, PR Lin, SC Huang, DC Wu, CC Huang, TH Hu, YH Kao, MH Tai BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-?1 signaling Lab. Invest., 2018-05-22;0(0):. 2018-05-22 [PMID: 29789683] (Bioassay, Rat)	Bioassay	Rat
P Jongwattan, M Terajima, PA Miguez, W Querido, H Nagaoka, N Sumida, EG Gurysh, KM Ainslie, N Pleshko, L Perera, M Yamauchi Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function Sci Rep, 2018-05-04;8(1):7022. 2018-05-04 [PMID: 29728612] (Bioassay, Mouse)	Bioassay	Mouse
H Kang, S Jha, Z Deng, N Fratzl-Zel, WA Cabral, A Ivovic, F Meylan, EP Hanson, E Lange, J Katz, P Roschger, K Klaushofer, EW Cowen, RM Siegel, JC Marini, T Bhattachar Somatic activating mutations in MAP2K1 cause melorheostosis Nat Commun, 2018-04-11;9(1):1390. 2018-04-11 [PMID: 29643386] (Bioassay, Human)	Bioassay	Human
P Bozatzi, KS Dingwell, KZ Wu, F Cooper, TD Cummins, LD Hutchinson, J Vogt, NT Wood, TJ Macartney, J Varghese, R Gourlay, DG Campbell, JC Smith, GP Sapkota PAWS1 controls Wnt signalling through association with casein kinase 1? EMBO Rep., 2018-03-07;0(0):. 2018-03-07 [PMID: 29514862] (Bioassay, Human)	Bioassay	Human
DM Burmeister, R Stone, N Wrice, A Laborde, SC Becerra, S Natesan, RJ Christy Delivery of Allogeneic Adipose Stem Cells in Polyethylene Glycol-Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns Stem Cells Transl Med, 2018-02-18;0(0):. 2018-02-18 [PMID: 29457376] (Bioassay, Porcine)	Bioassay	Porcine
M Desancé, R Contentin, L Bertoni, T Gomez-Ledu, T Branly, S Jacquet, JM Betsch, A Batho, F Legendre, F Audigié, P Galéra, M Demoor Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy Int J Mol Sci, 2018-02-10;19(2):. 2018-02-10 [PMID: 29439436] (Bioassay, Equine)	Bioassay	Equine
S Kokabu, V Rosen BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling FEBS Open Bio, 2017-12-16;8(2):168-176. 2017-12-16 [PMID: 29435407] (Bioassay, Mouse)	Bioassay	Mouse
JB Lees-Shepa, M Yamamoto, AA Biswas, SJ Stoessel, SE Nicholas, CA Cogswell, PM Devarakond, MJ Schneider, SM Cummins, NP Legendre, S Yamamoto, V Kaartinen, JW Hunter, DJ Goldhamer Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva Nat Commun, 2018-02-02;9(1):471. 2018-02-02 [PMID: 29396429] (In Vivo, Mouse)	In Vivo	Mouse
WS Fagg, N Liu, MJ Yang, K Cheng, E Chung, JS Kim, G Wu, J Fair Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver Cell Transplant, 2017-12-01;26(12):1868-1877. 2017-12-01 [PMID: 29390880] (Bioassay, Mouse)	Bioassay	Mouse
DW Youngstrom, R Senos, RL Zondervan, JD Brodeur, AR Lints, DR Young, TL Mitchell, ME Moore, MH Myers, WJ Tseng, KM Loomes, KD Hankenson Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects NPJ Regen Med, 2017-12-15;2(0):32. 2017-12-15 [PMID: 29302365] (In Vivo, Mouse)	In Vivo	Mouse
MG Perino, S Yamanaka, DR Riordon, Y Tarasova, KR Boheler Ascorbic acid promotes cardiomyogenesis through SMAD1 signaling in differentiating mouse embryonic stem cells PLoS ONE, 2017-12-12;12(12):e0188569. 2017-12-12 [PMID: 29232368] (Bioassay, Mouse)	Bioassay	Mouse
Y Yu, S Gu, W Li, C Sun, F Chen, M Xiao, L Wang, D Xu, Y Li, C Ding, Z Xia, Y Li, S Ye, P Xu, B Zhao, J Qin, YG Chen, X Lin, XH Feng Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-? signaling Proc. Natl. Acad. Sci. U.S.A., 2017-09-05;0(0):. 2017-09-05 [PMID: 28874583] (Bioassay, Mouse)	Bioassay	Mouse
