PA28 Activator alpha Subunit/PSME1 Antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP1-83121	Applications	Species
Mamrosh JL, Sherman DJ, Cohen JR et al. Quantitative measurement of the requirement of diverse protein degradation pathways in MHC class I peptide presentation Science advances 2023-06-23 [PMID: 37352349] (WB, Human)	WB	Human
Misiewicz-Krzeminska, I, de Ramon, C Et al. Quantitative expression of Ikaros, IRF4, and PSMD10 proteins predicts survival in VRD-treated patients with multiple myeloma. Blood Adv 2020-12-08 [PMID: 33284947] (WB, Human)	WB	Human
Artyomov MN, Munk A, Gorvel L et al. Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells J. Exp. Med. 2015-04-27 [PMID: 25918340] (IF/IHC, Human)	IF/IHC	Human
Kamper P, Ludvigsen M, Bendix K et al. Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma. Blood 2011-06-01 [PMID: 21505194]

Array NBP1-83121

• PA28 Activator alpha Subunit/PSME1 Antibodies
• PA28 Activator alpha Subunit/PSME1 Lysate
• PA28 Activator alpha Subunit/PSME1 Protein
• PA28 Activator alpha Subunit/PSME1 Proteins and Enzyme