Human Neutrophil Elastase/ELA2 DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neutrophil Elastase (ELA2), also known as polymorphonuclear leukocyte elastase, is a serine protease belonging to the chymotrypsin family. Located primarily in the azurophil granules of polymorphonuclear leukocytes, ELA2 function results in the degradation of many extracellular matrix macromolecules. Alpha-1 Antitrypsin (Serpin A1) and secretory leukocyte protease inhibitor (SLPI) have been shown to inhibit ELA2 activity. ELA2 may be involved in lung emphysema, cystic fibrosis, the adult respiratory distress syndrome (ARDS), rheumatoid arthritis, tumor invasion and infectious diseases.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 23. Show All 23 Publications. Collapse Publications.

Publications using DY9167-05	Applications	Species
Da Silva Cunha, AL;Blanter, M;Renders, J;Gouwy, M;Lorent, N;Boon, M;Struyf, S;Carlon, MS; Inhibiting CFTR through inh-172 in primary neutrophils reveals CFTR-specific functional defects Scientific reports 2024-12-28 [PMID: 39732786] (Human)		Human
Hanford, HE;Price, CTD;Uriarte, S;Abu Kwaik, Y; Inhibition and evasion of neutrophil microbicidal responses by Legionella longbeachae mBio 2024-12-16 [PMID: 39679679] (Human)		Human
Mirandola, A;Kudriavtsev, A;Cofre Muñoz, CI;Navarro, RC;Macagno, M;Daoud, S;Sanchez, C;Pastor, B;Pisareva, E;Marin, MS;Ruiz, JG;Piris, A;Rodriguez, AG;Gonzalez, NS;Vivancos, A;Quarà, V;Mellano, A;Borghi, F;Corti, G;Marchiò, C;Sapino, A;Bartolini, A;Crisafulli, G;Bardelli, A;Di Maio, M;Lossaint, G;Frayssinoux, F;Crapez, E;Ychou, M;Soler, RS;Fenocchio, E;Fernandez Calotti, PX;Mazard, T;Vivas, CS;Elez, E;Di Nicolantonio, F;Thierry, AR; Post-surgery sequelae unrelated to disease progression and chemotherapy revealed in follow-up of patients with stage III colon cancer EBioMedicine 2024-09-19 [PMID: 39303668] (Human)		Human
Nicola, T;Wenger, N;Xu, X;Evans, M;Qiao, L;Rezonzew, G;Yang, Y;Jilling, T;Margaroli, C;Genschmer, K;Willis, K;Ambalavanan, N;Blalock, JE;Gaggar, A;Lal, CV; A lactobacilli-based inhaled live biotherapeutic product attenuates pulmonary neutrophilic inflammation Nature communications 2024-08-19 [PMID: 39160214] (Human)		Human
Das, S;Kaminski, TW;Schlegel, BT;Bain, W;Hu, S;Patel, A;Kale, SL;Chen, K;Lee, JS;Mallampalli, RK;Kagan, VE;Rajasundaram, D;McVerry, BJ;Sundd, P;Kitsios, GD;Ray, A;Ray, P; Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure Nature communications 2024-06-03 [PMID: 38830855] (Human)		Human
Ramakrishnan, G;Young, MK;Nayak, U;Rigo, I;Marrs, AS;Gilchrist, CA;Behm, BW;Madden, GR;Petri, WA; Systemic neutrophil degranulation and emergency granulopoiesis in patients with Clostridioides difficile infection Anaerobe 2024-03-19 [PMID: 38514010] (Human)		Human
Pastorek, M;Kone?ná, B;Janko, J;Janovi?ová, ?;Podracká, ?;Záhumenský, J;Šte?ová, E;Dúbrava, M;Hodosy, J;Vlková, B;Celec, P; Mitochondria-induced formation of neutrophil extracellular traps is enhanced in the elderly via Toll-like receptor 9 Journal of leukocyte biology 2023-08-30 [PMID: 37648664] (Human)		Human
Bakalovi?, G;Bokonji?, D;Mihajlovi?, D;?oli?, M;Mališ, V;Drakul, M;Tomi?, S;Joji?, I;Rako?evi?, S;Popovi?, D;Kozi?, L;Vasiljevi?, M;Beki?, M;Maši?, S;Ljuboja, O; Dysfunctions of Neutrophils in the Peripheral Blood of Children with Cystic Fibrosis Biomedicines 2023-06-15 [PMID: 37371820] (Human)		Human
Chen, L;Liu, Y;Wang, Z;Zhang, L;Xu, Y;Li, Y;Zhang, L;Wang, G;Yang, S;Xue, G; Mesenchymal stem cell-derived extracellular vesicles protect against abdominal aortic aneurysm formation by inhibiting NET-induced ferroptosis Experimental & molecular medicine 2023-05-01 [PMID: 37121969] (Human)		Human
M Blanter, M Cockx, L Wittebols, S Abouelasra, M De Bondt, N Berghmans, N Pörtner, L Vanbrabant, N Lorent, M Gouwy, M Boon, S Struyf Sputum from patients with primary ciliary dyskinesia contains high numbers of dysfunctional neutrophils and inhibits efferocytosis Respiratory Research, 2022-12-17;23(1):359. 2022-12-17 [PMID: 36528664] (Human)		Human
L Morimont, M Dechamps, C David, C Bouvy, C Gillot, H Haguet, J Favresse, L Ronvaux, J Candiracci, M Herzog, PF Laterre, J De Poorter, S Horman, C Beauloye, J Douxfils NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients: An Observational Study Biomolecules, 2022-07-27;12(8):. 2022-07-27 [PMID: 36008932] (Human)		Human