SJ Bae, HJ Kim, HY Won, YK Min, ES Hwang Acceleration of osteoblast differentiation by a novel osteogenic compound, DMP-PYT, through activation of both the BMP and Wnt pathways Sci Rep, 2017-08-16;7(1):8455. 2017-08-16 [PMID: 28814721] (Bioassay, Mouse)	Bioassay	Mouse
J Fan, J Pi-Anfruns, M Guo, DCS Im, ZK Cui, S Kim, BM Wu, TL Aghaloo, M Lee Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2 Sci Rep, 2017-08-08;7(1):7518. 2017-08-08 [PMID: 28790361] (Bioassay, Human)	Bioassay	Human
C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells J. Biol. Chem., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747434] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
S François, VV Eder, K Belmokhtar, MC Machet, L Douay, NC Gorin, M Benderitte, CA Alain Synergistic effect of human Bone Morphogenic Protein-2 and Mesenchymal Stromal Cells on chronic wounds through hypoxia-inducible factor-1 ? induction Sci Rep, 2017-06-27;7(1):4272. 2017-06-27 [PMID: 28655873] (Bioassay, Rat)	Bioassay	Rat
JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, JE Vallance, NF Shroyer, KL Sinagoga, A Zarzoso-La, JR Hudson, JC Howell, P Chatuvedi, JR Spence, JM Shannon, AM Zorn, MA Helmrath, JM Wells Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling Cell Stem Cell, 2017-06-22;0(0):. 2017-06-22 [PMID: 28648364] (Bioassay, Human)	Bioassay	Human
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J Feng, J Jing, J Li, H Zhao, V Punj, T Zhang, J Xu, Y Chai BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice Development, 2017-06-02;0(0):. 2017-06-02 [PMID: 28576771] (Bioassay, Mouse)	Bioassay	Mouse
YM Lin, J Lee, JFY Lim, M Choolani, JKY Chan, S Reuveny, SKW Oh Critical attributes of human early mesenchymal stromal cell-laden microcarrier constructs for improved chondrogenic differentiation Stem Cell Res Ther, 2017-05-08;8(1):93. 2017-05-08 [PMID: 28482913] (Bioassay, Human)	Bioassay	Human
SJ Bae, YK Min, ES Hwang Potent osteogenic activity of a novel imidazobenzimidazole derivative, IBIP Biochem. Biophys. Res. Commun., 2017-04-15;487(2):409-414. 2017-04-15 [PMID: 28419840] (Bioassay, Mouse)	Bioassay	Mouse
K Breitkopf-, C Meyer, C König, H Gaitantzi, A Addante, M Thomas, E Wiercinska, C Cai, Q Li, F Wan, C Hellerbran, NA Valous, M Hahnel, C Ehlting, JG Bode, S Müller-Boh, U Klingmülle, J Altenöder, I Ilkavets, MJ Goumans, LJ Hawinkels, SJ Lee, M Wieland, C Mogler, MP Ebert, B Herrera, H Augustin, A Sánchez, S Dooley, P Ten Dijke BMP-9 interferes with liver regeneration and promotes liver fibrosis Gut, 2017-03-23;0(0):. 2017-03-23 [PMID: 28336518] (Mouse)		Mouse
DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 2017-04-01;0(0):. 2017-04-01 [PMID: 28270449] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
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ML Stevens, P Chaturvedi, SA Rankin, M Macdonald, S Jagannatha, M Yukawa, A Barski, AM Zorn Genomic integration of Wnt/?-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional program Development, 2017-02-20;0(0):. 2017-02-20 [PMID: 28219948] (Organoid Culture, Xenopus)	Organoid Culture	Xenopus
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SV Hegarty, AM Sullivan, GW O'Keeffe Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth Neurosci. Lett, 2017-02-08;643(0):32-37. 2017-02-08 [PMID: 28188849] (Bioassay, Human)	Bioassay	Human
