Argininosuccinate Lyase Antibody

Argininosuccinate Lyase encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Canine.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-87462	Applications	Species
Dai W, Shen J, Yan J et al. Glutamine synthetase limits b-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1 The Journal of clinical investigation 2022-10-18 [PMID: 36256480] (WB, Mouse) Details: Dilution used for WB 1:1000	WB	Mouse
van Straten G, van Steenbeek FG, Grinwis GC et al. Aberrant Expression and Distribution of Enzymes of the Urea Cycle and Other Ammonia Metabolizing Pathways in Dogs with Congenital Portosystemic Shunts. PLoS One 2014-01-01 [PMID: 24945279] (IF/IHC, Canine)	IF/IHC	Canine

Array NBP1-87462

• Argininosuccinate Lyase Antibodies
• Argininosuccinate Lyase Lysates
• Argininosuccinate Lyase Proteins