LMP7/PSMB8 Products

Description

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Bioinformatics

Entrez	16913 Mouse 24968 Rat 5696 Human
Uniprot	AAH01114 Human NM_004159 Human NM_148919 Human NP_004150 Human NP_004150.1 Human P28062 Human
Product By Gene ID	5696
Alternate Names	beta5i D6S216E EC 3.4.25.1 LMP7MGC1491 Low molecular mass protein 7 low molecular weight protein 7 Macropain subunit C13 Multicatalytic endopeptidase complex subunit C13 protease component C13 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctionalpeptidase 7) proteasome catalytic subunit 3i Proteasome component C13 proteasome subunit beta 5i proteasome subunit beta type-8 Proteasome subunit beta-5i proteasome subunit Y2 proteasome-related gene 7 PSMB5iD6S216 Really interesting new gene 10 protein RING10proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctionalprotease 7) Y2

Research Areas for LMP7/PSMB8

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Stem Cell Markers