S Sripathy, V Leko, RL Adrianse, T Loe, EJ Foss, E Dalrymple, U Lao, T Gatbonton-, KT Carter, B Payer, PJ Paddison, WM Grady, JT Lee, MS Bartolomei, A Bedalov Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-? superfamily as a regulator of XIST expression Proc. Natl. Acad. Sci. U.S.A, 2017-01-31;0(0):. 2017-01-31 [PMID: 28143937] (Bioassay, Mouse)	Bioassay	Mouse
Atakan Tevlek Bi-layered constructs of poly(glycerol-sebacate)-?-tricalcium phosphate for bone-soft tissue interface applications Mater Sci Eng C Mater Biol Appl, 2016-11-27;72(0):316-324. 2016-11-27 [PMID: 28024592] (Bioassay, Mouse)	Bioassay	Mouse
Yan-Ting Wu Bone morphogenetic protein 2 regulates cell-cell communication by down-regulating connexin43 expression in luteinized human granulosa cells Mol. Hum. Reprod, 2017-03-01;0(0):. 2017-03-01 [PMID: 27986931] (Bioassay, Human)	Bioassay	Human
Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication PLoS ONE, 2016-12-15;11(12):e0168334. 2016-12-15 [PMID: 27977771] (Bioassay, Human)	Bioassay	Human
G B de Souza Bovine ovarian stem cells differentiate into germ cells and oocyte-like structures after culture in vitro Reprod. Domest. Anim, 2016-12-07;0(0):. 2016-12-07 [PMID: 27925309] (Bioassay, Bovine)	Bioassay	Bovine
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Katsuhiro Hiranuma, Atsushi Yamada, Tamaki Kurosawa, Ryo Aizawa, Dai Suzuki, Yoshiro Saito, Ryo Nagahama, Mikiko Ikehata, Masayuki Tsukasaki, Naoko Morimura, Daichi Chikazu, Koutaro Maki, Tatsuo Shirota, Masamichi Takami, Matsuo Yamamoto, Takehiko Iijima, Ryutaro Kamijo Expression of nephronectin is enhanced by 1?,25-dihydroxyvitamin D3. FEBS Open Bio, 2016-07-13;0(0):2211-5463. 2016-07-13 [PMID: 27642554] (Bioassay, Mouse)	Bioassay	Mouse
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Malhotra , Rajeev, Burke , Megan F, Martyn , Trejeeve, Shakartzi , Hannah R, Thayer , Timothy, O'Rourke , Caitlin, Li , Pingchen, Derwall , Matthias, Spagnolli , Ester, Kolodziej , Starsha, Hoeft , Konrad, Mayeur , Claire, Jiramongkolchai , Pawina, Kumar , Ravindra, Buys , Emmanuel, Yu , Paul B, Bloch , Kenneth, Bloch , Donald B Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency. PLoS ONE, 2015-01-20;10(1):e0117098. 2015-01-20 [PMID: 25603410] (Bioassay, Mouse)	Bioassay	Mouse
Prewitt A, Ghose S, Frump A, Datta A, Austin E, Kenworthy A, de Caestecker M Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension. J Biol Chem, 2014-11-19;290(2):960-71. 2014-11-19 [PMID: 25411245] (Bioassay, Mouse)	Bioassay	Mouse
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Alberton P, Dex S, Popov C, Shukunami C, Schieker M, Docheva D Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells. Stem Cells Dev, 2014-12-10;24(5):597-609. 2014-12-10 [PMID: 25351164] (Bioassay, Mouse)	Bioassay	Mouse
Yang X, Trehan S, Guan Y, Sun C, Moore D, Jayasuriya C, Chen Q Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist. J Biol Chem, 2014-10-20;289(50):34768-79. 2014-10-20 [PMID: 25331953] (Bioassay, Chicken, Mouse)	Bioassay	Chicken, Mouse
Park J, Jang S, Park D, Lim N, Deng C, Kim D, Green J, Kim H Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. Mol Cancer Res, 2014-04-30;12(8):1088-99. 2014-04-30 [PMID: 24784840] (Bioassay, Mouse)	Bioassay	Mouse
Shen , Jinhui, Nair , Ashwin, Saxena , Ramesh, Zhang , Cheng Ch, Borrelli , Joseph J, Tang , Liping Tissue engineering bone using autologous progenitor cells in the peritoneum. PLoS ONE, 2014-03-28;9(3):e93514. 2014-03-28 [PMID: 24681529] (Bioassay, Mouse)	Bioassay	Mouse
