PADI2 Antibody (4D4)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 3 of 3.

Publications using H00011240-M01	Applications	Species
Blachere NE, Parveen S, Frank MO et al. High titer rheumatoid arthritis antibodies preferentially bind fibrinogen citrullinated by peptidyl arginine deiminase 4. Arthritis Rheumatol 2016-12-28 [PMID: 28029744]
Blachere NE, Parveen S, Fak J et al. Inflammatory but not apoptotic death of granulocytes citrullinates fibrinogen. Arthritis Res Ther 2015-01-01 [PMID: 26684871] (WB)	WB
Chumanevich AA, Causey CP, Knuckley BA et al. Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. Am J Physiol Gastrointest Liver Physiol. 2011-06-01 [PMID: 21415415] (IF/IHC, Mouse)	IF/IHC	Mouse

Array H00011240-M01

• PADI2 Antibodies
• PADI2 ELISA Kits
• PADI2 Lysate
• PADI2 Proteins