Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC, CyTOF-ready, Flow, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Mu
Applications: Enzyme Activity
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: AC
Description
The ELANE gene (commonly known as neutrophil elastase) encodes a 267 amino acid long, 28 kDA neutrophil elastase protein that functions in regulation of natural killer cells, monocytes, and graulocytes. ELANE is involved in activation of proMMP8, cell adhesion cell-matrix glycoconjugates, selected targets of C/EBPbeta, degradation of the extracellular matrix and collagen, and amb2 integrin signaling. It interacts with various genes GZMB, LRP1, SERPINF2, SERPING1, and SERPINA1. Elane has been linked to cystic fibrosis, asthma, pneumonia, alzheimer's disease, neutropenia, cutis laxia, leg ulcers, wegener's granulomatosis, bronchitis, adult respiratory distress syndrome, and vascular diseases.
Bioinformatics
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
1991 |
| Alternate Names |
- Bone marrow serine protease
- EC 3.4.21
- EC 3.4.21.37
- ELA2granulocyte-derived elastase
- elastase 2, neutrophil
- elastase, neutrophil expressed
- Elastase-2
- GE
- HLEelastase-2
- HNE
- Human leukocyte elastase
- leukocyte elastase
- medullasin
- Medullasin
- NE
- neutrophil elastase
- PMN elastase
- PMN-E
- polymorphonuclear elastase
- SCN1
|
Research Areas for Neutrophil Elastase/ELA2
Find related products by research area and learn more about each of the different research areas below.
CancerNeuroscience
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![Immunocytochemistry Neutrophil Elastase/ELA2 Antibody (950317) [Unconjugated]](http://images.novusbio.com/fullsize2/Neutrophil_Elastase_MAB91671_Immunocytochemistry__Immunofluorescence_20416.jpg)
![Immunohistochemistry Neutrophil Elastase/ELA2 Antibody (950317) [Unconjugated]](http://images.novusbio.com/fullsize2/Neutrophil_Elastase_MAB91671_Immunohistochemistry_20415.jpg)
![Intracellular Staining by Flow Cytometry Neutrophil Elastase/ELA2 Antibody (950317) [Unconjugated]](http://images.novusbio.com/fullsize2/Neutrophil_Elastase_MAB91671_Flow_Cytometry_20518.jpg)
![N/A Neutrophil Elastase/ELA2 [Biotin]](http://images.novusbio.com/fullsize2/DATA_Neutrophil_Elastase_DY916705_ELISA_2558.jpg)
![N/A Neutrophil Elastase/ELA2 [Biotin]](http://images.novusbio.com/fullsize2/DATA_Neutrophil_Elastase_DY451705_ELISA_2461.jpg)
![N/A Neutrophil Elastase/ELA2 [HRP]](http://images.novusbio.com/fullsize2/Neutrophil_Elastase_MELA20_ELISA_2680.jpg)
![N/A Neutrophil Elastase/ELA2 [HRP]](http://images.novusbio.com/fullsize2/Neutrophil_Elastase_MELA20_ELISA_2681.jpg)
