LMP7/PSMB8 Antibody (1B3)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, IHC-P.

Showing Publications 1 - 3 of 3.

Publications using H00005696-M01	Applications	Species
Stelloo E, Versluis MA, Nijman HW et al. Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer. Oncotarget. 2016-06-28 [PMID: 27213585] (IF/IHC, Human)	IF/IHC	Human
Nijholt DA, de Graaf TR, van Haastert ES et al. Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease. Cell Death Differ 2011-01-21 [PMID: 21252911]
Leffers N, Gooden MJ, Mokhova AA et al. Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer. Gynecol Oncol 2009-05-01 [PMID: 19243813] (IHC-P, Human)	IHC-P	Human

Array H00005696-M01

• LMP7/PSMB8 Antibodies
• LMP7/PSMB8 Lysates
• LMP7/PSMB8 Proteins