NEDD9/CASL/HEF1 Antibody

rs760678 SNP of the NEDD9 gene is a weak genetic determinant of Alzheimer's disease and Parkinson's disease. Cas-L is one of the targets of inflammatory cytokines and is also modulated by cell adhesion process in neutrophils. NEDD9 is directly regulated by atRA through a complex retinoic acid response element (RARE) located in the NEDD9 proximal promoter and consisting of four conserved half-sites separated by 1, 5, and 1 intervening base pairs. HEF1/NEDD9/Cas-L expression and function in signaling relevant to cell attachment, migration, invasion, cell cycle, apoptosis, and oncogenic signal transduction. Evidence is presented that variation in NEDD9 is associated wih susceptibility to late-onset Alzheimer and Parkinson diseases. Observational study of gene-disease association. (HuGE Navigator). Changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to be a potent prometastatic stimulus in melanoma and other cancers. NEDD9 is regulated in neuroblastoma cells by all-trans retinoic acid. Cas-L plays an important role in the pathophysiology of rheumatoid arthritis. Reults demonstrate the function of atrophin-1-interacting protein 4 as an ubiquitin E3 ligase for human enhancer of filamentation 1. The HEF1 protein overexpression of HEF1 causes an increase in centrosome numbers and multipolar spindles, resembling defects induced by manipulation of the mitotic regulatory kinase Aurora-A (AurA). NEDD9 (Cas-L) binds human T-lymphotropic virus type I (HTLV-I) Tax and specifically regulates Tax-NF-kappaB pathway. These results suggest that the adhesion-dependent actin organization regulates proteasomal turnover of HEF1 through the activity of PP2A. HEF1-promoted processes actively extend from the cell body and resemble neurites both in the manner of process extension and in the distribution of adhesion-associated molecules. HEF1 associates with the RhoA-GTP exchange factor ECT2, an orthologue of the Drosophila cytokinetic regulator Pebble, providing a direct means for HEF1 control of RhoA. HEF1 expression is regulated by TGF-beta1 and HEF1 phosphorylation is dependent on cell adhesion and Src kinase activity

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NB100-68151

• NEDD9/CASL/HEF1 Antibodies
• NEDD9/CASL/HEF1 Proteins