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Dussiot M, Maciel T, Fricot A, Chartier C, Negre O, Veiga J, Grapton D, Paubelle E, Payen E, Beuzard Y, Leboulch P, Ribeil J, Arlet J, Cote F, Courtois G, Ginzburg Y, Daniel T, Chopra R, Sung V, Hermine O, Moura I An activin receptor IIA ligand trap corrects ineffective erythropoiesis in beta-thalassemia. Nat Med, 2014-03-23;20(4):398-407. 2014-03-23 [PMID: 24658077] (Bioassay, Mouse)	Bioassay	Mouse
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Heinonen A, Rahman M, Dogbevia G, Jakobi H, Wolfl S, Sprengel R, Schwaninger M Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7. BMC Neurosci, 2014-03-11;15(0):38. 2014-03-11 [PMID: 24618040] (Bioassay, Human)	Bioassay	Human
Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, Apuzzo T, Sperduti I, Volpe S, Cocorullo G, Gulotta G, Dieli F, De Maria R, Stassi G CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell, 2014-03-06;14(3):342-56. 2014-03-06 [PMID: 24607406] (Bioassay, Human)	Bioassay	Human
Abdel Aziz M, Wassef M, Ahmed H, Rashed L, Mahfouz S, Aly M, Hussein R, Abdelaziz M The role of bone marrow derived-mesenchymal stem cells in attenuation of kidney function in rats with diabetic nephropathy. Diabetol Metab Syndr, 2014-03-09;6(1):34. 2014-03-09 [PMID: 24606996] (Bioassay, Mouse)	Bioassay	Mouse
Gao X, Cao Y, Staloch D, Gonzales M, Aronson J, Chao C, Hellmich M, Ko T Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis. PLoS ONE, 2014-02-21;9(2):e89114. 2014-02-21 [PMID: 24586530] (Bioassay, Mouse)	Bioassay	Mouse
Wolf S, Hagl B, Kappler R Identification of BMP2 as an epigenetically silenced growth inhibitor in rhabdomyosarcoma. Int J Oncol, 2014-02-27;44(5):1727-35. 2014-02-27 [PMID: 24585058] (Bioassay, Human)	Bioassay	Human
Suresh Babu S, Valdez Y, Xu A, O'Byrne A, Calvo F, Lei V, Conway E TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer, 2014-02-20;14(0):113. 2014-02-20 [PMID: 24555435] (Bioassay, Mouse)	Bioassay	Mouse
Ratnayake M, Ploger F, Santibanez-Koref M, Loughlin J Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5. PLoS ONE, 2014-01-21;9(1):e86590. 2014-01-21 [PMID: 24466161] (Bioassay, Human)	Bioassay	Human
Hang , Qinglei, Zhou , Ying, Hou , Sicong, Zhang , Dongmei, Yang , Xiaojing, Chen , Jianping, Ben , Zhiyun, Cheng , Chun, Shen , Aiguo Asparagine-linked glycosylation of bone morphogenetic protein-2 is required for secretion and osteoblast differentiation. Glycobiology, 2013-12-12;24(3):292-304. 2013-12-12 [PMID: 24336949] (Bioassay, Hamster)	Bioassay	Hamster
Bizen N, Inoue T, Shimizu T, Tabu K, Kagawa T, Taga T A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal. Stem Cells, 2014-06-01;32(6):1602-15. 2014-06-01 [PMID: 24302516] (Bioassay, Mouse)	Bioassay	Mouse
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Gao L, Sheu T, Dong Y, Hoak D, Zuscik M, Schwarz E, Hilton M, O'Keefe R, Jonason J TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci, 2013-10-21;126(0):5704-13. 2013-10-21 [PMID: 24144697] (Bioassay, Mouse)	Bioassay	Mouse
Kawamoto T, Kobayashi Y, Nakajima H, Yamagishi Y Generation of robust vascular networks from cardiovascular blast populations derived from human induced pluripotent stem cells in vivo and ex vivo organ culture system. Biochem Biophys Res Commun, 2013-10-16;441(1):180-5. 2013-10-16 [PMID: 24140407] (Bioassay, Mouse)	Bioassay	Mouse
Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, Ffrench M, Salesse S, Nicolini F, Maguer-Satta V Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression. Blood, 2013-10-07;122(23):3767-77. 2013-10-07 [PMID: 24100446] (Bioassay, Human)	Bioassay	Human
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Talavera-Adame , Dodanim, Gupta , Ankur, Kurtovic , Silvia, Chaiboonma , Kira L, Arumugaswami , Vaithili, Dafoe , Donald C Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation. Stem Cells Dev, 2013-09-24;22(24):3252-60. 2013-09-24 [PMID: 23924071] (Bioassay, Mouse)	Bioassay	Mouse
Gadi , Jogeswar, Jung , Seung-Hy, Lee , Min-Jung, Jami , Ajita, Ruthala , Kalyani, Kim , Kyoung-M, Cho , Nam-Hoon, Jung , Han-Sung, Kim , Cheol-He, Lim , Sung-Kil The transcription factor protein Sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors. J Biol Chem, 2013-07-25;288(35):25400-13. 2013-07-25 [PMID: 23888050] (Bioassay, Mouse)	Bioassay	Mouse
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Wang , Yidong, Wu , Bingruo, Chamberlain , Alyssa A, Lui , Wendy, Koirala , Pratisth, Susztak , Katalin, Klein , Diana, Taylor , Verdon, Zhou , Bin Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS ONE, 2013-04-01;8(4):e60244. 2013-04-01 [PMID: 23560082] (Bioassay, Mouse)	Bioassay	Mouse
Li S, Meyer N, Quarto N, Longaker M Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts. PLoS ONE, 2013-03-25;8(3):e58610. 2013-03-25 [PMID: 23536803] (Bioassay, Mouse)	Bioassay	Mouse
Glister C, Satchell L, Bathgate R, Wade J, Dai Y, Ivell R, Anand-Ivell R, Rodgers R, Knight P Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A, 2013-03-25;110(15):E1426-35. 2013-03-25 [PMID: 23530236] (Bioassay, Bovine)	Bioassay	Bovine
Yamamoto-Shiraishi Y, Kuroiwa A Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor. 2013-03-13;0(0):. 2013-03-13 [PMID: 23499659] (In Vivo, Mouse)	In Vivo	Mouse
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Chen , Jiekai, Liu , He, Liu , Jing, Qi , Jing, Wei , Bei, Yang , Jiaqi, Liang , Hanquan, Chen , You, Chen , Jing, Wu , Yaran, Guo , Lin, Zhu , Jieying, Zhao , Xiangjie, Peng , Tianran, Zhang , Yixin, Chen , Shen, Li , Xuejia, Li , Dongwei, Wang , Tao, Pei , Duanqing H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2012-12-02;45(1):34-42. 2012-12-02 [PMID: 23202127] (Bioassay, Mouse)	Bioassay	Mouse
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Geens M, Sermon KD Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells. J. Assist. Reprod. Genet., 2011-02-12;0(0):. 2011-02-12 [PMID: 21318592] (Bioassay, Human)	Bioassay	Human
Dalfino G, Simone S, Porreca S, Cosola C, Balestra C, Manno C, Schena FP, Grandaliano G, Pertosa G Bone morphogenetic protein-2 may represent the molecular link between oxidative stress and vascular stiffness in chronic kidney disease. Atherosclerosis, 2010-04-29;211(2):418-23. 2010-04-29 [PMID: 20537331] (Bioassay, Human)	Bioassay	Human
Haupt LM, Murali S, Mun FK, Teplyuk N, Mei LF, Stein GS, van Wijnen AJ, Nurcombe V, Cool SM The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis. J. Cell. Physiol., 2009-09-01;220(3):780-91. 2009-09-01 [PMID: 19479939] (Bioassay, Mouse)	Bioassay	Mouse
Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood, 2009-05-04;114(1):181-6. 2009-05-04 [PMID: 19414861] (Bioassay, Human)	Bioassay	Human
