PAK2 Antibody

PAK2 (p21-activated kinase 2) is part of the family of PAK serine/threonine p21-activating protein kinases involved in cell survival, migration, and invasion. The PAK family of proteins mediates signals from extracellular stimuli to the cytoplasm and nucleus via its association with the small GTP-binding proteins Cdc42 and Rac. PAK2 has been shown to play a specific role in apoptosis and cytoskeletal dynamics. During caspase-mediated apoptosis, PAK2 is cleaved and the C-terminal myristoylated fragment mediates cell death and actin reorganization via the JNK signaling pathway.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB100-60456	Applications	Species
Qu Y, Misaghi S, Izrael-Tomasevic A et al. Phosphorylation of NLRC4 is critical for inflammasome activation. Nature 2012-10-01 [PMID: 22885697]

Array NB100-60456

• PAK2 Antibodies
• PAK2 Proteins