SA Maskarinec, M McKelvy, K Boyle, H Hotchkiss, ME Duarte, B Addison, N Amato, S Khandelwal, GM Arepally, GM Lee Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles Journal of leukocyte biology, 2022-08-02;0(0):. 2022-08-02 [PMID: 35916035] (Human)		Human
MA Wesdorp, A Schwab, EI Bektas, R Narcisi, D Eglin, MJ Stoddart, GJVM Van Osch, M D'Este A culture model to analyze the acute biomaterial-dependent reaction of human primary neutrophils in vitro Oncogene, 2022-07-02;20(0):627-637. 2022-07-02 [PMID: 35846845] (Human)		Human
VB Pacheco, G Nery, LL Fernandes, TV Santana, M Jimenez, L Borges, E Hatanaka, P Braga, FR Monteiro, JB Amaral, LS Alves, ALL Bachi, SG da Silva, A Birbrair, D Heller Salivary Proteome, Inflammatory, and NETosis Biomarkers in Older Adult Practitioners and Nonpractitioners of Physical Exercise Oxidative Medicine and Cellular Longevity, 2022-04-23;2022(0):3725056. 2022-04-23 [PMID: 35502212] (Human)		Human
KC Ngamsri, RA Putri, C Jans, K Schindler, A Fuhr, Y Zhang, J Gamper-Tsi, S Ehnert, FM Konrad CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling International Journal of Molecular Sciences, 2021-12-17;22(24):. 2021-12-17 [PMID: 34948374] (Human)		Human
S Cambier, M Metzemaeke, AC Carvalho, A Nooyens, C Jacobs, L Vanderbeke, B Malengier-, M Gouwy, E Heylen, P Meersseman, G Hermans, E Wauters, A Wilmer, C Consortium, D Schols, P Matthys, G Opdenakker, RE Marques, J Wauters, J Vandooren, P Proost Atypical response to bacterial co-infection and persistent neutrophilic broncho-alveolar inflammation distinguish critical COVID-19 from influenza JCI Insight, 2022-01-11;0(0):. 2022-01-11 [PMID: 34793331] (Human)		Human
J Huckriede, SB Anderberg, A Morales, F de Vries, M Hultström, A Bergqvist, JT Ortiz-Pére, JW Sels, K Wichapong, M Lipcsey, M van de Pol, A Larsson, T Luther, C Reutelings, PG de Frutos, R Frithiof, GAF Nicolaes Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients Scientific Reports, 2021-08-03;11(1):15701. 2021-08-03 [PMID: 34344929] (Human)		Human
C Thomas, H Nothaft, R Yadav, C Fodor, A Alemka, O Oni, M Bell, B Rada, CM Szymanski Characterization of ecotin homologs from Campylobacter rectus and Campylobacter showae PLoS ONE, 2020-12-30;15(12):e0244031. 2020-12-30 [PMID: 33378351] (Human)		Human
SJCFM Moorlag, YA Rodriguez-, J Gillard, S Fanucchi, K Theunissen, B Novakovic, CM de Bont, Y Negishi, ET Fok, L Kalafati, P Verginis, VP Mourits, VACM Koeken, LCJ de Bree, GJM Pruijn, C Fenwick, R van Crevel, LAB Joosten, I Joosten, H Koenen, MM Mhlanga, DA Diavatopou, T Chavakis, MG Netea BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils Cell Rep, 2020-11-17;33(7):108387. 2020-11-17 [PMID: 33207187] (Human)		Human
J Cassuto, A Folestad, J Göthlin, H Malchau, J Kärrholm Concerted actions by MMPs, ADAMTS and serine proteases during remodeling of the cartilage callus into bone during osseointegration of hip implants Bone Rep, 2020-09-11;13(0):100715. 2020-09-11 [PMID: 32995386] (Human)		Human
S Castellani, S D'Oria, A Diana, AM Polizzi, S Di Gioia, MA Mariggiò, L Guerra, M Favia, A Vinella, G Leonetti, D De Venuto, C Gallo, P Montemurro, M Conese G-CSF and GM-CSF Modify Neutrophil Functions at Concentrations found in Cystic Fibrosis Sci Rep, 2019-09-10;9(1):12937. 2019-09-10 [PMID: 31506515] (Human)		Human
W Hao, M Li, Y Zhang, C Zhang, Y Xue Expressions of MMP-12, TIMP-4, and Neutrophil Elastase in PBMCs and Exhaled Breath Condensate in Patients with COPD and Their Relationships with Disease Severity and Acute Exacerbations J Immunol Res, 2019-04-17;2019(0):7142438. 2019-04-17 [PMID: 31143784] (Human)		Human
HM Alyami, LS Finoti, HS Teixeira, A Aljefri, DF Kinane, MR Benakanake Role of NOD1/NOD2 receptors in Fusobacterium nucleatum mediated NETosis Microb. Pathog., 2019-03-30;0(0):. 2019-03-30 [PMID: 30940608] (Human)		Human
Show All 23 Publications. Collapse Publications.

Array DY9167-05

• Neutrophil Elastase/ELA2 Antibodies
• Neutrophil Elastase/ELA2 ELISA Kits
• Neutrophil Elastase/ELA2 Lysate
• Neutrophil Elastase/ELA2 Protein
• Neutrophil Elastase/ELA2 Proteins and Enzymes
• Neutrophil Elastase/ELA2 ELISAs