Please differentiate to me between PPAR and PGC clearly. I am confused with the difference between these two

Name: PGC1 alpha [p Ser571] Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF6650
Rating: 4 (1 reviews)

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Accepted Answer

Thank you very much for contacting Novus Biologicals technical support team and sharing your query on the differences between PGC-1 alpha and PPAR. These are two different proteins encoded by their respective genes and serves different functions. PGC-1 alpha (PGC1A or PPAR gamma coactivator 1-alpha) is a transcriptional co-activator for steroid receptors and nuclear receptors, and it regulates diverse aspects of cellular physiology. It up-regulates the transcriptional activity of PPAR-gamma /thyroid hormone receptor on the uncoupling protein promoter; regulates the key mitochondrial genes involved in adaptive thermogenesis; implicates in the metabolic reprogramming in response to nutrients availability through the coordination of the expression of a wide array of genes involved in the regulation of glucose and fatty acid metabolism. Among our PGC-1 alpha antibodies, NBP1-04676 is our best selling product with nice customer feedback and citations in at least 13 research publications. PPAR (PPAR alpha) on the other hand is a ligand-activated transcription factor which gets activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine, and oleylethanolamide (a naturally occurring lipid that regulates satiety), and acts as a key regulator of lipid metabolism. It also acts as a receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. It regulates the peroxisomal beta-oxidation pathway of fatty acids, and also functions as transcription activator for the ACOX1 and P450 genes. We have a variety of PPAR alpha antibodies. I hope you will find this information helpful but please let me know if I can support you with anything else from my end. Thank you very much for choosing Novus Biologicals as your quality reagent supplier and we wish you the best with your research projects.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB
Clonality	Polyclonal
Host	Rabbit
Conjugate	Unconjugated

Catalog# & Formulation	Size	Price
Carrier Free AF6650-SP

Immunogen	Phosphopeptide containing the human PGC1 alpha S571 site.
Modification	p Ser571
Specificity	Detects human PGC1 alpha when phosphorylated at S571 in Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Rabbit
Gene	PPARGC1A
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Sterile PBS to a final concentration of 0.2 mg/mL.

PGC1 alpha [p Ser571] Antibody [Unconjugated]

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Publications for PGC1 alpha Antibody (AF6650)(13)

Review for PGC1 alpha Antibody (AF6650) (1) 41

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Publications using AF6650	Applications	Species
Guo Z, Wang M, Ying X et al. Caloric restriction increases the resistance of aged heart to myocardial ischemia/reperfusion injury via modulating AMPK-SIRT1-PGC1a energy metabolism pathway Scientific reports 2023-02-04 [PMID: 36739302]
S Ogden, K Carys, I Ahmed, J Bruce, AD Sharrocks Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition Oncogene, 2022-09-24;0(0):. 9/24/2022 [PMID: 36153371]
X Li, Z Zhuge, LRRA Carvalho, VA Braga, RB Lucena, S Li, TA Schiffer, H Han, E Weitzberg, JO Lundberg, M Carlström Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1alpha pathway Redox Biology, 2022-02-17;51(0):102266. 2022-02-17 [PMID: 35217293] (Western Blot, Human)	Western Blot	Human
Kiyoharu J. Miyagishima, Ruchi Sharma, Malika Nimmagadda, Katharina Clore-Gronenborn, Zoya Qureshy, Davide Ortolan et al. AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration Communications Biology 2021-12-09 [PMID: 34887495]
M van der En, RLC Plas, M van Dijk, JT Dwarkasing, F van Gemerd, A Sarokhani, HJM Swarts, EM van Schoth, S Grefte, RF Witkamp, K van Norren Effects of whole-body vibration training in a cachectic C26 mouse model Scientific Reports, 2021-11-03;11(1):21563. 2021-11-03 [PMID: 34732809] (Western Blot, Mouse)	Western Blot	Mouse
Jennifer L. Larson‐Casey, Linlin Gu, Dana Davis, Guo‐Qiang Cai, Qiang Ding, Chao He et al. Post‐translational regulation of PGC‐1 alpha modulates fibrotic repair The FASEB Journal 2021-06-01 [PMID: 34038004]
Bucher M, Montaniel KRC, Myatt L et al. Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers Journal of Developmental Origins of Health and Disease 2021-10-01 [PMID: 33185172]
Piers TM, Cosker K, Mallach A et al. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia FASEB J. 2/1/2020 [PMID: 31907987]
J Miao, J Liu, J Niu, Y Zhang, W Shen, C Luo, Y Liu, C Li, H Li, P Yang, Y Liu, FF Hou, L Zhou Wnt/?-catenin/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction Aging Cell, 2019-07-18;0(0):e13004. 2019-07-18 [PMID: 31318148] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
HY Jeong, JM Kang, HH Jun, DJ Kim, SH Park, MJ Sung, JH Heo, DH Yang, SH Lee, SY Lee Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy Sci Rep, 2018-06-08;8(1):8774. 2018-06-08 [PMID: 29884802] (Western Blot, Human)	Western Blot	Human
MP Sajan, MC Lee, F Foufelle, J Sajan, C Cleland, RV Farese Coordinated regulation of hepatic FoxO1, PGC-1? and SREBP-1c facilitates insulin action and resistance Cell. Signal., 2017-12-18;43(0):62-70. 2017-12-18 [PMID: 29269047] (Western Blot, Mouse)	Western Blot	Mouse
K Bernard, NJ Logsdon, V Miguel, GA Benavides, J Zhang, AB Carter, VM Darley-Usm, VJ Thannickal NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway J. Biol. Chem, 2017-01-03;292(7):3029-3038. 2017-01-03 [PMID: 28049732] (Western Blot, Human)	Western Blot	Human
Bernard K, Logsdon N, Ravi S, Xie N, Persons B, Rangarajan S, Zmijewski J, Mitra K, Liu G, Darley-Usmar V, Thannickal V Metabolic Reprogramming Is Required for Myofibroblast Contractility and Differentiation. J Biol Chem, 2015-08-28;290(42):25427-38. 2015-08-28 [PMID: 26318453] (Western Blot, Human)	Western Blot	Human
Show All 13 Publications. Collapse Publications.

	Verified Customer 07/14/2016
Application:	WB
Species:	Mouse