Recombinant Human BMP-10 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BMP-10, along with BMP-9, GDF-5, -6, and -7, belongs to a subgroup of TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors (1-3). Proteolytic removal of the propeptide from the 60 kDa proprotein yields a 12 kDa mature BMP-10 which forms disulfide-linked
non-glycosylated homodimers (4, 5). Mature human BMP-10 shares 98% amino acid sequence identity with mouse and rat BMP-10 and 49% - 63% with human BMP-9, GDF-5, -6, and -7. BMP-10 is critical for the proper development of the heart but is not expressed until after cardiac patterning or looping are completed (6-8). BMP-10 production appears at the onset of trabeculation and chamber formation and is restricted to the right atrium in the adult heart (6-8). Homozygous BMP-10 knockout mice die in utero due to arrested cardiac development (7). BMP-10 is required for the expression of the cardiogenic transcription factors NKX2.5 and MEF2C in developing myocardium and the growth of embryonic cardiomyocytes (7, 10). NKX2.5 itself negatively regulates BMP-10 expression in cardiac myocytes (10). Multiple human congenital heart defects result from mutations in NKX2.5 and require BMP-10 expression (10). In mice, genetic knockout of ErbB leads to a similar phenotype but appears not to involve BMP-10, and knockout of the calcium channel subunit FKBP12 induces BMP-10 over-expression (7). BMP-10 in the postnatal heart promotes increased cardiomyocyte and heart size (8). BMP-10 has been shown to signal through ALK-1, BMPR-IA, BMPR-IB, and BMPR-II in transfectants and non-cardiac cell lines (4, 5). A functional BMP-10 receptor in the heart has not yet been identified, although deletion of BMPR-IA causes similar cardiac morphogenetic abnormalities (11). In dermal endothelial cells, BMP-10 induces migration, proliferation, and gene expression typically associated with ALK-1 (5).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Binding Assay, Bioassay, Cell Culture, Surface Plasmon Resonance, Western Blot.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using 2926-BP	Applications	Species
Cheng, YW;Anzell, AR;Morosky, SA;Schwartze, TA;Hinck, CS;Hinck, AP;Roman, BL;Davidson, LA; Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells Cells 2024-02-05 [PMID: 38334677] (Bioassay, Human)	Bioassay	Human
C Ivaldo, M Passalacqu, AL Furfaro, C d'Abramo, S Ruiz, PK Chatterjee, CN Metz, M Nitti, P Marambaud Oxidative stress-induced MMP- and gamma-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10 Scientific Reports, 2023-01-11;13(1):597. 2023-01-11 [PMID: 36631513] (Cell Culture, Human)	Cell Culture	Human
Z Shonibare, M Monavarian, K O'Connell, D Altomare, A Shelton, S Mehta, R Jaskula-Sz, R Phaeton, MD Starr, R Whitaker, A Berchuck, AB Nixon, RC Arend, NY Lee, CR Miller, N Hempel, K Mythreye Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer Oncogene, 2022-07-26;40(4):111066. 2022-07-26 [PMID: 35905726] (Bioassay, Human)	Bioassay	Human
J Guo, B Liu, M Thorikay, M Yu, X Li, Z Tong, RM Salmon, RJ Read, P Ten Dijke, NW Morrell, W Li Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10 Nature Communications, 2022-05-03;13(1):2395. 2022-05-03 [PMID: 35504921] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
R Kumar, AV Grinberg, H Li, TH Kuo, D Sako, L Krishnan, K Liharska, J Li, R Grenha, MC Maguire, SD Briscoe, RS Pearsall, BR Herrin, RNVS Suragani, R Castonguay Functionally diverse heteromeric traps for ligands of the transforming growth factor-beta superfamily Scientific Reports, 2021-09-15;11(1):18341. 2021-09-15 [PMID: 34526551] (Bioassay, Human)	Bioassay	Human
M Subileau, G Merdzhanov, D Ciais, V Collin-Fau, JJ Feige, S Bailly, D Vittet Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation Stem Cell Reports, 2018-12-27;0(0):. 2018-12-27 [PMID: 30595547] (Bioassay, Mouse)	Bioassay	Mouse
E Tillet, M Ouarné, A Desroches-, C Mallet, M Subileau, R Didier, A Lioutsko, G Belthier, JJ Feige, S Bailly A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma J. Biol. Chem., 2018-05-22;0(0):. 2018-05-22 [PMID: 29789425] (Western Blot)	Western Blot
CG Mitrofan, SL Appleby, GB Nash, Z Mallat, ER Chilvers, PD Upton, NW Morrell Bone morphogenetic protein (BMP) 9 and BMP10 enhance tumor necrosis factor-?-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2 J. Biol. Chem., 2017-06-23;0(0):. 2017-06-23 [PMID: 28646109] (Bioassay, Human)	Bioassay	Human
Y Tachida, N Izumi, T Sakurai, H Kobayashi Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells Biol Open, 2017-03-15;6(3):370-380. 2017-03-15 [PMID: 28298363] (Bioassay, Human)	Bioassay	Human
Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A, 2015-06-08;112(25):E3207-15. 2015-06-08 [PMID: 26056270] (Bioassay, Human)	Bioassay	Human
Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, Ricci-Vitiani L, D'Alessandris Q, Morgante L, Giannetti S, Larocca L, Todaro M, Benfante A, Colorito M, Stassi G, De Maria R, Rowlinson S, Stancato L A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS ONE, 2015-04-28;10(4):e0125697. 2015-04-28 [PMID: 25919028] (Bioassay, Human)	Bioassay	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood, 2012-05-07;119(25):6162-71. 2012-05-07 [PMID: 22566602] (Bioassay, Human)	Bioassay	Human
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Bioassay, Surface Plasmon Resonance, Human, Mouse)	Bioassay, Surface Plasmon Resonance	Human, Mouse
Herrera B, Inman GJ A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol., 2009-03-19;10(0):20. 2009-03-19 [PMID: 19298647] (Bioassay, Mouse)	Bioassay	Mouse
Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J. Biol. Chem., 2008-03-13;283(20):13874-88. 2008-03-13 [PMID: 18339631] (Binding Assay, Surface Plasmon Resonance, Human)	Binding Assay, Surface Plasmon Resonance	Human
Show All 16 Publications. Collapse Publications.

Array 2926-BP

• BMP-10 Antibodies
• BMP-10 ELISA Kit
• BMP-10 Lysate
• BMP-10 Proteins and Enzymes
• BMP-10 ELISA