Nogo Antibody

Nogo-B is a novel myelin-associated, intermediate-length splice variant of Nogo belonging to the reticulon family. It is a multidomain neurite growth inhibitory protein containing several discrete regions with growth inhibitory functions and is a component of the CNS myelin that prevents axonal regeneration in the adult vertebrate CNS. Nogo-B along with NGBR mediated chemotaxis in HUVECs and induced tube formation in 3-dimensional cultures. It is mostly found in intact blood vessels, smooth muscle cells, and endothelial cell, with its N terminus oriented extracellularly and is a regulator of vascular homeostasis and remodeling. It plays an important role in sporadic and familial amyotrophic lateral sclerosis

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Rabbit, Sheep.

We have publications tested in 5 applications: ELISA, ICC/IF, IF/IHC, IHC-P, WB.

Showing Publications 1 - 10 of 23. Show All 23 Publications. Collapse Publications.

Publications using NB100-56681	Applications	Species
Matteo Veronese, Sebastian Kallabis, Alexander Tobias Kaczmarek, Anushka Das, Lennart Robers, Simon Schumacher, Alessia Lofrano, Susanne Brodesser, Stefan Müller, Kay Hofmann, Marcus Krüger, Elena I Rugarli ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway Life Science Alliance 2024-05-24 [PMID: 38782601]
Gong K, Zhang Z, Chen SS et al. 6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice Acta pharmacologica Sinica 2023-07-04 [PMID: 37402997]
Li J, Sun Y, Xue C et al. Nogo-B deficiency suppresses white adipogenesis by regulating ?-catenin signaling Life sciences 2023-03-15 [PMID: 36931495] (WB, Mouse)	WB	Mouse
Wang X, Yang Y, Zhao D et al. Inhibition of high-fat diet-induced obesity via reducing of ER-resident protein Nogo occurs through multiple mechanisms Journal of Biological Chemistry 2022-01-01 [PMID: 34998825] (IHC-P, Mouse)	IHC-P	Mouse
Yousefi R, Jevdokimenko K, Kluever V Et Al. Influence of Subcellular Localization and Functional State on Protein Turnover Cells 2021-08-07 [PMID: 34359917]
Yi Chen, Wenquan Hu, Qi Li, Shiwei Zhao, Dan Zhao, Shuang Zhang, Zhuo Wei, Xiaoxiao Yang, Yuanli Chen, Xiaoju Li, Chenzhong Liao, Jihong Han, Qing Robert Miao, Yajun Duan NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity The Journal of Biological Chemistry 2021-04-02 [PMID: 33812996]
Zahavi EE, Hummel JJA, Han Y et al. Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers Developmental cell 2021-02-22 [PMID: 33571451]
Batenburg V. Mapping the Neuronal Cytoskeleton with Expansion Microscopy. Methods Cell Biol 2021-01-22 [PMID: 33478685]
Petrova V, Pearson CS, Ching J et al. Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS Nat Commun 2020-11-05 [PMID: 33154382]
Tadepalle N, Robers L et al. Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis. Life Sci Alliance 2020-01-06 [PMID: 32321733] (ICC/IF, Mouse)	ICC/IF	Mouse
Zhang S, Yu M, Guo F et al. Rosiglitazone alleviates alpha-naphthylisothiocyanate-induced intrahepatic cholestasis in mice the role of circulating 15d-PGJ2 and Nogo Br. J. Pharmacol. 2019-10-28 [PMID: 31658492]
Chino, H;Hatta, T;Natsume, T;Mizushima, N; Intrinsically Disordered Protein TEX264 Mediates ER-phagy Mol. Cell 2019-04-11 [PMID: 31006538] (WB, Human)	WB	Human
Farias GG, Freal A, Tortosa E et al. Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity Neuron 2019-02-13 [PMID: 30772082] (ICC/IF, Rat)	ICC/IF	Rat
Gao P, Wang X, Jin Y et al. Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells. Breast Cancer Res. 2018-09-12 [PMID: 30208932] (IF/IHC)	IF/IHC
Kawaguchi N, Tashiro K, Taniguchi K et al. Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells Biochim. Biophys. Acta 2018-04-20 [PMID: 29684585] (IF/IHC, WB, Human)	IF/IHC, WB	Human
Jin Y, Hu W, Liu T et al. Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel. Cancer Lett. 2018-04-10 [PMID: 29373839] (Human)		Human
Rodriguez-Feo JA, Gallego-Delgado J, Puerto M et al. Reticulon-4B/Nogo-B acts as a molecular linker between microtubules and actin cytoskeleton in vascular smooth muscle cells. Biochim. Biophys. Acta. 2016-04-28 [PMID: 27132996] (ICC/IF, WB, Rat)	ICC/IF, WB	Rat
Teng RJ, Rana U, Afolayan AJ et al. Nogo-B Receptor Modulates Angiogenesis Response of Pulmonary Artery Endothelial Cells Through eNOS Coupling. Am. J. Respir. Cell Mol. Biol. 2014-02-25 [PMID: 24568601] (IHC-P, WB, Sheep) Details: IHC-P (lung), Fig 1A-D; WB [lung, pulmonary artery endothelial cells (PAEC)], Fig 1E-F. For IHC-P, the Nogo pAb was used at 1:4000. Two bands were observed in WB for Nogo in both lung and PAEC, similar to previous reports in the literature. These bands we	IHC-P, WB	Sheep
Jozsef L, Tashiro K, Kuo A et al. Reticulon 4 is necessary for ER tubulation, STIM1-Orai1 coupling and store-operated calcium entry. J. Biol. Chem. 2014-03-11 [PMID: 24558039] (WB, ICC/IF, Mouse) Details: Mouse embryo fibroblasts (MEFs) including wildytpe (WT), knockout (kO) and RTN4b stably transfected: WB (Figs 1A, 1C, 1D; 7A, 8A, 8D), IF (Figs 1B, 12A)Note: The specificity of the pAb was validated in RTN-kO versus wildtype MEFs by WB, and in RTN4b stabl	WB, ICC/IF	Mouse
Chan RT, Russell RA, Marcal H et al. BioPEGylation of Polyhydroxybutyrate Promotes Nerve Cell Health and Migration. Biomacromolecules 2014-01-13 [PMID: 24299034] (WB, Rat)	WB	Rat
Wang B, Zhao B, North P et al. Expression of NgBR is highly associated with estrogen receptor alpha and survivin in breast cancer. PLoS One 2013-01-01 [PMID: 24223763] (Rabbit)		Rabbit
Gramolini AO, Kislinger T, Alikhani-Koopaei R et al. Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses. Mol Cell Proteomics. 2008-03-01 [PMID: 18056057] (WB, Mouse) Details: WB, mouse heart tissue: 1. IMG- 5346A (Nogo A/B): Fig. C. 2. IMG-3374 (FHL1): Figs. 3C; 4A, B; 6; 8A, B.	WB	Mouse
Rodriguez-Feo JA, Hellings WE, Verhoeven BA et al. Low levels of Nogo-B in human carotid atherosclerotic plaques are associated with an atheromatous phenotype, restenosis, and stenosis severity. Arterioscler Thromb Vasc Biol. 2007-06-01 [PMID: 17413036] (ELISA, Human) Details: Nogo-A/B (IMG-5346A). ELISA: Human plasma, Fig 3.	ELISA	Human
Show All 23 Publications. Collapse Publications.

Array NB100-56681

• Nogo Antibodies
• Nogo ELISA Kits
• Nogo Lysates
• Nogo Proteins