EDNRB/Endothelin R Type B Antibody - BSA Free

The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel. ESTs have been isolated from amnion, B-cell/lung/testis, breast, brain, colon, ear, embryo, eye, heart, kidney, liver, liver/spleen, lung, lymph node, placenta, prostate, and skin libraries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 3 of 3.

Publications using NLS54	Applications	Species
Milara J, Roger I, Montero P et al. Targeting IL-11 system as a treatment of pulmonary arterial hypertension Pharmacological research 2023-11-01 [PMID: 37949331]
Rizvi AH, Camara PG, Kandror EK et al. Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development. Nat. Biotechnol. 2017-06-01 [PMID: 28459448] (ICC/IF, Mouse)	ICC/IF	Mouse
Comellas AP, Briva A, Dada LA et al. Endothelin-1 Impairs Alveolar Epithelial Function via Endothelial ETB Receptor. Am J Respir Crit Care Med;179(2):113-122. 2009-01-01 [PMID: 18948426]

Array NLS54

• EDNRB/Endothelin R Type B Antibodies
• EDNRB/Endothelin R Type B ELISA Kit
• EDNRB/Endothelin R Type B Lysates
• EDNRB/Endothelin R Type B Protein