Little SC, Mullins MC Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat. Cell Biol., 2009-04-19;11(5):637-43. 2009-04-19 [PMID: 19377468] (Bioassay, Zebrafish)	Bioassay	Zebrafish
Shafer SL, Towler DA Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element. J. Mol. Cell. Cardiol., 2009-01-21;46(5):621-35. 2009-01-21 [PMID: 19344627] (Bioassay, Mouse)	Bioassay	Mouse
Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, Iwakura Y, Suda T, Matsuo K Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J. Biol. Chem., 2009-03-19;284(21):14637-44. 2009-03-19 [PMID: 19299512] (Bioassay, Mouse)	Bioassay	Mouse
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature, 2008-08-21;454(7207):1000-4. 2008-08-21 [PMID: 18719589] (Bioassay, Mouse)	Bioassay	Mouse
Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood, 2008-07-29;112(8):3154-63. 2008-07-29 [PMID: 18664625] (Bioassay, Human)	Bioassay	Human
Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol., 2008-07-02;381(4):1025-39. 2008-07-02 [PMID: 18621057] (ELISA (Capture), Surface Plasmon Resonance, Human)	ELISA (Capture), Surface Plasmon Resonance	Human
Kane R, Godson C, O'Brien C Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol. Vis., 2008-06-20;14(0):1138-48. 2008-06-20 [PMID: 18587495] (Bioassay, Human)	Bioassay	Human
Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2008-06-05;2(6):602-12. 2008-06-05 [PMID: 18522853] (Bioassay, Human)	Bioassay	Human
Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J. Biol. Chem., 2008-03-13;283(20):13874-88. 2008-03-13 [PMID: 18339631] (Binding Assay, Surface Plasmon Resonance, Human)	Binding Assay, Surface Plasmon Resonance	Human
Pi X, Ren R, Kelley R, Zhang C, Moser M, Bohil AB, Divito M, Cheney RE, Patterson C Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors. J. Cell Biol., 2007-12-24;179(7):1569-82. 2007-12-24 [PMID: 18158328] (Bioassay, Mouse)	Bioassay	Mouse
Hocking JC, Hehr CL, Chang RY, Johnston J, McFarlane S TGFbeta ligands promote the initiation of retinal ganglion cell dendrites in vitro and in vivo. Mol. Cell. Neurosci., 2007-10-05;37(2):247-60. 2007-10-05 [PMID: 17997109] (Bioassay, Xenopus)	Bioassay	Xenopus
Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol., 2008-01-01;214(1):85-95. 2008-01-01 [PMID: 17992660] (Bioassay, Human)	Bioassay	Human
Wen Z, Han L, Bamburg JR, Shim S, Ming GL, Zheng JQ BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J. Cell Biol., 2007-07-02;178(1):107-19. 2007-07-02 [PMID: 17606869] (Bioassay, Xenopus)	Bioassay	Xenopus
Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature, 2007-06-27;448(7150):196-9. 2007-06-27 [PMID: 17597760] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, Tada N Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. J. Immunol., 2007-07-01;179(1):639-46. 2007-07-01 [PMID: 17579086] (Bioassay, Mouse)	Bioassay	Mouse
Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood, 2007-05-31;110(6):2182-9. 2007-05-31 [PMID: 17540841] (Bioassay, Mouse)	Bioassay	Mouse
Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G Dickkopf-1 is a master regulator of joint remodeling. Nat. Med., 2007-01-21;13(2):156-63. 2007-01-21 [PMID: 17237793] (Bioassay, Mouse)	Bioassay	Mouse
Ungefroren H, Schniewind B, Groth S, Chen WB, Muerkoster SS, Kalthoff H, Fandrich F Antitumor activity of ALK1 in pancreatic carcinoma cells. Int. J. Cancer, 2007-04-15;120(8):1641-51. 2007-04-15 [PMID: 17230504] (Bioassay, Human)	Bioassay	Human
Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood, 2007-01-16;109(9):3706-12. 2007-01-16 [PMID: 17227831] (Bioassay, Mouse)	Bioassay	Mouse
Gossrau G, Thiele J, Konang R, Schmandt T, Brustle O Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells. Stem Cells, 2007-01-11;25(4):939-49. 2007-01-11 [PMID: 17218404] (Bioassay, Mouse)	Bioassay	Mouse
Yao Y, Zebboudj AF, Torres A, Shao E, Bostrom K Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells. Cardiovasc. Res., 2006-09-27;74(2):279-89. 2006-09-27 [PMID: 17074310] (Bioassay, Bovine, Human)	Bioassay	Bovine, Human
Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium. Am. J. Physiol. Heart Circ. Physiol., 2006-10-20;292(2):H1095-104. 2006-10-20 [PMID: 17056665] (Bioassay, Canine, Human)	Bioassay	Canine, Human
Bonafede A, Kohler T, Rodriguez-Niedenfuhr M, Brand-Saberi B BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Dev. Biol., 2006-06-15;299(2):330-44. 2006-06-15 [PMID: 17005177] (In Vivo, Chicken)	In Vivo	Chicken
Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Res. Ther., 2006-01-01;8(5):R146. 2006-01-01 [PMID: 16945157] (Bioassay, Mouse)	Bioassay	Mouse
Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development, 2006-08-30;133(19):3787-96. 2006-08-30 [PMID: 16943279] (Bioassay, Mouse)	Bioassay	Mouse
Liu HW, Chen CH, Tsai CL, Hsiue GH Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation. Bone, 2006-06-16;39(4):825-36. 2006-06-16 [PMID: 16782421] (In Vivo, Rabbit)	In Vivo	Rabbit
Schlueter J, Manner J, Brand T BMP is an important regulator of proepicardial identity in the chick embryo. Dev. Biol., 2006-04-01;295(2):546-58. 2006-04-01 [PMID: 16677627] (Bioassay, Chicken)	Bioassay	Chicken
Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-04-27;295(2):473-85. 2006-04-27 [PMID: 16643884] (Bioassay, Rat)	Bioassay	Rat
Hong SJ, Kim CS, Han DK, Cho IH, Jung UW, Choi SH, Kim CK, Cho KS The effect of a fibrin-fibronectin/beta-tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects. Biomaterials, 2006-03-29;27(20):3810-6. 2006-03-29 [PMID: 16574220] (In Vivo, Rat)	In Vivo	Rat
Blair DG, Plisov S, Vasiliev G, Perantoni AO, Athanasiou M, Wu JY, Oppenheim JJ Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. J. Immunol., 2004-11-15;173(10):5914-7. 2004-11-15 [PMID: 15528323] (Bioassay, Human)	Bioassay	Human
Knosp WM, Scott V, Bachinger HP, Stadler HS HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis. Development, 2004-09-01;131(18):4581-92. 2004-09-01 [PMID: 15342482] (In Vivo, Mouse)	In Vivo	Mouse
Binnerts ME, Wen X, Cante-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. Biochem. Biophys. Res. Commun., 2004-03-05;315(2):272-80. 2004-03-05 [PMID: 14766204] (Bioassay, Mouse)	Bioassay	Mouse
Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol. Cell. Biol., 2003-08-01;23(16):5664-79. 2003-08-01 [PMID: 12897139] (Bioassay, Mouse)	Bioassay	Mouse
Lee YM, Nam SH, Seol YJ, Kim TI, Lee SJ, Ku Y, Rhyu IC, Chung CP, Han SB, Choi SM Enhanced bone augmentation by controlled release of recombinant human bone morphogenetic protein-2 from bioabsorbable membranes. J. Periodontol., 2003-06-01;74(6):865-72. 2003-06-01 [PMID: 12886998] (Bioassay, Rabbit)	Bioassay	Rabbit
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Array 355-BM/CF

• BMP-2 Antibodies
• BMP-2 Antibody Pair
• BMP-2 ELISA Kit
• BMP-2 Lysate
• BMP-2 Proteins
• BMP-2 Proteins and Enzymes
• BMP-2 ELISAs