Human Neutrophil Elastase/ELA2 ELISA Kit (Colorimetric)

The human organism reacts with an inflammatory response to attacks of invading pathogens (microorganisms and viruses) or damaged tissue (after accidents or surgery). Polymorphonuclear (PMN) granulocytes play an important role as primary defence cells in this inflammatory reaction. Different bloodstream mediators (cytokines, leukotrienes, complement factors, bacterial endotoxins, clotting and fibrinolysis factors) attract and stimulate these cells to phagocytize and destroy not naturally occurring agents. PMN granulocytes use proteinases to digest these agents and tissue debris. One of these proteinases is PMN elastase which is localised in the azurophilic granules of the polymorphonuclear granulocytes. During phagocytosis of foreign substances these enzymes are also partially excreted into the extracellular surrounding, where the activity of PMN elastase is regulated by inhibitors (esp. the alpha 1-proteinase inhibitor, alpha 1- PI). An overwhelming release of PMN elastase, however, can exceed the inhibitory potential of the alpha 1-proteinase inhibitor. Thus, enzymatically active PMN elastase, together with simultaneously produced oxidants (O2-radicals, H2O, OH-radicals), can cause local tissue injury. Due to the bloodstream and lymphatic system, however, alpha 1-PI is delivered subsequently and eventually able to form a complex with all excreted elastase. Therefore, the concentration of the PMN elastase/alpha 1- PI complex correlates with the released PMN elastase and can be used as a measure for the activity of granulocytes during an inflammatory response. Primarily, determinations of PMN elastase find its application in observation of the course of trauma, shock and sepsis. Further indications are the areas of hemodialysis, infections by obstetrics, joint diseases, effusions of sport injuries, intestinal affection, pancreatitis, cystic fibrosis and male adnex affections.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA.

Showing Publications 1 - 2 of 2.

Publications using NBP1-91266	Applications	Species
Choi SR, Hong SS, Kim J, Lee KY. Neutrophil elastase in cervical fluid in women with short cervical length Taiwan J Obstet Gynecol. [PMID: 29880174] (ELISA, Human)	ELISA	Human
Xiao Y, Deng Y, Yuan F et al. An ATF4/ATG5 Signaling in Hypothalamic POMC Neurons Regulates Fat Mass via Affecting Energy Expenditure. Diabetes. 2017-02-17 [PMID: 28213613] (ELISA, Human)	ELISA	Human

Array NBP1-91266

• Neutrophil Elastase/ELA2 Antibodies
• Neutrophil Elastase/ELA2 ELISA Kits
• Neutrophil Elastase/ELA2 Lysate
• Neutrophil Elastase/ELA2 Protein
• Neutrophil Elastase/ELA2 Proteins and Enzymes
• Neutrophil Elastase/ELA2 ELISAs