NMDAR2A Antibody

The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IP, WB.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using NB300-105	Applications	Species
Funke JR, Hwang EK, Wunsch AM et al. Persistent neuroadaptations in the nucleus accumbens core accompany incubation of methamphetamine craving in male and female rats eNeuro 2023-02-13 [PMID: 36792361] (WB, Rat)	WB	Rat
Zhou J, Geng Y, Su T et al. NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury Cell reports 2022-03-29 [PMID: 35354047] (WB, Mouse)	WB	Mouse
Yu XJ, Xiao T, Liu XJ et al. Effects of Nrf1 in Hypothalamic Paraventricular Nucleus on Regulating the Blood Pressure During Hypertension Frontiers in neuroscience 2021-12-06 [PMID: 34938159] (WB, Rat)	WB	Rat
Ni J, Ren Y, Su T Et al. Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies Molecular psychiatry 2021-10-25 [PMID: 34697451]
Kl�ssendorf M, Song I, Schau L et al. The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5 Molecular Neurobiology 2021-11-01 [PMID: 34383253] (WB, ICC/IF)	WB, ICC/IF
Jiang A, Su P, Li S et al. Disrupting the alpha 7nAChR-NR2A protein complex exerts antidepressant-like effects Molecular brain 2021-07-05 [PMID: 34225758] (WB)	WB
Li Y, Lu YX, Chi HL et al. Chronic Blockade of NMDAR Subunit 2A in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension through Suppression of MEK/ERK/CREB Pathway American journal of hypertension 2021-04-15 [PMID: 33856436]
Hassani Nia, F, Woike, D Et al. Targeting of delta-catenin to postsynaptic sites through interaction with the Shank3 N-terminus. Mol Autism 2020-10-28 [PMID: 33115499] (ICC/IF, Human)	ICC/IF	Human
Zhang N, Zhang Z, He R et al. GLAST-CreER(T2) mediated deletion of GDNF increases brain damage and exacerbates long-term stroke outcomes after focal ischemic stroke in mouse model Glia 2020-06-04 [PMID: 32497340]
Koster K, Francesconi W, Berton F et al. NMDA Receptor Dysregulation by Defective Depalmitoylation in the Infantile Neuronal Ceroid Lipofuscinosis Mouse Model bioRxiv 2018-08-13 [PMID: 30946007] (WB, Mouse)	WB	Mouse
Koster, KP;Francesconi, W;Berton, F;Alahmadi, S;Srinivas, R;Yoshii, A; Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model Elife 2019-04-04 [PMID: 30946007] (WB, Mouse)	WB	Mouse
Wang X, Zhao L, Zhang J et al. Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina. J Neurosci 2016-03-02 [PMID: 26937019] (IF/IHC)	IF/IHC
Lo SC, Wang Y, Weber M et al. Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control J. Neurosci. 2015-02-04 [PMID: 25653368] (WB, Mouse) Details: NMDAR2A (GluN2A/NR2A) antibody used for WB analysis of the lysates from hippocampus tissues which were collected from experienced mice (11 months of age; tissues collected 1 month after the last behavior testing ) from WT and Casp3?/? mice genotypes previously subjected to repeated challenges with new behavioral testing (Figure 7B).	WB	Mouse
Hanson JE, Pare J, Deng L et al. Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease. Neurobiol. Dis. 2014-12-04 [PMID: 25484285] (WB, Mouse) Details: NMDAR2A antibody used for WB at 1:1000 dilution on brain lysates from male mice homozygous for the PS2APP transgenes (mouse model of Alzheimer's disease) and their wt littermate controls.	WB	Mouse
Das SR, Magnusson KR. Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging. Behav Brain Res;222(1):122-133. 2011-09-12 [PMID: 21443909] (WB, Mouse)	WB	Mouse
Karolewicz B, Szebeni K, Gilmore T et al. Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression. Int J Neuropsychopharmacol 2009-03-01 [PMID: 18570704] (WB, Human)	WB	Human
Ning, K et al. Dual Neuroprotective Signaling Mediated by Downregulating Two Distinct Phosphatase Activities of PTEN. The Journal of Neuroscience; 24: 4052-4060. 2004-01-01 [PMID: 15102920] (WB, IP, Rat)	WB, IP	Rat
Show All 17 Publications. Collapse Publications.

Array NB300-105

• NMDAR2A Antibodies
• NMDAR2A ELISA Kit