Neurturin Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neurturin (NTN) is a member of the GDNF family of ligands which also includes glial cell-derived neurotrophic factor (GDNF), persephin, and artemin. GDNF family proteins are distant members of the TGF-beta superfamily and contain a conserved seven cysteine motif found in the entire family. Human NTN encodes a 197 amino acid (aa) preproprotein with a 19 aa residue putative signal peptide and a 76 aa pro region. Proteolytic cleavage of the pro-protein occurs at an RXXR consensus sequence. The native protein is a disulfide-linked homodimer with a calculated monomeric mass of about 12.5 kDa. The amino acid sequence of human NTN shares 91% identity to mouse NTN. NTN also shares about 42% similarity with GDNF. The bioactivities of all GDNF family ligands are mediated through a receptor complex composed of a high affinity ligand binding component (GFR alpha 1 - GFR alpha 4) and a common signaling component, cRET (receptor tyrosine kinase). NTN prefers to bind GFR alpha 2 but can also bind GFR alpha 1. NTN can promote the survival of a variety of neurons including sympathetic, sensory, and central nervous system neurons. The wide expression of NTN in both neuronal and non-neuronal tissues suggests that NTN may regulate the development and maintenance of the central and peripheral nervous systems and other systems.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array BAF477

• Neurturin Antibodies
• Neurturin ELISA Kits
• Neurturin Lysate
• Neurturin Proteins
• Neurturin Proteins and Enzymes