S5a/Angiocidin Antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: KD, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-19952	Applications	Species
Osei-Amponsa V, Sridharan V, Tandon M et al. Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity Mol. Cell. Biol. 2020-07-06 [PMID: 32631902]
Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10 Buel GR, Chen X, Chari R et al. Nat Commun [PMID: 32157086] (KD, WB, Human)	KD, WB	Human

Array NBP2-19952

• S5a/Angiocidin Antibodies
• S5a/Angiocidin Lysate
• S5a/Angiocidin Proteins