Western Blot: PSMB5 Antibody [NBP2-13820] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: Hep-G2
Immunocytochemistry/ Immunofluorescence: PSMB5 Antibody [NBP2-13820] - Staining of human cell line PC-3 shows localization to nucleoplasm. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: PSMB5 Antibody [NBP2-13820] - Staining of human cerebellum shows strong nuclear positivity in cells in granular layer.
Immunohistochemistry-Paraffin: PSMB5 Antibody [NBP2-13820] - Staining of human testis shows strong nuclear positivity in a subset of cells in seminiferous ducts.
Immunohistochemistry-Paraffin: PSMB5 Antibody [NBP2-13820] - Staining of human kidney shows strong nuclear positivity in cells in glomeruli.
Immunohistochemistry-Paraffin: PSMB5 Antibody [NBP2-13820] - Staining of human skin shows no positivity in squamous epithelial cells as expected.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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