ERR alpha/NR3B1 Antibody - BSA Free

Nuclear receptors are essential in embryonic development as well as for the regulation of adult physiological functions, and estrogen related receptor alpha (ERR-alpha) is one such receptors expressed in several tissues requiring high energy demand, including heart, skeletal muscle and brain. ERR-alpha binds to ERRE (ERR-alpha response element) containing a single consensus half-site, 5'-TNAAGGTCA-3'; to MCAD response element NRRE-1 for regulating MCAD promoter, and it also regulates lactoferrin gene promoter. ERR-alpha is an orphan nuclear hormone receptor capable of regulating transcription of genes involved in multiple cellular/physiological processes such as regulation of energy metabolism wherein it is co-activated by PPAR gamma and PGC-1 alpha to regulate several genes required for mitochondrial function. ERR-alpha regulates estrogen signaling and fatty acid oxidation/adaptative bioenergetic response, and is involved in cartilage/bone formation, macrophage activation and carcinogenesis. High ERR-alpha expression levels coupled with poor prognosis have been observed in various malignancies including colon, endometrium, ovary, prostate and breast cancers, and adrenocortical carcinoma.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 7 of 7.

Publications using NBP1-47254	Applications	Species
Kim M, Kim J, Moon S et al. Korean Red Ginseng Improves Astrocytic Mitochondrial Function by Upregulating HO-1-Mediated AMPK alpha-PGC-1 alpha-ERR alpha Circuit after Traumatic Brain Injury International journal of molecular sciences 2021-12-03 [PMID: 34884886] (WB, Human, Mouse)	WB	Human, Mouse
Wang L, Yang M, Jin H PI3K/AKT phosphorylation activates ERR alpha by upregulating PGC‑1 alpha and PGC‑1 beta in gallbladder cancer Molecular medicine reports 2021-08-01 [PMID: 34184087] (WB)	WB
Hauck L, Stanley-Hasnain S, Fung A et al. Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death PLoS ONE 2017-12-21 [PMID: 29267372] (WB, Mouse)	WB	Mouse
Mak TW, Hauck L, Grothe D, Billia F. p53 regulates the cardiac transcriptome. Proc. Natl. Acad. Sci. U.S.A. 2017-02-28 [PMID: 28193895]
Hwang J, Purdy JG, Wu K et al. Estrogen-related receptor alpha is required for efficient human cytomegalovirus replication. Proc. Natl. Acad. Sci. U.S.A. 2014-12-30 [PMID: 25512541] (WB, Human)	WB	Human
Silvennoinen M, Rinnankoski-Tuikka R et al. High-fat feeding induces angiogenesis in skeletal muscle and activates angiogenic pathways in capillaries Angiogenesis 2012-10-23 [PMID: 23090645] (WB, Human)	WB	Human
Rinnankoski-Tuikka R, Silvennoinen M, Torvinen S et al. Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle Nutr Metab (Lond) 2012-06-09 [PMID: 22682013] (WB, Mouse)	WB	Mouse

Images	Ratings	Applications	Species	Date	Details
	3 reviewed by: Verified Customer	WB	Human	08/02/2023	View Summary Application Western Blot Sample Tested glioblastoma cell lysates Species Human Lot A1

Array NBP1-47254

• ERR alpha/NR3B1 Antibodies
• ERR alpha/NR3B1 ELISA Kits
• ERR alpha/NR3B1 Proteins